Plant Transcription factor database - Universität Potsdam
version: 3.0

Physcomitrella patens HRT Family


Raventos et al. 1998: A barley gene encoding a novel DNA-binding protein (HRT) was identified by southwestern screening with baits containing a gibberellin phytohormone response element from an alpha-amylase promoter. The HRT gene contains two introns, the larger of which (5722 base pairs (bp)) contains a 3094-bp LINE-like element with homology to maize Colonist1. In vitro mutagenesis and zinc- and DNA-binding assays demonstrate that HRT contains three unusual zinc fingers with a CX8-9CX10CX2H consensus sequence. HRT is targeted to nuclei, and homologues are expressed in other plants. In vivo, functional tests in plant cells indicate that full-length HRT can repress expression from certain promoters including the Amy1/6-4 and Amy2/32 alpha-amylase promoters. In contrast, truncated forms of HRT containing DNA-binding domains can activate, or derepress, transcription from these promoters. Northern hybridizations indicate that HRT mRNA accumulates to low levels in various tissues. Roles for HRT in mediating developmental and phytohormone-responsive gene expression are discussed.

Members of this family
  SHOULD possess HRT domain

Domain alignments

This family is also present in:


There are 7 gene models in this family

Gene modelDescriptionDomains
163335 estExt_fgenesh1_pg.C_540135 HRT
167396 estExt_fgenesh1_pg.C_1440056 HRT
168719 estExt_fgenesh1_pg.C_1860016 HRT
168816 estExt_fgenesh1_pg.C_1900037 HRT
169277 estExt_fgenesh1_pg.C_2030002 HRT
173392 estExt_fgenesh1_pg.C_4540004 HRT
233972 estExt_fgenesh2_pg.C_1120015 HRT

General references

Raventós, D; Skriver, K; Schlein, M; Karnahl, K; Rogers, SW; Rogers, JC; Mundy, J. 1998. HRT, a novel zinc finger, transcriptional repressor from barley. J. Biol. Chem. 273(36):23313-20 PUBMEDID:9722564