Plant Transcription factor database - Universität Potsdam
version: 3.0

Arabidopsis thaliana AP2-EREBP Family

Description

Riechmann & Meyerowitz. 1998: AP2 (APETALA2) and EREBPs (ethylene-responsive element binding proteins) are the prototypic members of a family of transcription factors unique to plants, whose distinguishing characteristic is that they contain the so-called AP2 DNA-binding domain. AP2/ REBP genes form a large multigene family, and they play a variety of roles throughout the plant life cycle: from being key regulators of several developmental processes, like floral organ identity determination or control of leaf epidermal cell identity, to forming part of the mechanisms used by plants to respond to various types of biotic and environmental stress.

Shigyo et al. 2006: AP2/EREBP genes are divided into two subfamilies: AP2 genes with two AP2 domains and EREBP genes with a single AP2/ERF (Ethylene Responsive Element Binding Factor) domain. Expressions of AP2-like genes, including AP2, in Arabidopsis thaliana are regulated by the microRNA miR172. We found that the target site of miR172 is significantly conserved in gymnosperm AP2 homologs, suggesting that regulatory mechanisms of gene expression using microRNA have been conserved over the three hundred million years since the divergence of gymnosperm and flowering plant lineages.

Members of this family
  SHOULD possess AP2 domain

Domain alignments

Benchmark against A. thaliana

The Sensitivity and Positive Predictive Value (PPV) were assessed for this family. The data reported by Feng et al. 2005 for A. thaliana were taken as gold standard.

The gold standard reported 147 members for this family, 146 of which are present in ArabTFDB, giving a PPV of 1.00. One additional member not present in ArabTFDB might be a false negative, giving a Sensitivity of 0.99.

This family is also present in:

