Plant Transcription factor database - Universität Potsdam
version: 3.0

Oryza sativa subsp. indica GRF Family


Kim et al. 2003: Previously, we identified a novel rice gene, GROWTH-REGULATING FACTOR1 (OsGRF1), which encodes a putative transcription factor that appears to play a regulatory role in stem elongation. We now describe the GRF gene family of Arabidopsis thaliana (AtGRF), which comprises nine members. The deduced AtGRF proteins contain the same characteristic regions--the QLQ (Gln, Leu, Gln) and WRC (Trp, Arg, Cys) domains--as do OsGRF1 and related proteins in rice, as well as features indicating a function in transcriptional regulation. Most of the AtGRF genes are strongly expressed in actively growing and developing tissues, such as shoot tips, flower buds, and roots, but weakly in mature stem and leaf tissues. Overexpression of AtGRF1 and AtGRF2 resulted in larger leaves and cotyledons, as well as in delayed bolting of the inflorescence stem when compared to wild-type plants. In contrast, triple insertional null mutants of AtGRF1-AtGRF3 had smaller leaves and cotyledons, whereas single mutants displayed no changes in phenotype and double mutants displayed only minor ones. The alteration of leaf growth in overexpressors and triple mutants was based on an increase or decrease in cell size, respectively. These results indicate that AtGRF proteins play a role in the regulation of cell expansion in leaf and cotyledon tissues.

Members of this family
  SHOULD possess QLQ WRC domains

Domain alignments

This family is also present in:


There are 13 gene models in this family

Gene modelDescriptionDomains
OsIBCD007558 Chr02_4525,630,,,1,630, QLQ WRC
OsIBCD007674 Chr02_4713,1194,,,1,1194, GRF QLQ WRC
OsIBCD008148 Chr02_5372,1581,,,1,1581, GRF QLQ WRC
OsIBCD011542 Chr03_4719,1254,,,1,1254, GRF QLQ WRC
OsIBCD011543 Chr03_4720,1254,,,1,1254, GRF QLQ WRC
OsIBCD011867 Chr03_5217,2916,,,1,2916, GRF Methyltrans_RNA QLQ WRC
OsIBCD015321 Chr04_4210,738,,,1,738, GRF QLQ WRC
OsIBCD015469 Chr04_4444,1209,,,1,1209, GRF QLQ WRC
OsIBCD019204 Chr06_162,1062,,,1,1062, GRF QLQ WRC
OsIBCD019755 Chr06_993,921,,,1,921, GRF QLQ WRC
OsIBCD023359 Chr07_2274,810,,,1,810, QLQ WRC
OsIBCD033166 Chr11_2636,1146,,,1,1146, GRF QLQ WRC
OsIBCD034967 Chr12_2112,2058,,,1,2058, GRF QLQ WRC hATC

General references

Kim, JH; Choi, D; Kende, H. 2003. The AtGRF family of putative transcription factors is involved in leaf and cotyledon growth in Arabidopsis. Plant J. 36(1):94-104 PUBMEDID:12974814