Plant Transcription factor database - Universität Potsdam
version: 3.0

Physcomitrella patens AP2-EREBP Family


Riechmann & Meyerowitz. 1998: AP2 (APETALA2) and EREBPs (ethylene-responsive element binding proteins) are the prototypic members of a family of transcription factors unique to plants, whose distinguishing characteristic is that they contain the so-called AP2 DNA-binding domain. AP2/ REBP genes form a large multigene family, and they play a variety of roles throughout the plant life cycle: from being key regulators of several developmental processes, like floral organ identity determination or control of leaf epidermal cell identity, to forming part of the mechanisms used by plants to respond to various types of biotic and environmental stress.

Shigyo et al. 2006: AP2/EREBP genes are divided into two subfamilies: AP2 genes with two AP2 domains and EREBP genes with a single AP2/ERF (Ethylene Responsive Element Binding Factor) domain. Expressions of AP2-like genes, including AP2, in Arabidopsis thaliana are regulated by the microRNA miR172. We found that the target site of miR172 is significantly conserved in gymnosperm AP2 homologs, suggesting that regulatory mechanisms of gene expression using microRNA have been conserved over the three hundred million years since the divergence of gymnosperm and flowering plant lineages.

Members of this family
  SHOULD possess AP2 domain

Domain alignments

Benchmark against A. thaliana

The Sensitivity and Positive Predictive Value (PPV) were assessed for this family. The data reported by Feng et al. 2005 for A. thaliana were taken as gold standard.

The gold standard reported 147 members for this family, 146 of which are present in ArabTFDB, giving a PPV of 1.00. One additional member not present in ArabTFDB might be a false negative, giving a Sensitivity of 0.99.

This family is also present in:


