Plant Transcription factor database - Universität Potsdam
version: 3.0

Vitis vinifera C2C2-Dof Family


Yanagisawa. 2004: Dof (DNA-binding with one finger) domain proteins are plant-specific transcription factors with a highly conserved DNA-binding domain, which presumably includes a single C(2)-C(2) zinc finger. During the past decade, numerous Dof domain proteins have been identified in both monocots and dicots including maize, barley, wheat, rice, tobacco, Arabidopsis, pumpkin, potato, and pea. Biochemical, molecular biological and molecular genetic analyses revealed that Dof domain proteins function as a transcriptional activator or a repressor involved in diverse plant-specific biological processes. Although more physiological roles of Dof domain proteins would be elucidated in future because of numerous Dof domain proteins in plants, it is already evident that the Dof domain proteins play critical roles as transcriptional regulators in plant growth and development.

Members of this family
  SHOULD possess zf-Dof domain

Domain alignments

Benchmark against A. thaliana

The Sensitivity and Positive Predictive Value (PPV) were assessed for this family. The data reported by Lijavetzky et al. 2003 for A. thaliana were taken as gold standard.

The gold standard reported 36 members for this family, 35 of which are present in ArabTFDB, giving a PPV of 0.97. One additional member not present in ArabTFDB might be a false negative, giving a Sensitivity of 0.97.

This family is also present in:


There are 26 gene models in this family

Gene modelDescriptionDomains
GSVIVP00003072001 zf-Dof
GSVIVP00003074001 zf-Dof
GSVIVP00003807001 zf-Dof
GSVIVP00003895001 zf-Dof
GSVIVP00004032001 zf-Dof
GSVIVP00004167001 zf-Dof
GSVIVP00006675001 zf-Dof
GSVIVP00008647001 zf-Dof
GSVIVP00010280001 zf-Dof
GSVIVP00011635001 zf-Dof
GSVIVP00014273001 zf-Dof
GSVIVP00014741001 zf-Dof
GSVIVP00016092001 zf-Dof
GSVIVP00016324001 zf-Dof
GSVIVP00017546001 zf-Dof
GSVIVP00018482001 zf-Dof
GSVIVP00020987001 zf-Dof
GSVIVP00021306001 zf-Dof
GSVIVP00024349001 zf-Dof
GSVIVP00024470001 zf-Dof
GSVIVP00034203001 zf-Dof
GSVIVP00035876001 zf-Dof
GSVIVP00036500001 zf-Dof
GSVIVP00036946001 zf-Dof
GSVIVP00037222001 zf-Dof
GSVIVP00038908001 zf-Dof

General references

Moreno-Risueno, MA; Martínez, M; Vicente-Carbajosa, J; Carbonero, P. 2006. The family of DOF transcription factors: from green unicellular algae to vascular plants. Mol Genet Genomics PUBMEDID:17180359
Shigyo, M; Tabei, N; Yoneyama, T; Yanagisawa, S. 2006. Evolutional processes during the formation of the plant-specific Dof transcription factor family. Plant Cell Physiol PUBMEDID:17132629
Umemura, Y; Ishiduka, T; Yamamoto, R; Esaka, M. 2004. The Dof domain, a zinc finger DNA-binding domain conserved only in higher plants, truly functions as a Cys2/Cys2 Zn finger domain. Plant J. 37(5):741-9 PUBMEDID:14871313
Yanagisawa, S. 1997. Dof DNA-binding domains of plant transcription factors contribute to multiple protein-protein interactions. Eur. J. Biochem. 250(2):403-10 PUBMEDID:9428691
Yanagisawa, S. 2002. The Dof family of plant transcription factors. Trends Plant Sci. 7(12):555-60 PUBMEDID:12475498
Yanagisawa, S. 2004. Dof domain proteins: plant-specific transcription factors associated with diverse phenomena unique to plants. Plant Cell Physiol. 45(4):386-91 PUBMEDID:15111712
Yanagisawa, S; Schmidt, RJ. 1999. Diversity and similarity among recognition sequences of Dof transcription factors. Plant J. 17(2):209-14 PUBMEDID:10074718