Plant Transcription factor database - Universität Potsdam
version: 3.0

Sorghum bicolor AUX/IAA Family


Tiwari et al. 2004: Aux/IAA proteins are short-lived nuclear proteins that repress expression of primary/early auxin response genes in protoplast transfection assays. Repression is thought to result from Aux/IAA proteins dimerizing with auxin response factor (ARF) transcriptional activators that reside on auxin-responsive promoter elements, referred to as AuxREs. Most Aux/IAA proteins contain four conserved domains, designated domains I, II, III, and IV. Domain II and domains III and IV play roles in protein stability and dimerization, respectively. A clear function for domain I had not been established. Results reported here indicate that domain I in Aux/IAA proteins is an active repression domain that is transferable and dominant over activation domains. An LxLxL motif within domain I is important for conferring repression. The dominance of Aux/IAA repression domains over activation domains in ARF transcriptional activators provides a plausible explanation for the repression of auxin response genes via ARF-Aux/IAA dimerization on auxin-responsive promoters.

Members of this family
  SHOULD possess AUX_IAA domain
  SHOULD NOT possess Auxin_resp B3 domains

Domain alignments

Benchmark against A. thaliana

The Sensitivity and Positive Predictive Value (PPV) were assessed for this family. The data reported by Remington et al. 2004 for A. thaliana were taken as gold standard.

The gold standard reported 29 members for this family, 28 of which are present in ArabTFDB, giving a PPV of 1.00. One additional member not present in ArabTFDB might be a false negative, giving a Sensitivity of 0.97.

This family is also present in:


There are 26 gene models in this family

Gene modelDescriptionDomains
143472 estExt_fgenesh1_pm.C_chr_30905 AUX_IAA
147168 estExt_fgenesh1_kg.C_chr_10145 AUX_IAA
149651 estExt_fgenesh1_kg.C_chr_90092 AUX_IAA
4134231 gw1.10.14722.1 AUX_IAA
4766356 estExt_Genewise1.C_chr_86202 AUX_IAA
4804820 e_gw1.3.1622.1 AUX_IAA
4815235 e_gw1.4.2621.1 AUX_IAA
4877472 estExt_Genewise1Plus.C_chr_30658 AUX_IAA
4980419 fgenesh1_pg.C_chr_4003252 AUX_IAA
4981682 fgenesh1_pg.C_chr_5001042 AUX_IAA
4986005 fgenesh1_pg.C_chr_7000095 AUX_IAA
4992309 fgenesh1_pg.C_chr_9002037 AUX_IAA
4996481 estExt_fgenesh1_pg.C_chr_10511 AUX_IAA
5002538 estExt_fgenesh1_pg.C_chr_32852 AUX_IAA
5009369 estExt_fgenesh1_pg.C_chr_90638 AUX_IAA
5034180 Sb02g030700 AUX_IAA
5035613 Sb03g011680 AUX_IAA
5048505 Sb01g014120 AUX_IAA
5048506 Sb01g014130 AUX_IAA
5050654 Sb02g004670 AUX_IAA
5056134 Sb04g037260 AUX_IAA
5059769 Sb08g020580 AUX_IAA
5060198 Sb09g005430 AUX_IAA
5060945 Sb09g028210 AUX_IAA
5061355 Sb10g004590 AUX_IAA
5061737 Sb10g019590 AUX_IAA

General references

Liscum, E; Reed, JW. 2002. Genetics of Aux/IAA and ARF action in plant growth and development. Plant Mol. Biol. 49(3-4):387-400 PUBMEDID:12036262
Tiwari, SB; Hagen, G; Guilfoyle, TJ. 2004. Aux/IAA proteins contain a potent transcriptional repression domain. Plant Cell 16(2):533-43 PUBMEDID:14742873
Tiwari, SB; Wang, XJ; Hagen, G; Guilfoyle, TJ. 2001. AUX/IAA proteins are active repressors, and their stability and activity are modulated by auxin. Plant Cell 13(12):2809-22 PUBMEDID:11752389