Plant Transcription factor database - Universität Potsdam
version: 3.0

Sorghum bicolor AP2-EREBP Family


Riechmann & Meyerowitz. 1998: AP2 (APETALA2) and EREBPs (ethylene-responsive element binding proteins) are the prototypic members of a family of transcription factors unique to plants, whose distinguishing characteristic is that they contain the so-called AP2 DNA-binding domain. AP2/ REBP genes form a large multigene family, and they play a variety of roles throughout the plant life cycle: from being key regulators of several developmental processes, like floral organ identity determination or control of leaf epidermal cell identity, to forming part of the mechanisms used by plants to respond to various types of biotic and environmental stress.

Shigyo et al. 2006: AP2/EREBP genes are divided into two subfamilies: AP2 genes with two AP2 domains and EREBP genes with a single AP2/ERF (Ethylene Responsive Element Binding Factor) domain. Expressions of AP2-like genes, including AP2, in Arabidopsis thaliana are regulated by the microRNA miR172. We found that the target site of miR172 is significantly conserved in gymnosperm AP2 homologs, suggesting that regulatory mechanisms of gene expression using microRNA have been conserved over the three hundred million years since the divergence of gymnosperm and flowering plant lineages.

Members of this family
  SHOULD possess AP2 domain

Domain alignments

Benchmark against A. thaliana

The Sensitivity and Positive Predictive Value (PPV) were assessed for this family. The data reported by Feng et al. 2005 for A. thaliana were taken as gold standard.

The gold standard reported 147 members for this family, 146 of which are present in ArabTFDB, giving a PPV of 1.00. One additional member not present in ArabTFDB might be a false negative, giving a Sensitivity of 0.99.

This family is also present in:


