Plant Transcription factor database - Universität Potsdam
version: 3.0

Arabidopsis lyrata BES1 Family


Yin et al. 2005: Brassinosteroids (BRs) signal through a plasma membrane-localized receptor kinase to regulate plant growth and development. We showed previously that a novel protein, BES1, accumulates in the nucleus in response to BRs, where it plays a role in BR-regulated gene expression; however, the mechanism by which BES1 regulates gene expression is unknown. In this study, we dissect BES1 subdomains and establish that BES1 is a transcription factor that binds to and activates BR target gene promoters both in vitro and in vivo. BES1 interacts with a basic helix-loop-helix protein, BIM1, to synergistically bind to E box (CANNTG) sequences present in many BR-induced promoters. Loss-of-function and gain-of-function mutants of BIM1 and its close family members display BR response phenotypes. Thus, BES1 defines a new class of plant-specific transcription factors that cooperate with transcription factors such as BIM1 to regulate BR-induced genes.

Members of this family
  SHOULD possess DUF822 domain

Domain alignments

This family is also present in:


There are 9 gene models in this family

Gene modelDescriptionDomains
346398 fgenesh1_pg.C_scaffold_4002740 DUF822 Glyco_hydro_14
356484 fgenesh1_pg.C_scaffold_8000271 DUF822 Glyco_hydro_14
472158 fgenesh2_kg.1__2112__AT1G19350.4 DUF822
476647 fgenesh2_kg.2__1777__AT1G75080.2 DUF822
485421 fgenesh2_kg.5__1413__AT3G50750.1 DUF822
492971 fgenesh2_kg.7__2404__AT4G18890.1 DUF822
856241 Al_scaffold_0371_3 DUF822
895772 scaffold_202846.1 DUF822
912686 scaffold_700428.1 DUF822

General references

Li, L; Deng, XW. 2005. It runs in the family: regulation of brassinosteroid signaling by the BZR1-BES1 class of transcription factors. Trends Plant Sci. 10(6):266-8 PUBMEDID:15949759
Vert, G; Nemhauser, JL; Geldner, N; Hong, F; Chory, J. 2005. Molecular mechanisms of steroid hormone signaling in plants. Annu. Rev. Cell Dev. Biol. 21:177-201 PUBMEDID:16212492
Yin, Y; Vafeados, D; Tao, Y; Yoshida, S; Asami, T; Chory, J. 2005. A new class of transcription factors mediates brassinosteroid-regulated gene expression in Arabidopsis. Cell 120(2):249-59 PUBMEDID:15680330