References

There are 168 gene models in this family



Gene modelDescriptionDomains
AT1G01250.1 AP2 domain-containing transcription factor, putative AP2
AT1G03800.1 ATERF10/ERF10 (ERF domain protein 10); DNA binding / transcription factor/ transcription repressor AP2
AT1G04370.1 ATERF14 (ETHYLENE-RESPONSIVE ELEMENT BINDING FACTOR 14); DNA binding / transcription factor AP2
AT1G06160.1 ethylene-responsive factor, putative AP2
AT1G12610.1 DDF1 (DWARF AND DELAYED FLOWERING 1); DNA binding / transcription factor AP2
AT1G12630.1 DNA binding / transcription activator/ transcription factor AP2
AT1G12890.1 AP2 domain-containing transcription factor, putative AP2
AT1G12980.1 ESR1 (ENHANCER OF SHOOT REGENERATION 1); DNA binding / transcription factor AP2
AT1G13260.1 RAV1 (Related to ABI3/VP1 1); DNA binding / transcription factor AP2 B3
AT1G15360.1 SHN1/WIN1 (SHINE1); DNA binding / transcription factor AP2
AT1G16060.1 ovule development protein, putative AP2
AT1G16060.2 ovule development protein, putative AP2
AT1G19210.1 AP2 domain-containing transcription factor, putative AP2
AT1G21910.1 AP2 domain-containing transcription factor family protein AP2
AT1G22190.1 AP2 domain-containing transcription factor, putative AP2
AT1G22810.1 AP2 domain-containing transcription factor, putative AP2
AT1G22985.1 AP2 domain-containing transcription factor, putative AP2
AT1G24590.1 DRNL (DORNROSCHEN-LIKE); DNA binding / transcription factor AP2
AT1G25470.1 AP2 domain-containing transcription factor, putative AP2
AT1G25470.2 AP2 domain-containing transcription factor, putative AP2
AT1G25560.1 AP2 domain-containing transcription factor, putative AP2 B3
AT1G28160.1 ethylene-responsive element-binding family protein AP2
AT1G28360.1 ATERF12/ERF12 (ERF domain protein 12); DNA binding / transcription factor/ transcription repressor AP2
AT1G28370.1 ATERF11/ERF11 (ERF domain protein 11); DNA binding / transcription factor/ transcription repressor AP2
AT1G33760.1 AP2 domain-containing transcription factor, putative AP2
AT1G36060.1 AP2 domain-containing transcription factor, putative AP2
AT1G43160.1 RAP2.6 (related to AP2 6); DNA binding / transcription factor AP2
AT1G44830.1 AP2 domain-containing transcription factor TINY, putative AP2
AT1G46768.1 RAP2.1 (related to AP2 1); DNA binding / transcription factor AP2
AT1G49120.1 AP2 domain-containing transcription factor, putative AP2
AT1G50640.1 ATERF3/ERF3 (ETHYLENE RESPONSIVE ELEMENT BINDING FACTOR 3); DNA binding / protein binding / transcription factor/ transcription repressor AP2
AT1G50680.1 AP2 domain-containing transcription factor, putative AP2 B3
AT1G51120.1 AP2 domain-containing transcription factor, putative AP2 B3
AT1G51190.1 PLT2 (PLETHORA 2); transcription factor AP2
AT1G53170.1 ATERF-8/ATERF8 (ETHYLENE RESPONSE ELEMENT BINDING FACTOR 4); DNA binding / transcription factor/ transcription repressor AP2
AT1G53910.1 RAP2.12; DNA binding / transcription factor AP2
AT1G53910.2 RAP2.12; DNA binding / transcription factor AP2
AT1G53910.3 RAP2.12 AP2
AT1G63030.1 DDF2 (DWARF AND DELAYED FLOWERING 2); DNA binding / transcription factor AP2
AT1G63030.2 DDF2 (DWARF AND DELAYED FLOWERING 2) AP2
AT1G64380.1 AP2 domain-containing transcription factor, putative AP2
AT1G68550.1 AP2 domain-containing transcription factor, putative AP2
AT1G68550.2 AP2 domain-containing transcription factor, putative AP2
AT1G68840.1 RAV2 (REGULATOR OF THE ATPASE OF THE VACUOLAR MEMBRANE); DNA binding / transcription factor AP2 B3
AT1G71130.1 AP2 domain-containing transcription factor, putative AP2
AT1G71450.1 AP2 domain-containing transcription factor, putative AP2
AT1G71520.1 AP2 domain-containing transcription factor, putative AP2
AT1G72360.1 ethylene-responsive element-binding protein, putative AP2
AT1G72360.2 ethylene-responsive element-binding protein, putative AP2
AT1G72360.3 ethylene-responsive element-binding protein, putative AP2
AT1G72570.1 DNA binding / transcription factor AP2
AT1G74930.1 ORA47; DNA binding / transcription factor AP2
AT1G75490.1 DNA binding / transcription factor AP2
AT1G77200.1 AP2 domain-containing transcription factor TINY, putative AP2
AT1G77640.1 AP2 domain-containing transcription factor, putative AP2
AT1G78080.1 RAP2.4 (related to AP2 4); DNA binding / transcription factor AP2
