Plant Transcription factor database - Universität Potsdam
version: 3.0

Selaginella moellendorffii AP2-EREBP Family


Riechmann & Meyerowitz. 1998: AP2 (APETALA2) and EREBPs (ethylene-responsive element binding proteins) are the prototypic members of a family of transcription factors unique to plants, whose distinguishing characteristic is that they contain the so-called AP2 DNA-binding domain. AP2/ REBP genes form a large multigene family, and they play a variety of roles throughout the plant life cycle: from being key regulators of several developmental processes, like floral organ identity determination or control of leaf epidermal cell identity, to forming part of the mechanisms used by plants to respond to various types of biotic and environmental stress.

Shigyo et al. 2006: AP2/EREBP genes are divided into two subfamilies: AP2 genes with two AP2 domains and EREBP genes with a single AP2/ERF (Ethylene Responsive Element Binding Factor) domain. Expressions of AP2-like genes, including AP2, in Arabidopsis thaliana are regulated by the microRNA miR172. We found that the target site of miR172 is significantly conserved in gymnosperm AP2 homologs, suggesting that regulatory mechanisms of gene expression using microRNA have been conserved over the three hundred million years since the divergence of gymnosperm and flowering plant lineages.

Members of this family
  SHOULD possess AP2 domain

Domain alignments

Benchmark against A. thaliana

The Sensitivity and Positive Predictive Value (PPV) were assessed for this family. The data reported by Feng et al. 2005 for A. thaliana were taken as gold standard.

The gold standard reported 147 members for this family, 146 of which are present in ArabTFDB, giving a PPV of 1.00. One additional member not present in ArabTFDB might be a false negative, giving a Sensitivity of 0.99.

This family is also present in:


There are 57 gene models in this family

Gene modelDescriptionDomains
104978 e_gw1.30.112.1 AP2
104980 e_gw1.30.536.1 AP2
110104 e_gw1.39.430.1 AP2 B3
129793 e_gw1.97.73.1 AP2
131245 e_gw1.105.77.1 AP2
17086 gw1.24.199.1 AP2
17087 gw1.47.164.1 AP2
17648 gw1.59.119.1 AP2
17708 gw1.20.232.1 AP2
19889 gw1.22.165.1 AP2
19890 gw1.38.178.1 AP2
26594 gw1.30.164.1 AP2
27203 gw1.0.866.1 AP2
38494 gw1.11.634.1 AP2
38500 gw1.9.589.1 AP2
38502 gw1.21.336.1 AP2
402810 fgenesh2_pg.C_scaffold_0000815 AP2
403257 fgenesh2_pg.C_scaffold_1000094 AP2
404338 fgenesh2_pg.C_scaffold_2000326 AP2
404737 fgenesh2_pg.C_scaffold_2000725 AP2
409196 fgenesh2_pg.C_scaffold_10000094 AP2
411646 fgenesh2_pg.C_scaffold_15000248 AP2
412693 fgenesh2_pg.C_scaffold_18000269 AP2
415574 fgenesh2_pg.C_scaffold_27000188 AP2
428344 fgenesh2_pg.C_scaffold_101000021 AP2
440731 estExt_fgenesh2_pg.C_120106 AP2 F_bP_aldolase NAD_binding_2
443366 estExt_fgenesh2_pg.C_320145 AP2
443461 estExt_fgenesh2_pg.C_330199 AP2 RNA_pol_Rpb2_1 RNA_pol_Rpb2_2 RNA_pol_Rpb2_3 RNA_pol_Rpb2_4 RNA_pol_Rpb2_5 RNA_pol_Rpb2_6 RNA_pol_Rpb2_7
48904 gw1.0.1568.1 AP2
49950 gw1.85.227.1 AP2
49951 gw1.59.458.1 AP2
68470 gw1.0.1788.1 AP2
69413 gw1.1.1950.1 AP2
71153 gw1.0.2475.1 AP2 B3
71661 gw1.114.192.1 AP2
72871 gw1.8.1646.1 AP2
72880 gw1.22.574.1 AP2
73134 gw1.57.527.1 AP2
73136 gw1.4.1719.1 AP2
73138 gw1.3.1693.1 AP2
73140 gw1.26.779.1 AP2
73146 gw1.4.1720.1 AP2
73148 gw1.39.555.1 AP2
73155 gw1.0.2869.1 AP2
73157 gw1.13.1083.1 AP2
73160 gw1.3.1694.1 AP2
73164 gw1.10.1175.1 AP2
73165 gw1.14.1020.1 AP2
73177 gw1.10.1176.1 AP2
73232 gw1.46.394.1 AP2
73854 e_gw1.0.2871.1 AP2
78076 e_gw1.2.526.1 AP2
80895 e_gw1.4.804.1 AP2
85823 e_gw1.7.274.1 AP2
92334 e_gw1.13.1010.1 AP2
96572 e_gw1.18.211.1 AP2
98831 e_gw1.21.337.1 AP2

General references

Gutterson, N; Reuber, TL. 2004. Regulation of disease resistance pathways by AP2/ERF transcription factors. Curr. Opin. Plant Biol. 7(4):465-71 PUBMEDID:15231271
Liu, Y; Zhao, TJ; Liu, JM; Liu, WQ; Liu, Q; Yan, YB; Zhou, HM. 2006. The conserved Ala37 in the ERF/AP2 domain is essential for binding with the DRE element and the GCC box. FEBS Lett. 580(5):1303-8 PUBMEDID:16457823
Magnani, E; Sjölander, K; Hake, S. 2004. From endonucleases to transcription factors: evolution of the AP2 DNA binding domain in plants. Plant Cell 16(9):2265-77 PUBMEDID:15319480
Ohme-Takagi, M; Shinshi, H. 1995. Ethylene-inducible DNA binding proteins that interact with an ethylene-responsive element. Plant Cell 7(2):173-82 PUBMEDID:7756828
Riechmann, JL; Meyerowitz, EM. 1998. The AP2/EREBP family of plant transcription factors. Biol. Chem. 379(6):633-46 PUBMEDID:9687012
Shigyo, M; Hasebe, M; Ito, M. 2006. Molecular evolution of the AP2 subfamily. Gene 366(2):256-65 PUBMEDID:16388920
Shigyo, M; Ito, M. 2004. Analysis of gymnosperm two-AP2-domain-containing genes. Dev. Genes Evol. 214(3):105-14 PUBMEDID:14986134
Weigel, D. 1995. The APETALA2 domain is related to a novel type of DNA binding domain. Plant Cell 7(4):388-9 PUBMEDID:7773013