There are 161 gene models in this family

Gene modelDescriptionDomains
124373 fgenesh1_pm.C_chr_2000141 AP2
124652 fgenesh1_pm.C_chr_2000420 AP2
127436 fgenesh1_pm.C_chr_4000739 AP2
130198 fgenesh1_pm.C_chr_9000515 AP2 B3
132571 fgenesh1_kg.C_chr_4000144 AP2
144846 estExt_fgenesh1_pm.C_chr_41072 AP2
147841 estExt_fgenesh1_kg.C_chr_20235 AP2
148073 estExt_fgenesh1_kg.C_chr_30050 AP2
148086 estExt_fgenesh1_kg.C_chr_30065 AP2 B3
148097 estExt_fgenesh1_kg.C_chr_30077 AP2
148527 estExt_fgenesh1_kg.C_chr_40076 AP2
149293 estExt_fgenesh1_kg.C_chr_70079 AP2
149663 estExt_fgenesh1_kg.C_chr_90106 AP2
149764 estExt_fgenesh1_kg.C_chr_90209 AP2
149826 estExt_fgenesh1_kg.C_chr_90271 AP2
149865 estExt_fgenesh1_kg.C_chr_100018 AP2
3990485 gw1.10.544.1 AP2
3991745 gw1.2.536.1 AP2
4002283 gw1.2.1362.1 AP2
4002307 gw1.2.1364.1 AP2
4002324 gw1.10.1649.1 AP2
4002392 gw1.2.1374.1 AP2
4043834 gw1.10.5875.1 AP2
4044499 gw1.5.5764.1 AP2
4044513 gw1.5.5767.1 AP2
4054528 gw1.1.6554.1 AP2
4114494 gw1.6.13003.1 AP2
4134480 gw1.9.15039.1 AP2
4142282 gw1.5.15565.1 AP2
4142435 gw1.6.15884.1 AP2
4143491 gw1.7.15872.1 AP2
4144418 gw1.6.16085.1 AP2
4144438 gw1.6.16091.1 AP2
4144439 gw1.6.16092.1 AP2
4152416 gw1.1.15911.1 AP2
4152567 gw1.4.16465.1 AP2
4162375 gw1.2.18962.1 AP2
4162377 gw1.1.17927.1 AP2
4162905 gw1.1.18037.1 AP2
4163147 gw1.4.18318.1 AP2
4164387 gw1.4.18545.1 AP2
4164415 gw1.4.18554.1 AP2
4747792 estExt_Genewise1.C_chr_26883 AP2
4751860 estExt_Genewise1.C_chr_32758 AP2
4752992 estExt_Genewise1.C_chr_38285 AP2 B3
4770195 estExt_Genewise1.C_chr_101615 AP2
4778391 e_gw1.1.13941.1 AP2
4779023 e_gw1.1.19549.1 AP2
4781240 e_gw1.1.18178.1 AP2
4781818 e_gw1.1.19401.1 AP2
4786245 e_gw1.2.18990.1 AP2
4794881 e_gw1.2.21065.1 AP2
4802957 e_gw1.3.19043.1 AP2
4806706 e_gw1.3.20828.1 AP2
4808027 e_gw1.4.18433.1 AP2
4809481 e_gw1.4.2610.1 AP2
4812886 e_gw1.4.18238.1 AP2
4816856 e_gw1.4.2786.1 AP2
4823953 e_gw1.5.3644.1 AP2
4829818 e_gw1.6.15771.1 AP2
4831483 e_gw1.6.16089.1 AP2
4832705 e_gw1.6.15741.1 AP2
4834125 e_gw1.7.14719.1 AP2
4834427 e_gw1.7.15572.1 AP2
4840785 e_gw1.7.17109.1 AP2
4842066 e_gw1.7.1694.1 AP2
4850380 e_gw1.9.15902.1 AP2
4853317 e_gw1.9.13226.1 AP2
4862616 e_gw1.10.15576.1 AP2
4867704 estExt_Genewise1Plus.C_chr_11374 AP2
4872111 estExt_Genewise1Plus.C_chr_111085 AP2
4874673 estExt_Genewise1Plus.C_chr_27447 AP2
4884611 estExt_Genewise1Plus.C_chr_48571 AP2
4888514 estExt_Genewise1Plus.C_chr_66700 AP2
4967578 fgenesh1_pg.C_chr_1004180 AP2
4971434 fgenesh1_pg.C_chr_2002750 AP2
4975823 fgenesh1_pg.C_chr_3002938 AP2
4976573 fgenesh1_pg.C_chr_3003688 AP2
4980182 fgenesh1_pg.C_chr_4003015 AP2
4987453 fgenesh1_pg.C_chr_7001543 AP2
4988012 fgenesh1_pg.C_chr_7002102 AP2
4988013 fgenesh1_pg.C_chr_7002103 AP2
4988014 fgenesh1_pg.C_chr_7002104 AP2
4991721 fgenesh1_pg.C_chr_9001449 AP2
4993412 fgenesh1_pg.C_chr_10000589 AP2
4994924 fgenesh1_pg.C_chr_10002101 AP2
4998749 estExt_fgenesh1_pg.C_chr_14621 AP2
4999449 estExt_fgenesh1_pg.C_chr_20777 AP2
4999782 estExt_fgenesh1_pg.C_chr_21705 AP2
4999783 estExt_fgenesh1_pg.C_chr_21706 AP2
5004277 estExt_fgenesh1_pg.C_chr_41960 AP2
5004355 estExt_fgenesh1_pg.C_chr_42095 AP2
5007091 estExt_fgenesh1_pg.C_chr_62436 AP2
5007532 estExt_fgenesh1_pg.C_chr_70528 AP2
5007613 estExt_fgenesh1_pg.C_chr_70730 AP2
5027918 Sb01g000352 AP2
5028682 Sb01g014810 AP2
5029200 Sb01g022380 AP2
5029692 Sb01g031140 AP2
5030249 Sb01g042090 AP2
5030761 Sb10g001490 AP2
5031095 Sb10g006980 AP2
5031901 Sb10g023600 AP2
5032176 Sb10g028110 AP2
5032801 Sb02g006023 AP2
5033823 Sb02g025080 AP2
5034124 Sb02g029550 AP2
5034167 Sb02g030340 AP2
5034993 Sb03g001296 AP2
5035064 Sb03g002630 AP2
5036784 Sb03g037085 AP2
5036945 Sb03g040450 AP2
5037035 Sb03g042110 AP2
5037074 Sb03g042810 AP2
5038333 Sb04g021160 AP2
5038405 Sb04g022245 AP2
5038456 Sb04g022943 AP2
5038952 Sb04g031960 AP2
5039618 Sb05g004170 AP2
5039836 Sb05g006275 AP2
5041081 Sb05g026843 AP2
5041669 Sb06g014800 AP2
5041828 Sb06g016710 AP2
5042232 Sb06g023313 AP2
5042300 Sb06g024540 AP2
5042671 Sb06g031230 AP2
5043516 Sb07g015070 AP2
5043884 Sb07g023030 AP2
5043936 Sb07g023803 AP2
5044020 Sb07g025210 AP2
5044069 Sb07g025843 AP2
5044163 Sb07g027250 AP2
5044593 Sb08g004260 AP2
5045367 Sb08g019530 AP2
5046329 Sb09g016550 AP2
5046594 Sb09g021016 AP2
5046628 Sb09g021540 AP2
5047434 Sb0239s002010 AP2
5047435 Sb0239s002020 AP2
5047840 Sb01g003400 AP2
5049059 Sb01g028930 AP2
5050072 Sb01g045050 AP2
5050095 Sb01g045420 AP2
5050950 Sb02g012630 AP2
5051285 Sb02g026630 AP2
5052031 Sb02g039300 AP2
5052238 Sb02g042760 AP2
5053852 Sb03g037080 AP2
5056004 Sb04g035160 AP2
5056272 Sb05g001280 AP2
5056296 Sb05g001790 AP2
5057633 Sb06g024380 AP2
5057834 Sb06g028090 AP2
5058002 Sb06g030660 AP2
5058003 Sb06g030670 AP2
5058542 Sb07g006190 AP2
5058544 Sb07g006200 AP2
5060013 Sb09g002080 AP2
5060375 Sb09g017950 AP2
5061447 Sb10g006260 AP2
5062039 Sb10g026150 AP2

