Plant Transcription factor database - Universität Potsdam
version: 3.0

Oryza sativa subsp. indica C2C2-Dof Family


Yanagisawa. 2004: Dof (DNA-binding with one finger) domain proteins are plant-specific transcription factors with a highly conserved DNA-binding domain, which presumably includes a single C(2)-C(2) zinc finger. During the past decade, numerous Dof domain proteins have been identified in both monocots and dicots including maize, barley, wheat, rice, tobacco, Arabidopsis, pumpkin, potato, and pea. Biochemical, molecular biological and molecular genetic analyses revealed that Dof domain proteins function as a transcriptional activator or a repressor involved in diverse plant-specific biological processes. Although more physiological roles of Dof domain proteins would be elucidated in future because of numerous Dof domain proteins in plants, it is already evident that the Dof domain proteins play critical roles as transcriptional regulators in plant growth and development.

Members of this family
  SHOULD possess zf-Dof domain

Domain alignments

Benchmark against A. thaliana

The Sensitivity and Positive Predictive Value (PPV) were assessed for this family. The data reported by Lijavetzky et al. 2003 for A. thaliana were taken as gold standard.

The gold standard reported 36 members for this family, 35 of which are present in ArabTFDB, giving a PPV of 0.97. One additional member not present in ArabTFDB might be a false negative, giving a Sensitivity of 0.97.

This family is also present in:


There are 28 gene models in this family

Gene modelDescriptionDomains
OsIBCD001074 Chr01_1570,1656,,,1,1656, zf-Dof
OsIBCD001161 Chr01_1700,1476,,,1,1476, zf-Dof
OsIBCD005722 Chr02_1464,978,,,1,978, zf-Dof
OsIBCD007830 Chr02_4930,924,,,1,924, zf-Dof
OsIBCD009003 Chr03_663,1017,,,1,1017, zf-Dof
OsIBCD009642 Chr03_1562,1203,,,1,1203, zf-Dof
OsIBCD010967 Chr03_3764,1080,,,1,1080, zf-Dof
OsIBCD011199 Chr03_4192,633,,,1,633, zf-Dof
OsIBCD012444 Chr03_6006,1191,,,1,1191, zf-Dof
OsIBCD016020 Chr04_5181,621,,,1,621, zf-Dof
OsIBCD016217 Chr05_108,1374,,,1,1374, zf-Dof
OsIBCD023581 Chr07_2618,906,,,1,906, zf-Dof
OsIBCD024636 Chr07_4180,1431,,,1,1431, zf-Dof
OsIBCD030524 Chr10_1862,1485,,,1,1485, zf-Dof
OsIBCD035526 Chr12_2941,537,,,1,537, zf-Dof
OsIBCD036003 Chr01_909,645,,,1,645, zf-Dof
OsIBCD036857 Chr01_5215,615,,,1,615, zf-Dof
OsIBCD037075 Chr01_6143,963,,,1,963, zf-Dof
OsIBCD038130 Chr02_4488,1092,,,1,1092, zf-Dof
OsIBCD038179 Chr02_4764,864,,,1,864, zf-Dof
OsIBCD039459 Chr03_5504,1050,,,1,1050, zf-Dof
OsIBCD040400 Chr04_4155,1083,,,1,1083, zf-Dof
OsIBCD041244 Chr05_3430,960,,,1,960, zf-Dof
OsIBCD044075 Chr08_3826,1026,,,1,1026, zf-Dof
OsIBCD044701 Chr09_2518,696,,,1,696, zf-Dof
OsIBCD045435 Chr10_2711,822,,,1,822, zf-Dof
OsIBCD045436 Chr10_2721,822,,,1,822, zf-Dof
OsIBSD048796 Supscaffold140_7,960,,,1,960, zf-Dof

General references

Moreno-Risueno, MA; Martínez, M; Vicente-Carbajosa, J; Carbonero, P. 2006. The family of DOF transcription factors: from green unicellular algae to vascular plants. Mol Genet Genomics PUBMEDID:17180359
Shigyo, M; Tabei, N; Yoneyama, T; Yanagisawa, S. 2006. Evolutional processes during the formation of the plant-specific Dof transcription factor family. Plant Cell Physiol PUBMEDID:17132629
Umemura, Y; Ishiduka, T; Yamamoto, R; Esaka, M. 2004. The Dof domain, a zinc finger DNA-binding domain conserved only in higher plants, truly functions as a Cys2/Cys2 Zn finger domain. Plant J. 37(5):741-9 PUBMEDID:14871313
Yanagisawa, S. 1997. Dof DNA-binding domains of plant transcription factors contribute to multiple protein-protein interactions. Eur. J. Biochem. 250(2):403-10 PUBMEDID:9428691
Yanagisawa, S. 2002. The Dof family of plant transcription factors. Trends Plant Sci. 7(12):555-60 PUBMEDID:12475498
Yanagisawa, S. 2004. Dof domain proteins: plant-specific transcription factors associated with diverse phenomena unique to plants. Plant Cell Physiol. 45(4):386-91 PUBMEDID:15111712
Yanagisawa, S; Schmidt, RJ. 1999. Diversity and similarity among recognition sequences of Dof transcription factors. Plant J. 17(2):209-14 PUBMEDID:10074718