Plant Transcription factor database - Universität Potsdam
version: 3.0

Arabidopsis lyrata AP2-EREBP Family


Riechmann & Meyerowitz. 1998: AP2 (APETALA2) and EREBPs (ethylene-responsive element binding proteins) are the prototypic members of a family of transcription factors unique to plants, whose distinguishing characteristic is that they contain the so-called AP2 DNA-binding domain. AP2/ REBP genes form a large multigene family, and they play a variety of roles throughout the plant life cycle: from being key regulators of several developmental processes, like floral organ identity determination or control of leaf epidermal cell identity, to forming part of the mechanisms used by plants to respond to various types of biotic and environmental stress.

Shigyo et al. 2006: AP2/EREBP genes are divided into two subfamilies: AP2 genes with two AP2 domains and EREBP genes with a single AP2/ERF (Ethylene Responsive Element Binding Factor) domain. Expressions of AP2-like genes, including AP2, in Arabidopsis thaliana are regulated by the microRNA miR172. We found that the target site of miR172 is significantly conserved in gymnosperm AP2 homologs, suggesting that regulatory mechanisms of gene expression using microRNA have been conserved over the three hundred million years since the divergence of gymnosperm and flowering plant lineages.

Members of this family
  SHOULD possess AP2 domain

Domain alignments

Benchmark against A. thaliana

The Sensitivity and Positive Predictive Value (PPV) were assessed for this family. The data reported by Feng et al. 2005 for A. thaliana were taken as gold standard.

The gold standard reported 147 members for this family, 146 of which are present in ArabTFDB, giving a PPV of 1.00. One additional member not present in ArabTFDB might be a false negative, giving a Sensitivity of 0.99.

This family is also present in:


