Plant Transcription factor database - Universität Potsdam
version: 3.0

Arabidopsis thaliana LOB Family

Description

Husbands et al. 2007: Conserved in a variety of evolutionarily divergent plant species, LOB DOMAIN (LBD) genes define a large, plant-specific family of largely unknown function. LBD genes have been implicated in a variety of developmental processes in plants, although to date, relatively few members have been assigned functions. LBD proteins have previously been predicted to be transcription factors, however supporting evidence has only been circumstantial. To address the biochemical function of LBD proteins, we identified a 6-bp consensus motif recognized by a wide cross-section of LBD proteins, and showed that LATERAL ORGAN BOUNDARIES (LOB), the founding member of the family, is a transcriptional activator in yeast. Thus, the LBD genes encode a novel class of DNA-binding transcription factors. Post-translational regulation of transcription factors is often crucial for control of gene expression. In our study, we demonstrate that members of the basic helix-loop-helix (bHLH) family of transcription factors are capable of interacting with LOB. The expression patterns of bHLH048 and LOB overlap at lateral organ boundaries. Interestingly, the interaction of bHLH048 with LOB results in reduced affinity of LOB for the consensus DNA motif. Thus, our studies suggest that bHLH048 post-translationally regulates the function of LOB at lateral organ boundaries.

Members of this family
  SHOULD possess DUF260 domain

Domain alignments

This family is also present in:

References

There are 49 gene models in this family



Gene modelDescriptionDomains
AT1G06280.1 LBD2 (LOB DOMAIN-CONTAINING PROTEIN 2) DUF260
AT1G07900.1 LBD1 (LOB DOMAIN-CONTAINING PROTEIN 1) DUF260
AT1G16530.1 ASL9/LBD3 (LOB DOMAIN-CONTAINING PROTEIN 3) DUF260
AT1G31320.1 LBD4 (LOB DOMAIN-CONTAINING PROTEIN 4) DUF260
AT1G36000.1 LBD5 (LOB DOMAIN-CONTAINING PROTEIN 5) DUF260
AT1G65620.1 AS2 (ASYMMETRIC LEAVES 2) DUF260
AT1G65620.2 AS2 (ASYMMETRIC LEAVES 2) DUF260
AT1G65620.3 AS2 (ASYMMETRIC LEAVES 2) DUF260
AT1G65620.4 AS2 (ASYMMETRIC LEAVES 2) DUF260
AT1G67100.1 LBD40 (LOB DOMAIN-CONTAINING PROTEIN 40) DUF260
AT1G68510.1 LBD42 (LOB DOMAIN-CONTAINING PROTEIN 42) DUF260
AT1G72980.1 LBD7 (LOB DOMAIN-CONTAINING PROTEIN 7) DUF260
AT2G19510.1 LBD8 (LOB DOMAIN-CONTAINING PROTEIN 8) DUF260
AT2G19820.1 LBD9 (LOB DOMAIN-CONTAINING PROTEIN 9) DUF260
AT2G23660.1 LBD10 (LOB DOMAIN-CONTAINING PROTEIN 10) DUF260
AT2G28500.1 LBD11 (LOB DOMAIN-CONTAINING PROTEIN 11) DUF260
AT2G30130.1 ASL5 (phosphoenolpyruvate carboxykinase1) DUF260
AT2G30340.1 LBD13 (LOB DOMAIN-CONTAINING PROTEIN 13) DUF260
AT2G31310.1 LBD14 (LOB DOMAIN-CONTAINING PROTEIN 14) DUF260
AT2G40470.1 LBD15 (LOB DOMAIN-CONTAINING PROTEIN 15) DUF260
AT2G42430.1 LBD16 (ASYMMETRIC LEAVES2-LIKE18) DUF260
AT2G42440.1 LOB domain protein 17 / lateral organ boundaries domain protein 17 (LBD17) DUF260
AT2G45410.1 LBD19 (LOB DOMAIN-CONTAINING PROTEIN 19) DUF260
AT2G45420.1 LBD18 (LOB DOMAIN-CONTAINING PROTEIN 18) DUF260
AT3G02550.1 LBD41 (LOB DOMAIN-CONTAINING PROTEIN 41) DUF260
AT3G03760.1 LBD20 (LOB DOMAIN-CONTAINING PROTEIN 20) DUF260
AT3G11090.1 LBD21 (LOB DOMAIN-CONTAINING PROTEIN 21) DUF260
AT3G13850.1 LBD22 (LOB DOMAIN-CONTAINING PROTEIN 22) DUF260
AT3G26620.1 LBD23 (LOB DOMAIN-CONTAINING PROTEIN 23) DUF260
AT3G26660.1 LBD24 (LOB DOMAIN-CONTAINING PROTEIN 24) DUF260
AT3G27650.1 LBD25 (LOB DOMAIN-CONTAINING PROTEIN 25) DUF260
AT3G27940.1 LBD26 (LOB DOMAIN-CONTAINING PROTEIN 26) DUF260
AT3G47870.1 LBD27 (LOB DOMAIN-CONTAINING PROTEIN 27) DUF260
AT3G49940.1 LBD38 (LOB DOMAIN-CONTAINING PROTEIN 38) DUF260
AT3G50510.1 LBD28 (LOB DOMAIN-CONTAINING PROTEIN 28) DUF260
AT3G58190.1 ASL16/LBD29 (LOB DOMAIN-CONTAINING PROTEIN 29) DUF260
AT4G00210.1 LBD31 (LOB DOMAIN-CONTAINING PROTEIN 31) DUF260
AT4G00220.1 JLO/LBD30 (JAGGED LATERAL ORGANS) DUF260
AT4G22700.1 LBD32 (LOB DOMAIN-CONTAINING PROTEIN 32) DUF260
AT4G37540.1 LBD39 (LOB DOMAIN-CONTAINING PROTEIN 39) DUF260
AT5G06080.1 LBD33 (LOB DOMAIN-CONTAINING PROTEIN 33) DUF260
AT5G15060.1 Identical to Putative LOB domain-containing protein 34 (LBD34) [Arabidopsis Thaliana] (GB:P59469); similar to LBD4 (LOB DOMAIN-CONTAINING PROTEIN 4) [Arabidopsis thaliana] (TAIR:AT1G31320.1); similar to unnamed protein product [Vitis vinifera] (GB:CAO470 DUF260
AT5G35900.1 LBD35 (LOB DOMAIN-CONTAINING PROTEIN 35) DUF260
AT5G63090.1 LOB (LATERAL ORGAN BOUNDARIES) DUF260
AT5G63090.2 LOB (LATERAL ORGAN BOUNDARIES) DUF260
AT5G63090.3 LOB (LATERAL ORGAN BOUNDARIES) DUF260
AT5G63090.4 LOB (LATERAL ORGAN BOUNDARIES) DUF260
AT5G66870.1 ASL1 (LATERAL ORGAN BOUNDARIES domain gene 36) DUF260
AT5G67420.1 LBD37 (LOB DOMAIN-CONTAINING PROTEIN 37) DUF260

General references

Husbands, A; Bell, EM; Shuai, B; Smith, HM; Springer, PS. 2007. LATERAL ORGAN BOUNDARIES defines a new family of DNA-binding transcription factors and can interact with specific bHLH proteins. Nucleic Acids Res. 35(19):6663-71 PUBMEDID:17913740