Plant Transcription factor database - Universität Potsdam
version: 3.0

Physcomitrella patens C2C2-Dof Family


Yanagisawa. 2004: Dof (DNA-binding with one finger) domain proteins are plant-specific transcription factors with a highly conserved DNA-binding domain, which presumably includes a single C(2)-C(2) zinc finger. During the past decade, numerous Dof domain proteins have been identified in both monocots and dicots including maize, barley, wheat, rice, tobacco, Arabidopsis, pumpkin, potato, and pea. Biochemical, molecular biological and molecular genetic analyses revealed that Dof domain proteins function as a transcriptional activator or a repressor involved in diverse plant-specific biological processes. Although more physiological roles of Dof domain proteins would be elucidated in future because of numerous Dof domain proteins in plants, it is already evident that the Dof domain proteins play critical roles as transcriptional regulators in plant growth and development.

Members of this family
  SHOULD possess zf-Dof domain

Domain alignments

Benchmark against A. thaliana

The Sensitivity and Positive Predictive Value (PPV) were assessed for this family. The data reported by Lijavetzky et al. 2003 for A. thaliana were taken as gold standard.

The gold standard reported 36 members for this family, 35 of which are present in ArabTFDB, giving a PPV of 0.97. One additional member not present in ArabTFDB might be a false negative, giving a Sensitivity of 0.97.

This family is also present in:


There are 20 gene models in this family

Gene modelDescriptionDomains
135214 e_gw1.118.115.1 zf-Dof
138651 e_gw1.149.93.1 zf-Dof
140773 e_gw1.170.52.1 zf-Dof
153324 e_gw1.392.16.1 zf-Dof
160509 estExt_fgenesh1_pg.C_220220 zf-Dof
161886 estExt_fgenesh1_pg.C_370003 zf-Dof
166789 estExt_fgenesh1_pg.C_1240078 zf-Dof
169169 estExt_fgenesh1_pg.C_1990054 zf-Dof
36704 gw1.341.75.1 zf-Dof
38753 gw1.12.257.1 zf-Dof
38754 gw1.177.85.1 zf-Dof
38756 gw1.68.219.1 zf-Dof
38760 gw1.69.138.1 zf-Dof
38768 gw1.351.53.1 zf-Dof
38836 gw1.26.178.1 zf-Dof
38837 gw1.385.26.1 zf-Dof
38838 gw1.1.449.1 zf-Dof
38844 gw1.267.48.1 zf-Dof
69364 fgenesh1_pg.scaffold_22000226 zf-Dof
88451 fgenesh1_pg.scaffold_169000096 zf-Dof

General references

Moreno-Risueno, MA; Martínez, M; Vicente-Carbajosa, J; Carbonero, P. 2006. The family of DOF transcription factors: from green unicellular algae to vascular plants. Mol Genet Genomics PUBMEDID:17180359
Shigyo, M; Tabei, N; Yoneyama, T; Yanagisawa, S. 2006. Evolutional processes during the formation of the plant-specific Dof transcription factor family. Plant Cell Physiol PUBMEDID:17132629
Umemura, Y; Ishiduka, T; Yamamoto, R; Esaka, M. 2004. The Dof domain, a zinc finger DNA-binding domain conserved only in higher plants, truly functions as a Cys2/Cys2 Zn finger domain. Plant J. 37(5):741-9 PUBMEDID:14871313
Yanagisawa, S. 1997. Dof DNA-binding domains of plant transcription factors contribute to multiple protein-protein interactions. Eur. J. Biochem. 250(2):403-10 PUBMEDID:9428691
Yanagisawa, S. 2002. The Dof family of plant transcription factors. Trends Plant Sci. 7(12):555-60 PUBMEDID:12475498
Yanagisawa, S. 2004. Dof domain proteins: plant-specific transcription factors associated with diverse phenomena unique to plants. Plant Cell Physiol. 45(4):386-91 PUBMEDID:15111712
Yanagisawa, S; Schmidt, RJ. 1999. Diversity and similarity among recognition sequences of Dof transcription factors. Plant J. 17(2):209-14 PUBMEDID:10074718