Plant Transcription factor database - Universität Potsdam
version: 3.0

Zea mays C2C2-Dof Family


Yanagisawa. 2004: Dof (DNA-binding with one finger) domain proteins are plant-specific transcription factors with a highly conserved DNA-binding domain, which presumably includes a single C(2)-C(2) zinc finger. During the past decade, numerous Dof domain proteins have been identified in both monocots and dicots including maize, barley, wheat, rice, tobacco, Arabidopsis, pumpkin, potato, and pea. Biochemical, molecular biological and molecular genetic analyses revealed that Dof domain proteins function as a transcriptional activator or a repressor involved in diverse plant-specific biological processes. Although more physiological roles of Dof domain proteins would be elucidated in future because of numerous Dof domain proteins in plants, it is already evident that the Dof domain proteins play critical roles as transcriptional regulators in plant growth and development.

Members of this family
  SHOULD possess zf-Dof domain

Domain alignments

Benchmark against A. thaliana

The Sensitivity and Positive Predictive Value (PPV) were assessed for this family. The data reported by Lijavetzky et al. 2003 for A. thaliana were taken as gold standard.

The gold standard reported 36 members for this family, 35 of which are present in ArabTFDB, giving a PPV of 0.97. One additional member not present in ArabTFDB might be a false negative, giving a Sensitivity of 0.97.

This family is also present in:


There are 57 gene models in this family

Gene modelDescriptionDomains
AC190482.1_FGP031 zf-Dof
AC194246.3_FGP043 zf-Dof
AC214789.2_FGP025 zf-Dof
AC215860.3_FGP033 zf-Dof
GRMZM2G001066_P01 zf-Dof
GRMZM2G007176_P01 zf-Dof
GRMZM2G007176_P02 zf-Dof
GRMZM2G009406_P01 zf-Dof
GRMZM2G010290_P01 zf-Dof
GRMZM2G011832_P01 zf-Dof
GRMZM2G017470_P01 zf-Dof
GRMZM2G025521_P01 zf-Dof
GRMZM2G027729_P01 zf-Dof
GRMZM2G027973_P01 zf-Dof
GRMZM2G033646_P01 zf-Dof
GRMZM2G042218_P01 zf-Dof
GRMZM2G045678_P01 zf-Dof
GRMZM2G047353_P01 zf-Dof
GRMZM2G047353_P02 zf-Dof
GRMZM2G047353_P03 zf-Dof
GRMZM2G047353_P04 zf-Dof
GRMZM2G061292_P01 zf-Dof
GRMZM2G064655_P01 zf-Dof
GRMZM2G073256_P01 zf-Dof
GRMZM2G081262_P01 zf-Dof
GRMZM2G082490_P01 zf-Dof
GRMZM2G084130_P01 zf-Dof
GRMZM2G089949_P01 zf-Dof
GRMZM2G091907_P01 zf-Dof
GRMZM2G093725_P01 zf-Dof
GRMZM2G108865_P01 zf-Dof
GRMZM2G112458_P01 zf-Dof
GRMZM2G114998_P01 zf-Dof
GRMZM2G123900_P01 zf-Dof
GRMZM2G123900_P02 zf-Dof
GRMZM2G131897_P01 zf-Dof
GRMZM2G134545_P01 zf-Dof
GRMZM2G135703_P01 zf-Dof
GRMZM2G137502_P01 zf-Dof
GRMZM2G138455_P01 zf-Dof
GRMZM2G140694_P01 zf-Dof
GRMZM2G142718_P01 zf-Dof
GRMZM2G144172_P01 zf-Dof
GRMZM2G146283_P01 zf-Dof
GRMZM2G148572_P01 zf-Dof
GRMZM2G153808_P01 zf-Dof
GRMZM2G158309_P01 zf-Dof
GRMZM2G162749_P01 zf-Dof
GRMZM2G162749_P02 zf-Dof
GRMZM2G163207_P01 zf-Dof
GRMZM2G166223_P01 zf-Dof
GRMZM2G171852_P01 zf-Dof
GRMZM2G176063_P01 zf-Dof
GRMZM2G178767_P01 zf-Dof
GRMZM2G179069_P01 zf-Dof
GRMZM2G179184_P01 zf-Dof
GRMZM2G180279_P01 zf-Dof

General references

Moreno-Risueno, MA; Martínez, M; Vicente-Carbajosa, J; Carbonero, P. 2006. The family of DOF transcription factors: from green unicellular algae to vascular plants. Mol Genet Genomics PUBMEDID:17180359
Shigyo, M; Tabei, N; Yoneyama, T; Yanagisawa, S. 2006. Evolutional processes during the formation of the plant-specific Dof transcription factor family. Plant Cell Physiol PUBMEDID:17132629
Umemura, Y; Ishiduka, T; Yamamoto, R; Esaka, M. 2004. The Dof domain, a zinc finger DNA-binding domain conserved only in higher plants, truly functions as a Cys2/Cys2 Zn finger domain. Plant J. 37(5):741-9 PUBMEDID:14871313
Yanagisawa, S. 1997. Dof DNA-binding domains of plant transcription factors contribute to multiple protein-protein interactions. Eur. J. Biochem. 250(2):403-10 PUBMEDID:9428691
Yanagisawa, S. 2002. The Dof family of plant transcription factors. Trends Plant Sci. 7(12):555-60 PUBMEDID:12475498
Yanagisawa, S. 2004. Dof domain proteins: plant-specific transcription factors associated with diverse phenomena unique to plants. Plant Cell Physiol. 45(4):386-91 PUBMEDID:15111712
Yanagisawa, S; Schmidt, RJ. 1999. Diversity and similarity among recognition sequences of Dof transcription factors. Plant J. 17(2):209-14 PUBMEDID:10074718