Plant Transcription factor database - Universität Potsdam
version: 3.0

Sorghum bicolor C2C2-Dof Family


Yanagisawa. 2004: Dof (DNA-binding with one finger) domain proteins are plant-specific transcription factors with a highly conserved DNA-binding domain, which presumably includes a single C(2)-C(2) zinc finger. During the past decade, numerous Dof domain proteins have been identified in both monocots and dicots including maize, barley, wheat, rice, tobacco, Arabidopsis, pumpkin, potato, and pea. Biochemical, molecular biological and molecular genetic analyses revealed that Dof domain proteins function as a transcriptional activator or a repressor involved in diverse plant-specific biological processes. Although more physiological roles of Dof domain proteins would be elucidated in future because of numerous Dof domain proteins in plants, it is already evident that the Dof domain proteins play critical roles as transcriptional regulators in plant growth and development.

Members of this family
  SHOULD possess zf-Dof domain

Domain alignments

Benchmark against A. thaliana

The Sensitivity and Positive Predictive Value (PPV) were assessed for this family. The data reported by Lijavetzky et al. 2003 for A. thaliana were taken as gold standard.

The gold standard reported 36 members for this family, 35 of which are present in ArabTFDB, giving a PPV of 0.97. One additional member not present in ArabTFDB might be a false negative, giving a Sensitivity of 0.97.

This family is also present in:


There are 30 gene models in this family

Gene modelDescriptionDomains
127536 fgenesh1_pm.C_chr_4000839 zf-Dof
149733 estExt_fgenesh1_kg.C_chr_90178 zf-Dof
3990925 gw1.9.601.1 zf-Dof
3993350 gw1.3.738.1 zf-Dof
4024447 gw1.1.3761.1 zf-Dof
4034423 gw1.1.4652.1 zf-Dof
4144302 gw1.9.16085.1 zf-Dof
4154232 gw1.4.16660.1 zf-Dof
4164227 gw1.2.19427.1 zf-Dof
4164290 gw1.3.19728.1 zf-Dof
4745683 estExt_Genewise1.C_chr_111348 zf-Dof
4765073 estExt_Genewise1.C_chr_78048 zf-Dof
4817676 e_gw1.5.620.1 zf-Dof
4846609 e_gw1.8.14778.1 zf-Dof
4874905 estExt_Genewise1Plus.C_chr_27883 zf-Dof
4888693 estExt_Genewise1Plus.C_chr_67013 zf-Dof
4963725 fgenesh1_pg.C_chr_1000327 zf-Dof
4975387 fgenesh1_pg.C_chr_3002502 zf-Dof
4996614 estExt_fgenesh1_pg.C_chr_10724 zf-Dof
4997291 estExt_fgenesh1_pg.C_chr_11915 zf-Dof
4998372 estExt_fgenesh1_pg.C_chr_14059 zf-Dof
5002942 estExt_fgenesh1_pg.C_chr_33533 zf-Dof
5004731 estExt_fgenesh1_pg.C_chr_42746 zf-Dof
5007203 estExt_fgenesh1_pg.C_chr_62629 zf-Dof
5008296 estExt_fgenesh1_pg.C_chr_80014 zf-Dof
5008826 estExt_fgenesh1_pg.C_chr_81470 zf-Dof
5035532 Sb03g010280 zf-Dof
5035572 Sb03g011160 zf-Dof
5048880 Sb01g022330 zf-Dof
5052273 Sb02g043310 zf-Dof

General references

Moreno-Risueno, MA; Martínez, M; Vicente-Carbajosa, J; Carbonero, P. 2006. The family of DOF transcription factors: from green unicellular algae to vascular plants. Mol Genet Genomics PUBMEDID:17180359
Shigyo, M; Tabei, N; Yoneyama, T; Yanagisawa, S. 2006. Evolutional processes during the formation of the plant-specific Dof transcription factor family. Plant Cell Physiol PUBMEDID:17132629
Umemura, Y; Ishiduka, T; Yamamoto, R; Esaka, M. 2004. The Dof domain, a zinc finger DNA-binding domain conserved only in higher plants, truly functions as a Cys2/Cys2 Zn finger domain. Plant J. 37(5):741-9 PUBMEDID:14871313
Yanagisawa, S. 1997. Dof DNA-binding domains of plant transcription factors contribute to multiple protein-protein interactions. Eur. J. Biochem. 250(2):403-10 PUBMEDID:9428691
Yanagisawa, S. 2002. The Dof family of plant transcription factors. Trends Plant Sci. 7(12):555-60 PUBMEDID:12475498
Yanagisawa, S. 2004. Dof domain proteins: plant-specific transcription factors associated with diverse phenomena unique to plants. Plant Cell Physiol. 45(4):386-91 PUBMEDID:15111712
Yanagisawa, S; Schmidt, RJ. 1999. Diversity and similarity among recognition sequences of Dof transcription factors. Plant J. 17(2):209-14 PUBMEDID:10074718