Plant Transcription factor database - Universität Potsdam
version: 3.0

Micromonas pusilla CCMP1545 Jumonji Family


Noh et al. 2004: Flowering in Arabidopsis thaliana is controlled by multiple pathways, including the photoperiod pathway and the FLOWERING LOCUS C (FLC)-dependent pathway. Here, we report that a pair of related jumonji-class transcription factors, EARLY FLOWERING 6 (ELF6) and RELATIVE OF EARLY FLOWERING 6 (REF6), play divergent roles in the regulation of Arabidopsis flowering. ELF6 acts as a repressor in the photoperiod pathway, whereas REF6, which has the highest similarity to ELF6, is an FLC repressor. Ectopic expression studies and expression pattern analyses show that ELF6 and REF6 have different cellular roles and are also regulated differentially despite their sequence similarities. Repression of FLC expression by REF6 accompanies histone modifications in FLC chromatin, indicating that the transcriptional regulatory activity of this class of proteins includes chromatin remodeling. This report demonstrates the in vivo functions of this class of proteins in higher eukaryotes.

Members of this family
  SHOULD possess JmjC JmjN domains
  SHOULD NOT possess Alfin-like ARID zf-C2H2 domains

Domain alignments

This family is also present in:


There are 13 gene models in this family

Gene modelDescriptionDomains
17370 e_gw1.5.262.1 JmjC
18438 e_gw1.7.211.1 JmjC
19881 e_gw1.9.89.1 JmjC JmjN zf-C5HC2
37104 estExt_Genewise1Plus.C_170216 JmjC
4455 gw1.1.477.1 JmjC zf-C5HC2
48230 estExt_fgenesh1_pg.C_100085 JmjC
55194 EuGene.0000020223 JmjC
55195 EuGene.0000020224 JmjN
55793 EuGene.0000020822 JmjC
56632 EuGene.0000030786 JmjC
64527 est_orfs.2_3510_4269971:1 JmjC
66605 est_orfs.17_5588_4274924:1 JmjC
67662 est_orfs.4_6645_4274640:4 JmjC

General references

Balciunas, D; Ronne, H. 2000. Evidence of domain swapping within the jumonji family of transcription factors. Trends Biochem. Sci. 25(6):274-6 PUBMEDID:10838566
Kim, TG; Kraus, JC; Chen, J; Lee, Y. 2003. JUMONJI, a critical factor for cardiac development, functions as a transcriptional repressor. J. Biol. Chem. 278(43):42247-55 PUBMEDID:12890668
Takeuchi, T; Watanabe, Y; Takano-Shimizu, T; Kondo, S. 2006. Roles of jumonji and jumonji family genes in chromatin regulation and development. Dev Dyn PUBMEDID:16715513