Plant Transcription factor database - Universität Potsdam
version: 3.0

Arabidopsis lyrata GRF Family


Kim et al. 2003: Previously, we identified a novel rice gene, GROWTH-REGULATING FACTOR1 (OsGRF1), which encodes a putative transcription factor that appears to play a regulatory role in stem elongation. We now describe the GRF gene family of Arabidopsis thaliana (AtGRF), which comprises nine members. The deduced AtGRF proteins contain the same characteristic regions--the QLQ (Gln, Leu, Gln) and WRC (Trp, Arg, Cys) domains--as do OsGRF1 and related proteins in rice, as well as features indicating a function in transcriptional regulation. Most of the AtGRF genes are strongly expressed in actively growing and developing tissues, such as shoot tips, flower buds, and roots, but weakly in mature stem and leaf tissues. Overexpression of AtGRF1 and AtGRF2 resulted in larger leaves and cotyledons, as well as in delayed bolting of the inflorescence stem when compared to wild-type plants. In contrast, triple insertional null mutants of AtGRF1-AtGRF3 had smaller leaves and cotyledons, whereas single mutants displayed no changes in phenotype and double mutants displayed only minor ones. The alteration of leaf growth in overexpressors and triple mutants was based on an increase or decrease in cell size, respectively. These results indicate that AtGRF proteins play a role in the regulation of cell expansion in leaf and cotyledon tissues.

Members of this family
  SHOULD possess QLQ WRC domains

Domain alignments

This family is also present in:


There are 9 gene models in this family

Gene modelDescriptionDomains
322202 fgenesh1_pm.C_scaffold_4002259 GRF QLQ WRC
323835 fgenesh1_pm.C_scaffold_5001379 GRF QLQ UPF0081 WRC
354358 fgenesh1_pg.C_scaffold_7001531 GRF QLQ WRC
478803 fgenesh2_kg.3__1504__AT3G13960.1 GRF QLQ WRC
480218 fgenesh2_kg.3__2919__AT2G06200.1 GRF QLQ WRC
481147 fgenesh2_kg.4__207__AT2G22840.1 GRF QLQ WRC
482616 fgenesh2_kg.4__1676__AT2G36400.1 GRF QLQ WRC
856770 Al_scaffold_0007_269 GRF QLQ WRC
918457 scaffold_801857.1 GRF QLQ WRC

General references

Kim, JH; Choi, D; Kende, H. 2003. The AtGRF family of putative transcription factors is involved in leaf and cotyledon growth in Arabidopsis. Plant J. 36(1):94-104 PUBMEDID:12974814