There are 149 gene models in this family

Gene modelDescriptionDomains
111656 e_gw1.2.353.1 AP2
111672 e_gw1.2.434.1 AP2
112927 e_gw1.5.258.1 AP2
113756 e_gw1.7.264.1 AP2
115843 e_gw1.14.213.1 AP2
116117 e_gw1.15.309.1 AP2
116338 e_gw1.15.234.1 AP2
117141 e_gw1.19.142.1 AP2
117468 e_gw1.20.254.1 AP2
117647 e_gw1.21.123.1 AP2
117713 e_gw1.21.268.1 AP2
119921 e_gw1.30.170.1 AP2
119930 e_gw1.31.217.1 AP2
120350 e_gw1.32.189.1 AP2
122807 e_gw1.41.124.1 AP2
125236 e_gw1.53.114.1 AP2
126548 e_gw1.60.212.1 AP2
126573 e_gw1.60.113.1 AP2
127150 e_gw1.63.77.1 AP2 B3
127290 e_gw1.64.98.1 AP2
127673 e_gw1.66.94.1 AP2
127688 e_gw1.66.73.1 AP2
128717 e_gw1.72.116.1 AP2
128856 e_gw1.72.241.1 AP2
129196 e_gw1.74.130.1 AP2
134515 e_gw1.112.90.1 AP2
135129 e_gw1.117.76.1 AP2
135936 e_gw1.124.59.1 AP2
136724 e_gw1.131.48.1 AP2
137488 e_gw1.138.99.1 AP2
138308 e_gw1.145.79.1 AP2
138640 e_gw1.149.152.1 AP2
139961 e_gw1.162.74.1 AP2
141705 e_gw1.181.96.1 AP2
142112 e_gw1.187.17.1 AP2
142710 e_gw1.195.59.1 AP2
145755 e_gw1.233.44.1 AP2
147502 e_gw1.261.8.1 AP2
147709 e_gw1.265.11.1 AP2
148338 e_gw1.276.69.1 AP2
149195 e_gw1.292.36.1 AP2
149320 e_gw1.294.48.1 AP2
150462 e_gw1.317.27.1 AP2
151367 e_gw1.335.26.1 AP2
151802 e_gw1.345.20.1 AP2
152222 e_gw1.357.22.1 AP2
155840 e_gw1.487.2.1 AP2
158750 estExt_fgenesh1_pg.C_60051 AP2
159296 estExt_fgenesh1_pg.C_110162 AP2
159751 estExt_fgenesh1_pg.C_150119 AP2
160018 estExt_fgenesh1_pg.C_170192 AP2
160342 estExt_fgenesh1_pg.C_210126 AP2
160758 estExt_fgenesh1_pg.C_250219 AP2
162837 estExt_fgenesh1_pg.C_470204 AP2
163635 estExt_fgenesh1_pg.C_580142 AP2
163821 estExt_fgenesh1_pg.C_600136 AP2
164899 estExt_fgenesh1_pg.C_790091 AP2
165365 estExt_fgenesh1_pg.C_870058 AP2
165664 estExt_fgenesh1_pg.C_930051 AP2
166250 estExt_fgenesh1_pg.C_1070015 AP2
166576 estExt_fgenesh1_pg.C_1190020 AP2
168390 estExt_fgenesh1_pg.C_1740049 AP2
169663 estExt_fgenesh1_pg.C_2150040 AP2
170406 estExt_fgenesh1_pg.C_2430037 AP2
170820 estExt_fgenesh1_pg.C_2630037 AP2
171511 estExt_fgenesh1_pg.C_2960005 AP2
171520 estExt_fgenesh1_pg.C_2960042 AP2
172697 estExt_fgenesh1_pg.C_3730012 AP2
173369 estExt_fgenesh1_pg.C_4500007 AP2
173530 estExt_fgenesh1_pg.C_4800009 AP2
176040 estExt_gwp_gw1.C_150120 AP2
182268 estExt_gwp_gw1.C_550163 AP2
182480 estExt_gwp_gw1.C_580005 AP2
18737 gw1.183.41.1 AP2
18841 gw1.120.55.1 AP2
189022 estExt_gwp_gw1.C_1270048 AP2
189336 estExt_gwp_gw1.C_1310105 AP2
19432 gw1.126.81.1 AP2
195459 estExt_gwp_gw1.C_2400055 AP2
196844 estExt_gwp_gw1.C_2760033 AP2
19913 gw1.136.88.1 AP2
19915 gw1.115.66.1 AP2
19922 gw1.67.101.1 AP2
19953 gw1.140.37.1 AP2
19955 gw1.160.53.1 AP2
19961 gw1.105.71.1 AP2
223126 estExt_Genewise1.C_2490073 AP2 zf-C2H2
233473 estExt_fgenesh2_pg.C_860008 AP2
25350 gw1.17.139.1 AP2
26371 gw1.480.6.1 AP2
27022 gw1.15.199.1 AP2
27477 gw1.21.122.1 AP2
27769 gw1.7.214.1 AP2
27792 gw1.23.89.1 AP2
27970 gw1.45.95.1 AP2
28324 gw1.8.141.1 AP2
29766 gw1.13.222.1 AP2
29768 gw1.37.164.1 AP2
29777 gw1.25.154.1 AP2
29806 gw1.26.141.1 AP2
29819 gw1.2.360.1 AP2
29825 gw1.6.206.1 AP2
29826 gw1.2.361.1 AP2
29828 gw1.38.156.1 AP2
29829 gw1.14.214.1 AP2
29830 gw1.38.157.1 AP2
36345 gw1.340.39.1 AP2
37306 gw1.81.143.1 AP2
37802 gw1.259.37.1 AP2
37832 gw1.259.39.1 AP2
39058 gw1.132.76.1 AP2
39601 gw1.7.289.1 AP2
39604 gw1.28.290.1 AP2
39606 gw1.133.82.1 AP2
39614 gw1.259.45.1 AP2
39621 gw1.61.159.1 AP2
39624 gw1.121.77.1 AP2
39631 gw1.14.262.1 AP2
45121 gw1.135.126.1 AP2 B3
47175 gw1.14.347.1 AP2
47830 gw1.276.83.1 AP2
48161 gw1.117.121.1 AP2
48356 gw1.90.191.1 AP2
48867 gw1.130.147.1 AP2
49454 gw1.83.240.1 AP2
49506 gw1.55.249.1 AP2
49509 gw1.155.87.1 AP2
64121 fgenesh1_pg.scaffold_1000495 AP2
65352 fgenesh1_pg.scaffold_6000034 AP2
66602 fgenesh1_pg.scaffold_11000121 AP2
69400 fgenesh1_pg.scaffold_23000002 AP2
70654 fgenesh1_pg.scaffold_29000021 AP2
78196 fgenesh1_pg.scaffold_70000013 AP2
79416 fgenesh1_pg.scaffold_79000014 AP2
79984 fgenesh1_pg.scaffold_83000059 AP2
81770 fgenesh1_pg.scaffold_98000021 AP2 zf-C2H2
82857 fgenesh1_pg.scaffold_107000019 AP2
8533 gw1.293.27.1 AP2
8600 gw1.296.16.1 AP2
8690 gw1.221.29.1 AP2
8813 gw1.199.36.1 AP2
89183 fgenesh1_pg.scaffold_179000036 AP2
94562 fgenesh1_pg.scaffold_263000045 AP2
94563 fgenesh1_pg.scaffold_263000046 AP2
95231 fgenesh1_pg.scaffold_276000039 AP2
9733 gw1.289.18.1 AP2
9737 gw1.293.28.1 AP2
9740 gw1.259.19.1 AP2
9783 gw1.204.54.1 AP2

General references

Gutterson, N; Reuber, TL. 2004. Regulation of disease resistance pathways by AP2/ERF transcription factors. Curr. Opin. Plant Biol. 7(4):465-71 PUBMEDID:15231271
Liu, Y; Zhao, TJ; Liu, JM; Liu, WQ; Liu, Q; Yan, YB; Zhou, HM. 2006. The conserved Ala37 in the ERF/AP2 domain is essential for binding with the DRE element and the GCC box. FEBS Lett. 580(5):1303-8 PUBMEDID:16457823
Magnani, E; Sjölander, K; Hake, S. 2004. From endonucleases to transcription factors: evolution of the AP2 DNA binding domain in plants. Plant Cell 16(9):2265-77 PUBMEDID:15319480
Ohme-Takagi, M; Shinshi, H. 1995. Ethylene-inducible DNA binding proteins that interact with an ethylene-responsive element. Plant Cell 7(2):173-82 PUBMEDID:7756828
Riechmann, JL; Meyerowitz, EM. 1998. The AP2/EREBP family of plant transcription factors. Biol. Chem. 379(6):633-46 PUBMEDID:9687012
Shigyo, M; Hasebe, M; Ito, M. 2006. Molecular evolution of the AP2 subfamily. Gene 366(2):256-65 PUBMEDID:16388920
Shigyo, M; Ito, M. 2004. Analysis of gymnosperm two-AP2-domain-containing genes. Dev. Genes Evol. 214(3):105-14 PUBMEDID:14986134
Weigel, D. 1995. The APETALA2 domain is related to a novel type of DNA binding domain. Plant Cell 7(4):388-9 PUBMEDID:7773013