AT1G79700.1 ovule development protein, putative AP2
AT1G79700.2 ovule development protein, putative AP2
AT1G80580.1 ethylene-responsive element-binding family protein AP2
AT2G20350.1 AP2 domain-containing transcription factor, putative AP2
AT2G20880.1 AP2 domain-containing transcription factor, putative AP2
AT2G22200.1 AP2 domain-containing transcription factor AP2
AT2G23340.1 AP2 domain-containing transcription factor, putative AP2
AT2G25820.1 transcription factor AP2
AT2G28550.1 RAP2.7/TOE1 (TARGET OF EAT1 1); DNA binding / transcription factor AP2
AT2G28550.2 RAP2.7/TOE1 (TARGET OF EAT1 1); DNA binding / transcription factor AP2
AT2G31230.1 ATERF15 (ETHYLENE-RESPONSIVE ELEMENT BINDING FACTOR 15); DNA binding / transcription activator/ transcription factor AP2
AT2G33710.1 AP2 domain-containing transcription factor family protein AP2
AT2G35700.1 AP2 domain-containing transcription factor, putative AP2
AT2G36450.1 HRD (HARDY); DNA binding / transcription activator/ transcription factor AP2
AT2G38340.1 AP2 domain-containing transcription factor, putative (DRE2B) AP2
AT2G39250.1 SNZ (SCHNARCHZAPFEN); DNA binding / transcription factor AP2
AT2G40220.1 ABI4 (ABA INSENSITIVE 4); DNA binding / transcription factor AP2
AT2G40340.1 AP2 domain-containing transcription factor, putative (DRE2B) AP2
AT2G40350.1 DNA binding / transcription factor AP2
AT2G41710.1 ovule development protein, putative AP2
AT2G41710.2 ovule development protein, putative AP2
AT2G44840.1 ATERF13/EREBP (ETHYLENE-RESPONSIVE ELEMENT BINDING FACTOR 13); DNA binding / transcription factor AP2
AT2G44940.1 AP2 domain-containing transcription factor TINY, putative AP2
AT2G46310.1 CRF5 (CYTOKININ RESPONSE FACTOR 5); DNA binding / transcription factor AP2
AT2G47520.1 AP2 domain-containing transcription factor, putative AP2
AT3G11020.1 DREB2B (DRE-binding protein 2B); DNA binding / transcription activator/ transcription factor AP2
AT3G14230.1 RAP2.2; DNA binding / transcription factor AP2
AT3G14230.2 RAP2.2; DNA binding / transcription factor AP2
AT3G14230.3 RAP2.2; DNA binding / transcription factor AP2
AT3G15210.1 ATERF-4/ATERF4/ERF4/RAP2.5 (ETHYLENE RESPONSIVE ELEMENT BINDING FACTOR 4); DNA binding / protein binding / transcription factor/ transcription repressor AP2
AT3G16280.1 DNA binding / transcription factor AP2
AT3G16770.1 ATEBP/ERF72/RAP2.3 (RELATED TO AP2 3); DNA binding / protein binding / transcription activator/ transcription factor AP2
AT3G20310.1 ATERF-7/ATERF7/ERF7 (ETHYLINE RESPONSE FACTOR7); DNA binding / protein binding / transcription factor/ transcription repressor AP2
AT3G20840.1 PLT1 (PLETHORA 1); transcription factor AP2
AT3G23220.1 DNA binding / transcription factor AP2
AT3G23230.1 ethylene-responsive factor, putative AP2
AT3G23240.1 ATERF1/ERF1 (ETHYLENE RESPONSE FACTOR 1); DNA binding / transcription activator/ transcription factor AP2
AT3G25730.1 AP2 domain-containing transcription factor, putative AP2 B3
AT3G25890.1 AP2 domain-containing transcription factor, putative AP2
AT3G25890.2 AP2 domain-containing transcription factor, putative AP2
AT3G50260.1 ATERF#011/CEJ1 (COOPERATIVELY REGULATED BY ETHYLENE AND JASMONATE 1); DNA binding / transcription factor AP2
AT3G54320.1 WRI1 (WRINKLED 1); DNA binding / transcription factor AP2
AT3G54320.2 WRI1 (WRINKLED 1); DNA binding / transcription factor AP2
AT3G54320.3 WRI1 (WRINKLED 1); DNA binding / transcription factor AP2
AT3G54990.1 SMZ (SCHLAFMUTZE); DNA binding / transcription factor AP2
AT3G54990.2 SMZ (SCHLAFMUTZE) AP2
AT3G57600.1 AP2 domain-containing transcription factor, putative AP2
AT3G60490.1 AP2 domain-containing transcription factor TINY, putative AP2
AT3G61630.1 CRF6 (CYTOKININ RESPONSE FACTOR 6); DNA binding / transcription factor AP2
AT4G06746.1 RAP2.9 (related to AP2 9); transcription factor AP2
AT4G11140.1 CRF1 (CYTOKININ RESPONSE FACTOR 1); DNA binding / transcription factor AP2
AT4G13040.1 AP2 domain-containing transcription factor family protein AP2
AT4G13040.2 AP2 domain-containing transcription factor family protein AP2
AT4G13620.1 AP2 domain-containing transcription factor, putative AP2
AT4G16750.1 DRE-binding transcription factor, putative AP2
AT4G17490.1 ATERF6 (ETHYLENE RESPONSIVE ELEMENT BINDING FACTOR 6); DNA binding / transcription factor AP2