General references

Gutterson, N; Reuber, TL. 2004. Regulation of disease resistance pathways by AP2/ERF transcription factors. Curr. Opin. Plant Biol. 7(4):465-71 PUBMEDID:15231271
Liu, Y; Zhao, TJ; Liu, JM; Liu, WQ; Liu, Q; Yan, YB; Zhou, HM. 2006. The conserved Ala37 in the ERF/AP2 domain is essential for binding with the DRE element and the GCC box. FEBS Lett. 580(5):1303-8 PUBMEDID:16457823
Magnani, E; Sjölander, K; Hake, S. 2004. From endonucleases to transcription factors: evolution of the AP2 DNA binding domain in plants. Plant Cell 16(9):2265-77 PUBMEDID:15319480
Ohme-Takagi, M; Shinshi, H. 1995. Ethylene-inducible DNA binding proteins that interact with an ethylene-responsive element. Plant Cell 7(2):173-82 PUBMEDID:7756828
Riechmann, JL; Meyerowitz, EM. 1998. The AP2/EREBP family of plant transcription factors. Biol. Chem. 379(6):633-46 PUBMEDID:9687012
Shigyo, M; Hasebe, M; Ito, M. 2006. Molecular evolution of the AP2 subfamily. Gene 366(2):256-65 PUBMEDID:16388920
Shigyo, M; Ito, M. 2004. Analysis of gymnosperm two-AP2-domain-containing genes. Dev. Genes Evol. 214(3):105-14 PUBMEDID:14986134
Weigel, D. 1995. The APETALA2 domain is related to a novel type of DNA binding domain. Plant Cell 7(4):388-9 PUBMEDID:7773013