Plant Transcription factor database - Universität Potsdam
version: 3.0

Selaginella moellendorffii C2C2-Dof Family


Yanagisawa. 2004: Dof (DNA-binding with one finger) domain proteins are plant-specific transcription factors with a highly conserved DNA-binding domain, which presumably includes a single C(2)-C(2) zinc finger. During the past decade, numerous Dof domain proteins have been identified in both monocots and dicots including maize, barley, wheat, rice, tobacco, Arabidopsis, pumpkin, potato, and pea. Biochemical, molecular biological and molecular genetic analyses revealed that Dof domain proteins function as a transcriptional activator or a repressor involved in diverse plant-specific biological processes. Although more physiological roles of Dof domain proteins would be elucidated in future because of numerous Dof domain proteins in plants, it is already evident that the Dof domain proteins play critical roles as transcriptional regulators in plant growth and development.

Members of this family
  SHOULD possess zf-Dof domain

Domain alignments

Benchmark against A. thaliana

The Sensitivity and Positive Predictive Value (PPV) were assessed for this family. The data reported by Lijavetzky et al. 2003 for A. thaliana were taken as gold standard.

The gold standard reported 36 members for this family, 35 of which are present in ArabTFDB, giving a PPV of 0.97. One additional member not present in ArabTFDB might be a false negative, giving a Sensitivity of 0.97.

This family is also present in:


There are 31 gene models in this family

Gene modelDescriptionDomains
131666 e_gw1.108.44.1 zf-Dof
19630 gw1.28.211.1 zf-Dof
19631 gw1.102.106.1 zf-Dof
19633 gw1.57.182.1 zf-Dof
19636 gw1.111.41.1 zf-Dof
19637 gw1.111.42.1 zf-Dof
19643 gw1.11.354.1 zf-Dof
28959 gw1.41.173.1 zf-Dof
29096 gw1.75.122.1 zf-Dof
29097 gw1.111.65.1 zf-Dof
29563 gw1.6.544.1 zf-Dof
29567 gw1.3.560.1 zf-Dof
29617 gw1.1.713.1 zf-Dof
405079 fgenesh2_pg.C_scaffold_3000302 zf-Dof
405087 fgenesh2_pg.C_scaffold_3000310 PCRF RF-1 zf-Dof
409864 fgenesh2_pg.C_scaffold_11000247 zf-Dof
410014 fgenesh2_pg.C_scaffold_11000397 zf-Dof
414369 fgenesh2_pg.C_scaffold_23000233 zf-Dof
414920 fgenesh2_pg.C_scaffold_25000160 zf-Dof
415191 fgenesh2_pg.C_scaffold_26000121 zf-Dof
416079 fgenesh2_pg.C_scaffold_29000184 zf-Dof
417529 fgenesh2_pg.C_scaffold_35000002 zf-Dof
419294 fgenesh2_pg.C_scaffold_41000203 zf-Dof
419297 fgenesh2_pg.C_scaffold_41000206 zf-Dof
425594 fgenesh2_pg.C_scaffold_75000053 zf-Dof
429122 fgenesh2_pg.C_scaffold_111000008 zf-Dof
429125 fgenesh2_pg.C_scaffold_111000011 zf-Dof
430854 fgenesh2_pg.C_scaffold_139000031 zf-Dof
438474 estExt_fgenesh2_pg.C_30312 zf-Dof
89924 e_gw1.10.335.1 zf-Dof
9042 gw1.139.35.1 zf-Dof

General references

Moreno-Risueno, MA; Martínez, M; Vicente-Carbajosa, J; Carbonero, P. 2006. The family of DOF transcription factors: from green unicellular algae to vascular plants. Mol Genet Genomics PUBMEDID:17180359
Shigyo, M; Tabei, N; Yoneyama, T; Yanagisawa, S. 2006. Evolutional processes during the formation of the plant-specific Dof transcription factor family. Plant Cell Physiol PUBMEDID:17132629
Umemura, Y; Ishiduka, T; Yamamoto, R; Esaka, M. 2004. The Dof domain, a zinc finger DNA-binding domain conserved only in higher plants, truly functions as a Cys2/Cys2 Zn finger domain. Plant J. 37(5):741-9 PUBMEDID:14871313
Yanagisawa, S. 1997. Dof DNA-binding domains of plant transcription factors contribute to multiple protein-protein interactions. Eur. J. Biochem. 250(2):403-10 PUBMEDID:9428691
Yanagisawa, S. 2002. The Dof family of plant transcription factors. Trends Plant Sci. 7(12):555-60 PUBMEDID:12475498
Yanagisawa, S. 2004. Dof domain proteins: plant-specific transcription factors associated with diverse phenomena unique to plants. Plant Cell Physiol. 45(4):386-91 PUBMEDID:15111712
Yanagisawa, S; Schmidt, RJ. 1999. Diversity and similarity among recognition sequences of Dof transcription factors. Plant J. 17(2):209-14 PUBMEDID:10074718