AT4G17500.1 ATERF-1 (ETHYLENE RESPONSIVE ELEMENT BINDING FACTOR 1); DNA binding / transcription activator/ transcription factor AP2
AT4G18450.1 ethylene-responsive factor, putative AP2
AT4G23750.1 CRF2 (CYTOKININ RESPONSE FACTOR 2); DNA binding / transcription factor AP2
AT4G23750.2 CRF2 (CYTOKININ RESPONSE FACTOR 2); DNA binding / transcription factor AP2
AT4G25470.1 CBF2 (FREEZING TOLERANCE QTL 4); DNA binding / transcription activator/ transcription factor AP2
AT4G25480.1 DREB1A (DEHYDRATION RESPONSE ELEMENT B1A); DNA binding / transcription activator/ transcription factor AP2
AT4G25490.1 CBF1 (C-REPEAT/DRE BINDING FACTOR 1); DNA binding / transcription activator/ transcription factor AP2
AT4G27950.1 CRF4 (CYTOKININ RESPONSE FACTOR 4); DNA binding / transcription factor AP2
AT4G28140.1 AP2 domain-containing transcription factor, putative AP2
AT4G31060.1 AP2 domain-containing transcription factor, putative AP2
AT4G32800.1 AP2 domain-containing transcription factor TINY, putative AP2
AT4G34410.1 AP2 domain-containing transcription factor, putative AP2
AT4G36900.1 RAP2.10 (related to AP2 10); DNA binding / transcription factor AP2
AT4G36920.1 AP2 (APETALA 2); transcription factor AP2
AT4G37750.1 ANT (AINTEGUMENTA); DNA binding / transcription factor AP2
AT4G39780.1 AP2 domain-containing transcription factor, putative AP2
AT5G05410.1 DREB2A (DRE-BINDING PROTEIN 2A); DNA binding / transcription activator/ transcription factor AP2
AT5G05410.2 DREB2A (DRE-BINDING PROTEIN 2A); DNA binding / transcription activator/ transcription factor AP2
AT5G07310.1 AP2 domain-containing transcription factor, putative AP2
AT5G07580.1 DNA binding / transcription factor AP2
AT5G10510.1 AIL6 (AINTEGUMENTA-LIKE 6); DNA binding / transcription factor AP2
AT5G10510.2 AIL6 (AINTEGUMENTA-LIKE 6) AP2
AT5G11190.1 SHN3 (SHINE3); DNA binding / transcription factor AP2
AT5G11590.1 TINY2 (TINY2); DNA binding / transcription factor AP2
AT5G13330.1 RAP2.6L (related to AP2 6L); DNA binding / transcription factor AP2
AT5G13910.1 LEP (LEAFY PETIOLE); DNA binding / transcription factor AP2
AT5G17430.1 DNA binding / transcription factor AP2
AT5G18450.1 AP2 domain-containing transcription factor, putative AP2
AT5G18560.1 PUCHI; DNA binding / transcription factor AP2
AT5G19790.1 RAP2.11 (related to AP2 11); DNA binding / transcription factor AP2
AT5G21960.1 AP2 domain-containing transcription factor, putative AP2
AT5G25190.1 ethylene-responsive element-binding protein, putative AP2
AT5G25390.1 SHN2 (SHINE2); DNA binding / transcription factor AP2
AT5G25390.2 SHN2 (SHINE2); DNA binding / transcription factor AP2
AT5G25810.1 TNY (TINY); DNA binding / transcription factor AP2
AT5G43410.1 ethylene-responsive factor, putative AP2
AT5G44210.1 ATERF-9/ATERF9/ERF9 (ERF domain protein 9); DNA binding / transcription factor/ transcription repressor AP2
AT5G47220.1 ATERF-2/ATERF2/ERF2 (ETHYLENE RESPONSE FACTOR 2); DNA binding / transcription activator/ transcription factor AP2
AT5G47230.1 ERF5 (ETHYLENE RESPONSIVE ELEMENT BINDING FACTOR 5); DNA binding / transcription activator/ transcription factor AP2
AT5G50080.1 DNA binding / transcription factor AP2
AT5G51190.1 AP2 domain-containing transcription factor, putative AP2
AT5G51990.1 CBF4/DREB1D (C- REPEAT-BINDING FACTOR 4); DNA binding / transcription activator/ transcription factor AP2
AT5G52020.1 AP2 domain-containing protein AP2
AT5G53290.1 CRF3 (CYTOKININ RESPONSE FACTOR 3); DNA binding / transcription factor AP2
AT5G57390.1 AIL5 (AINTEGUMENTA-LIKE 5); DNA binding / transcription factor AP2
AT5G60120.1 TOE2 (TARGET OF EAT1 2); DNA binding / transcription factor AP2
AT5G61590.1 AP2 domain-containing transcription factor family protein AP2
AT5G61600.1 ethylene-responsive element-binding family protein AP2
AT5G61890.1 AP2 domain-containing transcription factor family protein AP2
AT5G64750.1 ABR1 (ABA REPRESSOR1); DNA binding / transcription factor AP2
AT5G65130.1 AP2 domain-containing transcription factor, putative AP2
AT5G65510.1 AIL7 (AINTEGUMENTA-LIKE 7); DNA binding / transcription factor AP2
AT5G67000.1 DNA binding / transcription factor AP2
AT5G67010.1 AP2 domain-containing transcription factor, putative AP2
AT5G67180.1 AP2 domain-containing transcription factor, putative AP2
AT5G67190.1 AP2 domain-containing transcription factor, putative AP2

