Plant Transcription factor database - Universität Potsdam
version: 3.0

Carica papaya LOB Family


Husbands et al. 2007: Conserved in a variety of evolutionarily divergent plant species, LOB DOMAIN (LBD) genes define a large, plant-specific family of largely unknown function. LBD genes have been implicated in a variety of developmental processes in plants, although to date, relatively few members have been assigned functions. LBD proteins have previously been predicted to be transcription factors, however supporting evidence has only been circumstantial. To address the biochemical function of LBD proteins, we identified a 6-bp consensus motif recognized by a wide cross-section of LBD proteins, and showed that LATERAL ORGAN BOUNDARIES (LOB), the founding member of the family, is a transcriptional activator in yeast. Thus, the LBD genes encode a novel class of DNA-binding transcription factors. Post-translational regulation of transcription factors is often crucial for control of gene expression. In our study, we demonstrate that members of the basic helix-loop-helix (bHLH) family of transcription factors are capable of interacting with LOB. The expression patterns of bHLH048 and LOB overlap at lateral organ boundaries. Interestingly, the interaction of bHLH048 with LOB results in reduced affinity of LOB for the consensus DNA motif. Thus, our studies suggest that bHLH048 post-translationally regulates the function of LOB at lateral organ boundaries.

Members of this family
  SHOULD possess DUF260 domain

Domain alignments

This family is also present in:


There are 34 gene models in this family

Gene modelDescriptionDomains
evm.TU.supercontig_1.321 DUF260
evm.TU.supercontig_1.325 DUF260
evm.TU.supercontig_1.42 DUF260
evm.TU.supercontig_1.428 DUF260
evm.TU.supercontig_106.61 DUF260
evm.TU.supercontig_108.60 DUF260
evm.TU.supercontig_110.15 DUF260
evm.TU.supercontig_17.167 DUF260
evm.TU.supercontig_18.113 DUF260
evm.TU.supercontig_18.114 DUF260
evm.TU.supercontig_19.133 DUF260
evm.TU.supercontig_19.150 DUF260
evm.TU.supercontig_19.94 DUF260
evm.TU.supercontig_192.6 DUF260
evm.TU.supercontig_2.304 DUF260
evm.TU.supercontig_2.350 DUF260
evm.TU.supercontig_209.3 DUF260
evm.TU.supercontig_21.100 DUF260
evm.TU.supercontig_25.45 DUF260
evm.TU.supercontig_282.15 DUF260
evm.TU.supercontig_3.506 DUF260
evm.TU.supercontig_331.6 DUF260
evm.TU.supercontig_39.98 DUF260
evm.TU.supercontig_50.151 DUF260
evm.TU.supercontig_50.41 DUF260
evm.TU.supercontig_50.42 DUF260
evm.TU.supercontig_53.26 DUF260
evm.TU.supercontig_6.382 DUF260
evm.TU.supercontig_6.385 DUF260
evm.TU.supercontig_6.39 DUF260
evm.TU.supercontig_6.411 DUF260
evm.TU.supercontig_61.24 DUF260
evm.TU.supercontig_61.25 DUF260
evm.TU.supercontig_96.45 DUF260

General references

Husbands, A; Bell, EM; Shuai, B; Smith, HM; Springer, PS. 2007. LATERAL ORGAN BOUNDARIES defines a new family of DNA-binding transcription factors and can interact with specific bHLH proteins. Nucleic Acids Res. 35(19):6663-71 PUBMEDID:17913740