Plant Transcription factor database - Universität Potsdam
version: 3.0

Arabidopsis lyrata LOB Family


Husbands et al. 2007: Conserved in a variety of evolutionarily divergent plant species, LOB DOMAIN (LBD) genes define a large, plant-specific family of largely unknown function. LBD genes have been implicated in a variety of developmental processes in plants, although to date, relatively few members have been assigned functions. LBD proteins have previously been predicted to be transcription factors, however supporting evidence has only been circumstantial. To address the biochemical function of LBD proteins, we identified a 6-bp consensus motif recognized by a wide cross-section of LBD proteins, and showed that LATERAL ORGAN BOUNDARIES (LOB), the founding member of the family, is a transcriptional activator in yeast. Thus, the LBD genes encode a novel class of DNA-binding transcription factors. Post-translational regulation of transcription factors is often crucial for control of gene expression. In our study, we demonstrate that members of the basic helix-loop-helix (bHLH) family of transcription factors are capable of interacting with LOB. The expression patterns of bHLH048 and LOB overlap at lateral organ boundaries. Interestingly, the interaction of bHLH048 with LOB results in reduced affinity of LOB for the consensus DNA motif. Thus, our studies suggest that bHLH048 post-translationally regulates the function of LOB at lateral organ boundaries.

Members of this family
  SHOULD possess DUF260 domain

Domain alignments

This family is also present in:


There are 46 gene models in this family

Gene modelDescriptionDomains
311843 fgenesh1_pm.C_scaffold_1000623 DUF260
313993 fgenesh1_pm.C_scaffold_1002773 DUF260
322910 fgenesh1_pm.C_scaffold_5000454 DUF260
327750 fgenesh1_pm.C_scaffold_6002970 DUF260
340538 fgenesh1_pg.C_scaffold_3000301 DUF260
344902 fgenesh1_pg.C_scaffold_4001244 DUF260
346041 fgenesh1_pg.C_scaffold_4002383 DUF260
347883 fgenesh1_pg.C_scaffold_5001275 DUF260
350644 fgenesh1_pg.C_scaffold_6001237 DUF260
475666 fgenesh2_kg.2__796__AT1G65620.2 DUF260
475970 fgenesh2_kg.2__1100__AT1G68510.1 DUF260
476427 fgenesh2_kg.2__1557__AT1G72980.1 DUF260
477490 fgenesh2_kg.3__191__AT3G02550.1 DUF260
478451 fgenesh2_kg.3__1152__AT3G11090.1 DUF260
478788 fgenesh2_kg.3__1489__AT3G13850.1 DUF260
480521 fgenesh2_kg.3__3222__AT2G19510.1 DUF260
481760 fgenesh2_kg.4__820__AT2G28500.1 DUF260
481923 fgenesh2_kg.4__983__AT2G30130.1 DUF260
481945 fgenesh2_kg.4__1005__AT2G30340.1 DUF260
483104 fgenesh2_kg.4__2164__AT2G40470.1 DUF260
483677 fgenesh2_kg.4__2737__AT2G45420.1 DUF260
484553 fgenesh2_kg.5__545__AT3G27650.1 DUF260
486271 fgenesh2_kg.5__2263__AT3G58190.1 DUF260
490546 fgenesh2_kg.6__3680__AT4G00220.1 DUF260
490864 fgenesh2_kg.7__297__AT4G37540.1 DUF260
496854 fgenesh2_kg.8__2670__AT5G67420.1 DUF260
496913 fgenesh2_kg.8__2729__AT5G66870.1 DUF260
861018 Al_scaffold_0006_527 DUF260
865302 Al_scaffold_0005_781 DUF260
866425 Al_scaffold_0005_1904 DUF260
871063 Al_scaffold_0004_3226 DUF260
873692 Al_scaffold_0003_2333 DUF260
876743 Al_scaffold_0002_1337 DUF260
879944 Al_scaffold_0001_1711 DUF260
885142 Al_scaffold_0008_1406 DUF260
887830 scaffold_100624.1 DUF260
890969 scaffold_103763.1 DUF260
890971 scaffold_103765.1 DUF260
900851 scaffold_400352.1 DUF260
903598 scaffold_403099.1 DUF260
903896 scaffold_403397.1 DUF260
904858 scaffold_500562.1 DUF260
905051 scaffold_500755.1 DUF260
906311 scaffold_502015.1 DUF260
914342 scaffold_702084.1 DUF260
919595 scaffold_802995.1 DUF260

General references

Husbands, A; Bell, EM; Shuai, B; Smith, HM; Springer, PS. 2007. LATERAL ORGAN BOUNDARIES defines a new family of DNA-binding transcription factors and can interact with specific bHLH proteins. Nucleic Acids Res. 35(19):6663-71 PUBMEDID:17913740