Plant Transcription factor database - Universität Potsdam
version: 3.0

Arabidopsis lyrata C2C2-Dof Family


Yanagisawa. 2004: Dof (DNA-binding with one finger) domain proteins are plant-specific transcription factors with a highly conserved DNA-binding domain, which presumably includes a single C(2)-C(2) zinc finger. During the past decade, numerous Dof domain proteins have been identified in both monocots and dicots including maize, barley, wheat, rice, tobacco, Arabidopsis, pumpkin, potato, and pea. Biochemical, molecular biological and molecular genetic analyses revealed that Dof domain proteins function as a transcriptional activator or a repressor involved in diverse plant-specific biological processes. Although more physiological roles of Dof domain proteins would be elucidated in future because of numerous Dof domain proteins in plants, it is already evident that the Dof domain proteins play critical roles as transcriptional regulators in plant growth and development.

Members of this family
  SHOULD possess zf-Dof domain

Domain alignments

Benchmark against A. thaliana

The Sensitivity and Positive Predictive Value (PPV) were assessed for this family. The data reported by Lijavetzky et al. 2003 for A. thaliana were taken as gold standard.

The gold standard reported 36 members for this family, 35 of which are present in ArabTFDB, giving a PPV of 0.97. One additional member not present in ArabTFDB might be a false negative, giving a Sensitivity of 0.97.

This family is also present in:


There are 34 gene models in this family

Gene modelDescriptionDomains
313311 fgenesh1_pm.C_scaffold_1002091 zf-Dof
327681 fgenesh1_pm.C_scaffold_6002901 zf-Dof
473042 fgenesh2_kg.1__2996__AT1G28310.2 zf-Dof
473910 fgenesh2_kg.1__3864__AT1G47655.1 zf-Dof
474287 fgenesh2_kg.1__4241__AT1G51700.1 zf-Dof
474883 fgenesh2_kg.2__13__AT1G64620.1 zf-Dof
476091 fgenesh2_kg.2__1221__AT1G69570.1 zf-Dof
481761 fgenesh2_kg.4__821__AT2G28510.1 zf-Dof
481796 fgenesh2_kg.4__856__AT2G28810.1 zf-Dof
484945 fgenesh2_kg.5__937__AT3G45610.1 zf-Dof
485960 fgenesh2_kg.5__1952__AT3G55370.2 zf-Dof
486687 fgenesh2_kg.5__2679__AT3G61850.1 zf-Dof
487022 fgenesh2_kg.6__156__AT5G02460.1 zf-Dof
490815 fgenesh2_kg.7__248__AT4G38000.1 zf-Dof
492780 fgenesh2_kg.7__2213__AT4G21080.1 zf-Dof
496158 fgenesh2_kg.8__1974__AT5G60200.1 zf-Dof
496791 fgenesh2_kg.8__2607__AT5G65590.1 zf-Dof
858243 Al_scaffold_0007_1742 zf-Dof
866082 Al_scaffold_0005_1561 zf-Dof
878939 Al_scaffold_0001_706 zf-Dof
889592 scaffold_102386.1 zf-Dof
890435 scaffold_103229.1 zf-Dof
898570 scaffold_302540.1 zf-Dof
902497 scaffold_401998.1 zf-Dof
902903 scaffold_402404.1 zf-Dof
904128 scaffold_403629.1 zf-Dof
906610 scaffold_502314.1 zf-Dof
914578 scaffold_702320.1 zf-Dof
914579 scaffold_702321.1 zf-Dof
916337 scaffold_704079.1 zf-Dof
919324 scaffold_802724.1 zf-Dof
919507 scaffold_802907.1 zf-Dof
919576 scaffold_802976.1 zf-Dof
920022 scaffold_803422.1 zf-Dof

General references

Moreno-Risueno, MA; Martínez, M; Vicente-Carbajosa, J; Carbonero, P. 2006. The family of DOF transcription factors: from green unicellular algae to vascular plants. Mol Genet Genomics PUBMEDID:17180359
Shigyo, M; Tabei, N; Yoneyama, T; Yanagisawa, S. 2006. Evolutional processes during the formation of the plant-specific Dof transcription factor family. Plant Cell Physiol PUBMEDID:17132629
Umemura, Y; Ishiduka, T; Yamamoto, R; Esaka, M. 2004. The Dof domain, a zinc finger DNA-binding domain conserved only in higher plants, truly functions as a Cys2/Cys2 Zn finger domain. Plant J. 37(5):741-9 PUBMEDID:14871313
Yanagisawa, S. 1997. Dof DNA-binding domains of plant transcription factors contribute to multiple protein-protein interactions. Eur. J. Biochem. 250(2):403-10 PUBMEDID:9428691
Yanagisawa, S. 2002. The Dof family of plant transcription factors. Trends Plant Sci. 7(12):555-60 PUBMEDID:12475498
Yanagisawa, S. 2004. Dof domain proteins: plant-specific transcription factors associated with diverse phenomena unique to plants. Plant Cell Physiol. 45(4):386-91 PUBMEDID:15111712
Yanagisawa, S; Schmidt, RJ. 1999. Diversity and similarity among recognition sequences of Dof transcription factors. Plant J. 17(2):209-14 PUBMEDID:10074718