There are 149 gene models in this family

Gene modelDescriptionDomains
312283 fgenesh1_pm.C_scaffold_1001063 AP2
315617 fgenesh1_pm.C_scaffold_2000650 AP2
316221 fgenesh1_pm.C_scaffold_2001254 AP2
316902 fgenesh1_pm.C_scaffold_2001935 AP2
321616 fgenesh1_pm.C_scaffold_4001673 AP2
326806 fgenesh1_pm.C_scaffold_6002026 AP2
332869 fgenesh1_pm.C_scaffold_8002212 AP2
332870 fgenesh1_pm.C_scaffold_8002213 AP2
358841 fgenesh1_pg.C_scaffold_8002628 AP2
470149 fgenesh2_kg.1__103__AT1G01250.1 AP2
470633 fgenesh2_kg.1__587__AT1G06160.1 AP2
471409 fgenesh2_kg.1__1363__AT1G12610.1 AP2
471442 fgenesh2_kg.1__1396__AT1G12890.1 AP2
471733 fgenesh2_kg.1__1687__AT1G15360.1 AP2
471806 fgenesh2_kg.1__1760__AT1G16060.1 AP2
472144 fgenesh2_kg.1__2098__AT1G19210.1 AP2
472427 fgenesh2_kg.1__2381__AT1G21910.1 AP2
472454 fgenesh2_kg.1__2408__AT1G22190.1 AP2
472549 fgenesh2_kg.1__2503__AT1G22985.1 AP2
472824 fgenesh2_kg.1__2778__AT1G25470.1 AP2
473024 fgenesh2_kg.1__2978__AT1G28160.1 AP2
473050 fgenesh2_kg.1__3004__AT1G28360.1 AP2
473051 fgenesh2_kg.1__3005__AT1G28370.1 AP2
473706 fgenesh2_kg.1__3660__AT1G36060.1 AP2
473823 fgenesh2_kg.1__3777__AT1G44830.1 AP2
474053 fgenesh2_kg.1__4007__AT1G49120.1 AP2
474196 fgenesh2_kg.1__4150__AT1G50640.1 AP2
474200 fgenesh2_kg.1__4154__AT1G50680.1 AP2 B3
474227 fgenesh2_kg.1__4181__AT1G51120.1 AP2 B3
474440 fgenesh2_kg.1__4394__AT1G53170.1 AP2
474912 fgenesh2_kg.2__42__AT1G64380.1 AP2
475045 fgenesh2_kg.2__175__AT1G63030.1 AP2
475977 fgenesh2_kg.2__1107__AT1G68550.2 AP2
476011 fgenesh2_kg.2__1141__AT1G68840.1 AP2 B3
476245 fgenesh2_kg.2__1375__AT1G71130.1 AP2
476276 fgenesh2_kg.2__1406__AT1G71450.1 AP2
476281 fgenesh2_kg.2__1411__AT1G71520.1 AP2
476631 fgenesh2_kg.2__1761__AT1G74930.1 AP2
476698 fgenesh2_kg.2__1828__AT1G75490.1 AP2
476884 fgenesh2_kg.2__2014__AT1G77200.1 AP2
476928 fgenesh2_kg.2__2058__AT1G77640.1 AP2
476975 fgenesh2_kg.2__2105__AT1G78080.1 AP2
477146 fgenesh2_kg.2__2276__AT1G79700.2 AP2
478447 fgenesh2_kg.3__1148__AT3G11020.1 AP2
479554 fgenesh2_kg.3__2255__AT3G20310.1 AP2
479836 fgenesh2_kg.3__2537__AT3G23220.1 AP2
479837 fgenesh2_kg.3__2538__AT3G23230.1 AP2
480862 fgenesh2_kg.3__3563__AT2G20350.1 AP2
481204 fgenesh2_kg.4__264__AT2G23340.1 AP2
481434 fgenesh2_kg.4__494__AT2G25820.1 AP2
481765 fgenesh2_kg.4__825__AT2G28550.1 AP2
482050 fgenesh2_kg.4__1110__AT2G31230.1 AP2
482320 fgenesh2_kg.4__1380__AT2G33710.1 AP2
482537 fgenesh2_kg.4__1597__AT2G35700.1 AP2
482845 fgenesh2_kg.4__1905__AT2G38340.1 AP2
483251 fgenesh2_kg.4__2311__AT2G41710.2 AP2
483623 fgenesh2_kg.4__2683__AT2G44940.1 AP2
483781 fgenesh2_kg.4__2841__AT2G46310.1 AP2
483933 fgenesh2_kg.4__2993__AT2G47520.1 AP2
484335 fgenesh2_kg.5__327__AT3G25730.1 AP2 B3
485380 fgenesh2_kg.5__1372__AT3G50260.1 AP2
485830 fgenesh2_kg.5__1822__AT3G54320.1 AP2
485918 fgenesh2_kg.5__1910__AT3G54990.1 AP2
486209 fgenesh2_kg.5__2201__AT3G57600.1 AP2
486521 fgenesh2_kg.5__2513__AT3G60490.1 AP2
486651 fgenesh2_kg.5__2643__AT3G61630.1 AP2
487335 fgenesh2_kg.6__469__AT5G05410.1 AP2
487556 fgenesh2_kg.6__690__AT5G07310.1 AP2
487996 fgenesh2_kg.6__1130__AT5G11590.1 AP2
488151 fgenesh2_kg.6__1285__AT5G13330.1 AP2
488739 fgenesh2_kg.6__1873__AT5G18560.1 AP2
489371 fgenesh2_kg.6__2505__AT5G25190.1 AP2
489689 fgenesh2_kg.6__2823__AT4G06746.1 AP2
489952 fgenesh2_kg.6__3086__AT4G11140.1 AP2
490762 fgenesh2_kg.7__195__AT4G39780.1 AP2
490899 fgenesh2_kg.7__332__AT4G36920.1 AP2
491962 fgenesh2_kg.7__1395__AT4G28140.1 AP2
492279 fgenesh2_kg.7__1712__AT4G25470.1 AP2
492491 fgenesh2_kg.7__1924__AT4G23750.1 AP2
493126 fgenesh2_kg.7__2559__AT4G17500.1 AP2
493127 fgenesh2_kg.7__2560__AT4G17490.1 AP2
493200 fgenesh2_kg.7__2633__AT4G16750.1 AP2
493551 fgenesh2_kg.7__2984__AT4G13620.1 AP2
494253 fgenesh2_kg.8__69__AT5G47230.1 AP2
494254 fgenesh2_kg.8__70__AT5G47220.1 AP2
494572 fgenesh2_kg.8__388__AT5G44210.1 AP2
495065 fgenesh2_kg.8__881__AT5G50080.1 AP2
495189 fgenesh2_kg.8__1005__AT5G51190.1 AP2
495839 fgenesh2_kg.8__1655__AT5G57390.1 AP2
496151 fgenesh2_kg.8__1967__AT5G60120.1 AP2
496326 fgenesh2_kg.8__2142__AT5G61590.1 AP2
496327 fgenesh2_kg.8__2143__AT5G61600.1 AP2
496690 fgenesh2_kg.8__2506__AT5G64750.1 AP2
497236 fgenesh2_kg.71__6__AT5G60120.1 AP2
497440 fgenesh2_kg.471__1__AT3G23230.1 AP2
856016 Al_scaffold_0240_1 AP2
861519 Al_scaffold_0006_1028 AP2
862141 Al_scaffold_0006_1650 AP2
862319 Al_scaffold_0006_1828 AP2
870458 Al_scaffold_0004_2621 AP2
870655 Al_scaffold_0004_2818 AP2
874157 Al_scaffold_0003_2798 AP2
875616 Al_scaffold_0002_210 AP2
886837 Al_scaffold_0008_3101 AP2
887537 scaffold_100331.1 AP2
887599 scaffold_100393.1 AP2
888596 scaffold_101390.1 AP2
888650 scaffold_101444.1 AP2
888685 scaffold_101479.1 AP2 B3
889793 scaffold_102587.1 AP2
890147 scaffold_102941.1 AP2 B3
890210 scaffold_103004.1 AP2
890960 scaffold_103754.1 AP2
891481 scaffold_104275.1 AP2
892081 scaffold_104875.1 AP2
892441 scaffold_105235.1 AP2
897690 scaffold_301660.1 AP2
897795 scaffold_301765.1 AP2
897935 scaffold_301905.1 AP2
897996 scaffold_301966.1 AP2
898520 scaffold_302490.1 AP2
898836 scaffold_302806.1 AP2
900468 scaffold_304438.1 AP2
900671 scaffold_400172.1 AP2
902763 scaffold_402264.1 AP2
903325 scaffold_402826.1 AP2
903921 scaffold_403422.1 AP2
904766 scaffold_500470.1 AP2
908707 scaffold_600764.1 AP2
909007 scaffold_601064.1 AP2
909345 scaffold_601402.1 AP2
909855 scaffold_601912.1 AP2
910017 scaffold_602074.1 AP2
910177 scaffold_602234.1 AP2
912253 scaffold_604310.1 AP2
912555 scaffold_700297.1 AP2
912628 scaffold_700370.1 AP2
912950 scaffold_700692.1 AP2
913157 scaffold_700899.1 AP2
913363 scaffold_701105.1 AP2
913731 scaffold_701473.1 AP2
914837 scaffold_702579.1 AP2
917307 scaffold_800707.1 AP2
918237 scaffold_801637.1 AP2
918241 scaffold_801641.1 AP2
918406 scaffold_801806.1 AP2
919438 scaffold_802838.1 AP2
919839 scaffold_803239.1 AP2
919990 scaffold_803390.1 AP2

