Plant Transcription factor database - Universität Potsdam
version: 3.0

Arabidopsis thaliana AUX/IAA Family

Description

Tiwari et al. 2004: Aux/IAA proteins are short-lived nuclear proteins that repress expression of primary/early auxin response genes in protoplast transfection assays. Repression is thought to result from Aux/IAA proteins dimerizing with auxin response factor (ARF) transcriptional activators that reside on auxin-responsive promoter elements, referred to as AuxREs. Most Aux/IAA proteins contain four conserved domains, designated domains I, II, III, and IV. Domain II and domains III and IV play roles in protein stability and dimerization, respectively. A clear function for domain I had not been established. Results reported here indicate that domain I in Aux/IAA proteins is an active repression domain that is transferable and dominant over activation domains. An LxLxL motif within domain I is important for conferring repression. The dominance of Aux/IAA repression domains over activation domains in ARF transcriptional activators provides a plausible explanation for the repression of auxin response genes via ARF-Aux/IAA dimerization on auxin-responsive promoters.

Members of this family
  SHOULD possess AUX_IAA domain
  SHOULD NOT possess Auxin_resp B3 domains

Domain alignments

Benchmark against A. thaliana

The Sensitivity and Positive Predictive Value (PPV) were assessed for this family. The data reported by Remington et al. 2004 for A. thaliana were taken as gold standard.

The gold standard reported 29 members for this family, 28 of which are present in ArabTFDB, giving a PPV of 1.00. One additional member not present in ArabTFDB might be a false negative, giving a Sensitivity of 0.97.

This family is also present in:

References

There are 36 gene models in this family



Gene modelDescriptionDomains
AT1G04100.1 IAA10 (indoleacetic acid-induced protein 10); transcription factor AUX_IAA
AT1G04240.1 SHY2 (SHORT HYPOCOTYL 2); transcription factor AUX_IAA
AT1G04250.1 AXR3 (AUXIN RESISTANT 3); transcription factor AUX_IAA
AT1G04550.1 IAA12 (AUXIN-INDUCED PROTEIN 12); transcription factor AUX_IAA
AT1G04550.2 IAA12 (AUXIN-INDUCED PROTEIN 12); transcription factor AUX_IAA
AT1G15050.1 IAA34 (indoleacetic acid-induced protein 34); transcription factor AUX_IAA
AT1G15580.1 IAA5 (indoleacetic acid-induced protein 5); transcription factor AUX_IAA
AT1G51950.1 IAA18 (indoleacetic acid-induced protein 18); transcription factor AUX_IAA
AT1G52830.1 IAA6 (indoleacetic acid-induced protein 6); transcription factor AUX_IAA
AT1G80390.1 IAA15 (indoleacetic acid-induced protein 15); transcription factor AUX_IAA
AT2G01200.2 IAA32 (INDOLEACETIC ACID-INDUCED PROTEIN 32) AUX_IAA
AT2G22670.1 IAA8 (indoleacetic acid-induced protein 8); transcription factor AUX_IAA
AT2G22670.2 IAA8 (indoleacetic acid-induced protein 8); transcription factor AUX_IAA
AT2G22670.3 IAA8 (indoleacetic acid-induced protein 8) AUX_IAA
AT2G33310.1 IAA13 (indoleacetic acid-induced protein 13); transcription factor AUX_IAA
AT2G33310.2 IAA13 (indoleacetic acid-induced protein 13); transcription factor AUX_IAA
AT2G33310.3 IAA13 (indoleacetic acid-induced protein 13) AUX_IAA
AT2G46990.1 IAA20 (indoleacetic acid-induced protein 20); transcription factor AUX_IAA
AT3G04730.1 IAA16 (indoleacetic acid-induced protein 16); transcription factor AUX_IAA
AT3G15540.1 IAA19 (indoleacetic acid-induced protein 19); transcription factor AUX_IAA
AT3G16500.1 PAP1 (PHYTOCHROME-ASSOCIATED PROTEIN 1); transcription factor AUX_IAA
AT3G17600.1 IAA31 (indoleacetic acid-induced protein 31); transcription factor AUX_IAA
AT3G23030.1 IAA2 (indoleacetic acid-induced protein 2); transcription factor AUX_IAA
AT3G23050.1 IAA7 (AUXIN RESISTANT 2); transcription factor AUX_IAA
AT3G23050.2 IAA7 (AUXIN RESISTANT 2) AUX_IAA
AT3G62100.1 IAA30 (indoleacetic acid-induced protein 30); transcription factor AUX_IAA
AT4G14550.1 IAA14 (SOLITARY ROOT); transcription factor AUX_IAA
AT4G14560.1 IAA1 (INDOLE-3-ACETIC ACID INDUCIBLE); transcription factor AUX_IAA
AT4G28640.1 IAA11 (indoleacetic acid-induced protein 11); transcription factor AUX_IAA
AT4G28640.2 IAA11 (indoleacetic acid-induced protein 11) AUX_IAA
AT4G29080.1 PAP2 (PHYTOCHROME-ASSOCIATED PROTEIN 2); transcription factor AUX_IAA
AT4G32280.1 IAA29 (indoleacetic acid-induced protein 29); transcription factor AUX_IAA
AT5G25890.1 IAA28 (IAA-ALANINE RESISTANT 2); transcription factor AUX_IAA
AT5G43700.1 ATAUX2-11 (indoleacetic acid-induced protein 4); transcription factor AUX_IAA
AT5G65670.1 IAA9 (indoleacetic acid-induced protein 9); transcription factor AUX_IAA
AT5G65670.2 IAA9 (indoleacetic acid-induced protein 9); transcription factor AUX_IAA

General references

Liscum, E; Reed, JW. 2002. Genetics of Aux/IAA and ARF action in plant growth and development. Plant Mol. Biol. 49(3-4):387-400 PUBMEDID:12036262
Tiwari, SB; Hagen, G; Guilfoyle, TJ. 2004. Aux/IAA proteins contain a potent transcriptional repression domain. Plant Cell 16(2):533-43 PUBMEDID:14742873
Tiwari, SB; Wang, XJ; Hagen, G; Guilfoyle, TJ. 2001. AUX/IAA proteins are active repressors, and their stability and activity are modulated by auxin. Plant Cell 13(12):2809-22 PUBMEDID:11752389

Specific references

Reed, JW. 2001. Roles and activities of Aux/IAA proteins in Arabidopsis. Trends Plant Sci. 6(9):420-5 PUBMEDID:11544131
Remington, DL; Vision, TJ; Guilfoyle, TJ; Reed, JW. 2004. Contrasting modes of diversification in the Aux/IAA and ARF gene families. Plant Physiol. 135(3):1738-52 PUBMEDID:15247399