General references

Gutterson, N; Reuber, TL. 2004. Regulation of disease resistance pathways by AP2/ERF transcription factors. Curr. Opin. Plant Biol. 7(4):465-71 PUBMEDID:15231271
Liu, Y; Zhao, TJ; Liu, JM; Liu, WQ; Liu, Q; Yan, YB; Zhou, HM. 2006. The conserved Ala37 in the ERF/AP2 domain is essential for binding with the DRE element and the GCC box. FEBS Lett. 580(5):1303-8 PUBMEDID:16457823
Magnani, E; Sjölander, K; Hake, S. 2004. From endonucleases to transcription factors: evolution of the AP2 DNA binding domain in plants. Plant Cell 16(9):2265-77 PUBMEDID:15319480
Ohme-Takagi, M; Shinshi, H. 1995. Ethylene-inducible DNA binding proteins that interact with an ethylene-responsive element. Plant Cell 7(2):173-82 PUBMEDID:7756828
Riechmann, JL; Meyerowitz, EM. 1998. The AP2/EREBP family of plant transcription factors. Biol. Chem. 379(6):633-46 PUBMEDID:9687012
Shigyo, M; Hasebe, M; Ito, M. 2006. Molecular evolution of the AP2 subfamily. Gene 366(2):256-65 PUBMEDID:16388920
Shigyo, M; Ito, M. 2004. Analysis of gymnosperm two-AP2-domain-containing genes. Dev. Genes Evol. 214(3):105-14 PUBMEDID:14986134
Weigel, D. 1995. The APETALA2 domain is related to a novel type of DNA binding domain. Plant Cell 7(4):388-9 PUBMEDID:7773013

Specific references

Feng, JX; Liu, D; Pan, Y; Gong, W; Ma, LG; Luo, JC; Deng, XW; Zhu, YX. 2005. An annotation update via cDNA sequence analysis and comprehensive profiling of developmental, hormonal or environmental responsiveness of the Arabidopsis AP2/EREBP transcription factor gene family. Plant Mol. Biol. 59(6):853-68 PUBMEDID:16307362
Liu, Q; Kasuga, M; Sakuma, Y; Abe, H; Miura, S; Yamaguchi-Shinozaki, K; Shinozaki, K. 1998. Two transcription factors, DREB1 and DREB2, with an EREBP/AP2 DNA binding domain separate two cellular signal transduction pathways in drought- and low-temperature-responsive gene expression, respectively, in Arabidopsis. Plant Cell 10(8):1391-406 PUBMEDID:9707537
Okamuro, JK; Caster, B; Villarroel, R; Van Montagu, M; Jofuku, KD. 1997. The AP2 domain of APETALA2 defines a large new family of DNA binding proteins in Arabidopsis. Proc. Natl. Acad. Sci. U.S.A. 94(13):7076-81 PUBMEDID:9192694
Sakuma, Y; Liu, Q; Dubouzet, JG; Abe, H; Shinozaki, K; Yamaguchi-Shinozaki, K. 2002. DNA-binding specificity of the ERF/AP2 domain of Arabidopsis DREBs, transcription factors involved in dehydration- and cold-inducible gene expression. Biochem. Biophys. Res. Commun. 290(3):998-1009 PUBMEDID:11798174