General references

Gutterson, N; Reuber, TL. 2004. Regulation of disease resistance pathways by AP2/ERF transcription factors. Curr. Opin. Plant Biol. 7(4):465-71 PUBMEDID:15231271
Liu, Y; Zhao, TJ; Liu, JM; Liu, WQ; Liu, Q; Yan, YB; Zhou, HM. 2006. The conserved Ala37 in the ERF/AP2 domain is essential for binding with the DRE element and the GCC box. FEBS Lett. 580(5):1303-8 PUBMEDID:16457823
Magnani, E; Sjölander, K; Hake, S. 2004. From endonucleases to transcription factors: evolution of the AP2 DNA binding domain in plants. Plant Cell 16(9):2265-77 PUBMEDID:15319480
Ohme-Takagi, M; Shinshi, H. 1995. Ethylene-inducible DNA binding proteins that interact with an ethylene-responsive element. Plant Cell 7(2):173-82 PUBMEDID:7756828
Riechmann, JL; Meyerowitz, EM. 1998. The AP2/EREBP family of plant transcription factors. Biol. Chem. 379(6):633-46 PUBMEDID:9687012
Shigyo, M; Hasebe, M; Ito, M. 2006. Molecular evolution of the AP2 subfamily. Gene 366(2):256-65 PUBMEDID:16388920
Shigyo, M; Ito, M. 2004. Analysis of gymnosperm two-AP2-domain-containing genes. Dev. Genes Evol. 214(3):105-14 PUBMEDID:14986134
Weigel, D. 1995. The APETALA2 domain is related to a novel type of DNA binding domain. Plant Cell 7(4):388-9 PUBMEDID:7773013