Plant Transcription factor database - Universität Potsdam
version: 3.0

Physcomitrella patens LOB Family

Description

Husbands et al. 2007: Conserved in a variety of evolutionarily divergent plant species, LOB DOMAIN (LBD) genes define a large, plant-specific family of largely unknown function. LBD genes have been implicated in a variety of developmental processes in plants, although to date, relatively few members have been assigned functions. LBD proteins have previously been predicted to be transcription factors, however supporting evidence has only been circumstantial. To address the biochemical function of LBD proteins, we identified a 6-bp consensus motif recognized by a wide cross-section of LBD proteins, and showed that LATERAL ORGAN BOUNDARIES (LOB), the founding member of the family, is a transcriptional activator in yeast. Thus, the LBD genes encode a novel class of DNA-binding transcription factors. Post-translational regulation of transcription factors is often crucial for control of gene expression. In our study, we demonstrate that members of the basic helix-loop-helix (bHLH) family of transcription factors are capable of interacting with LOB. The expression patterns of bHLH048 and LOB overlap at lateral organ boundaries. Interestingly, the interaction of bHLH048 with LOB results in reduced affinity of LOB for the consensus DNA motif. Thus, our studies suggest that bHLH048 post-translationally regulates the function of LOB at lateral organ boundaries.

Members of this family
  SHOULD possess DUF260 domain

Domain alignments

This family is also present in:

References

There are 29 gene models in this family



Gene modelDescriptionDomains
117206 e_gw1.19.226.1 DUF260
128185 e_gw1.69.91.1 DUF260
142497 e_gw1.192.35.1 DUF260
18563 gw1.73.66.1 DUF260
18666 gw1.61.81.1 DUF260
18837 gw1.42.84.1 DUF260
18851 gw1.66.118.1 DUF260
18901 gw1.156.75.1 DUF260
189496 estExt_gwp_gw1.C_1340024 DUF260
19037 gw1.71.84.1 DUF260
19038 gw1.170.36.1 DUF260
19068 gw1.56.82.1 DUF260
193700 estExt_gwp_gw1.C_2030014 DUF260
19474 gw1.170.40.1 DUF260
219930 estExt_Genewise1.C_1840020 DUF260
25219 gw1.35.169.1 DUF260
27306 gw1.10.155.1 DUF260
27685 gw1.7.209.1 DUF260
27856 gw1.12.172.1 DUF260
28882 gw1.9.179.1 DUF260
28883 gw1.13.203.1 DUF260
28884 gw1.9.180.1 DUF260
36649 gw1.9.232.1 DUF260
47789 gw1.41.215.1 DUF260
48199 gw1.167.132.1 DUF260
48669 gw1.157.74.1 DUF260
48750 gw1.190.59.1 DUF260
7278 gw1.261.12.1 DUF260
8381 gw1.238.28.1 DUF260

General references

Husbands, A; Bell, EM; Shuai, B; Smith, HM; Springer, PS. 2007. LATERAL ORGAN BOUNDARIES defines a new family of DNA-binding transcription factors and can interact with specific bHLH proteins. Nucleic Acids Res. 35(19):6663-71 PUBMEDID:17913740