Plant Transcription factor database - Universität Potsdam
version: 3.0

Populus trichocarpa C2C2-Dof Family


Yanagisawa. 2004: Dof (DNA-binding with one finger) domain proteins are plant-specific transcription factors with a highly conserved DNA-binding domain, which presumably includes a single C(2)-C(2) zinc finger. During the past decade, numerous Dof domain proteins have been identified in both monocots and dicots including maize, barley, wheat, rice, tobacco, Arabidopsis, pumpkin, potato, and pea. Biochemical, molecular biological and molecular genetic analyses revealed that Dof domain proteins function as a transcriptional activator or a repressor involved in diverse plant-specific biological processes. Although more physiological roles of Dof domain proteins would be elucidated in future because of numerous Dof domain proteins in plants, it is already evident that the Dof domain proteins play critical roles as transcriptional regulators in plant growth and development.

Members of this family
  SHOULD possess zf-Dof domain

Domain alignments

Benchmark against A. thaliana

The Sensitivity and Positive Predictive Value (PPV) were assessed for this family. The data reported by Lijavetzky et al. 2003 for A. thaliana were taken as gold standard.

The gold standard reported 36 members for this family, 35 of which are present in ArabTFDB, giving a PPV of 0.97. One additional member not present in ArabTFDB might be a false negative, giving a Sensitivity of 0.97.

This family is also present in:


There are 41 gene models in this family

Gene modelDescriptionDomains
197655 gw1.IV.2744.1 zf-Dof
197955 gw1.IV.3044.1 zf-Dof
204826 gw1.V.227.1 zf-Dof
208453 gw1.V.3854.1 zf-Dof
209054 gw1.V.4455.1 zf-Dof
218804 gw1.VII.3109.1 zf-Dof
235344 gw1.XI.3324.1 zf-Dof
248810 gw1.XIX.1210.1 zf-Dof
251224 gw1.XV.660.1 zf-Dof
252092 gw1.XV.1528.1 zf-Dof
256257 gw1.XVI.2196.1 zf-Dof
266521 gw1.124.171.1 zf-Dof
266529 gw1.124.179.1 zf-Dof
280855 gw1.261.5.1 zf-Dof
286802 gw1.40.562.1 zf-Dof
411129 gw1.II.2464.1 zf-Dof
412541 gw1.II.3876.1 zf-Dof
417469 gw1.VI.1842.1 zf-Dof
422049 gw1.XII.509.1 zf-Dof
422589 gw1.XII.1049.1 zf-Dof
422632 gw1.XII.1092.1 zf-Dof
556324 eugene3.00041037 zf-Dof
563045 eugene3.00070983 zf-Dof
571281 eugene3.00130645 zf-Dof
577658 eugene3.00170400 zf-Dof
646238 grail3.0089006501 zf-Dof
647744 grail3.0093009501 zf-Dof
660390 grail3.0091000801 zf-Dof
664142 grail3.0035031801 zf-Dof
678455 grail3.0044005601 zf-Dof
712091 estExt_Genewise1_v1.C_LG_III1128 zf-Dof
752171 fgenesh4_pg.C_LG_I001774 zf-Dof
755421 fgenesh4_pg.C_LG_II001601 zf-Dof
760414 fgenesh4_pg.C_LG_V000466 zf-Dof
762341 fgenesh4_pg.C_LG_VI000651 zf-Dof
797285 fgenesh4_pm.C_LG_I000288 zf-Dof
803398 fgenesh4_pm.C_LG_VIII000353 zf-Dof
805345 fgenesh4_pm.C_LG_X000651 zf-Dof
820338 estExt_fgenesh4_pg.C_LG_VIII0451 zf-Dof
821560 estExt_fgenesh4_pg.C_LG_IX1263 zf-Dof
824514 estExt_fgenesh4_pg.C_LG_XV0093 zf-Dof

General references

Moreno-Risueno, MA; Martínez, M; Vicente-Carbajosa, J; Carbonero, P. 2006. The family of DOF transcription factors: from green unicellular algae to vascular plants. Mol Genet Genomics PUBMEDID:17180359
Shigyo, M; Tabei, N; Yoneyama, T; Yanagisawa, S. 2006. Evolutional processes during the formation of the plant-specific Dof transcription factor family. Plant Cell Physiol PUBMEDID:17132629
Umemura, Y; Ishiduka, T; Yamamoto, R; Esaka, M. 2004. The Dof domain, a zinc finger DNA-binding domain conserved only in higher plants, truly functions as a Cys2/Cys2 Zn finger domain. Plant J. 37(5):741-9 PUBMEDID:14871313
Yanagisawa, S. 1997. Dof DNA-binding domains of plant transcription factors contribute to multiple protein-protein interactions. Eur. J. Biochem. 250(2):403-10 PUBMEDID:9428691
Yanagisawa, S. 2002. The Dof family of plant transcription factors. Trends Plant Sci. 7(12):555-60 PUBMEDID:12475498
Yanagisawa, S. 2004. Dof domain proteins: plant-specific transcription factors associated with diverse phenomena unique to plants. Plant Cell Physiol. 45(4):386-91 PUBMEDID:15111712
Yanagisawa, S; Schmidt, RJ. 1999. Diversity and similarity among recognition sequences of Dof transcription factors. Plant J. 17(2):209-14 PUBMEDID:10074718