Plant Transcription factor database - Universität Potsdam
version: 3.0

Sorghum bicolor LOB Family

Description

Husbands et al. 2007: Conserved in a variety of evolutionarily divergent plant species, LOB DOMAIN (LBD) genes define a large, plant-specific family of largely unknown function. LBD genes have been implicated in a variety of developmental processes in plants, although to date, relatively few members have been assigned functions. LBD proteins have previously been predicted to be transcription factors, however supporting evidence has only been circumstantial. To address the biochemical function of LBD proteins, we identified a 6-bp consensus motif recognized by a wide cross-section of LBD proteins, and showed that LATERAL ORGAN BOUNDARIES (LOB), the founding member of the family, is a transcriptional activator in yeast. Thus, the LBD genes encode a novel class of DNA-binding transcription factors. Post-translational regulation of transcription factors is often crucial for control of gene expression. In our study, we demonstrate that members of the basic helix-loop-helix (bHLH) family of transcription factors are capable of interacting with LOB. The expression patterns of bHLH048 and LOB overlap at lateral organ boundaries. Interestingly, the interaction of bHLH048 with LOB results in reduced affinity of LOB for the consensus DNA motif. Thus, our studies suggest that bHLH048 post-translationally regulates the function of LOB at lateral organ boundaries.

Members of this family
  SHOULD possess DUF260 domain

Domain alignments

This family is also present in:

References

There are 36 gene models in this family



Gene modelDescriptionDomains
123694 fgenesh1_pm.C_chr_1000748 DUF260
126245 fgenesh1_pm.C_chr_3001276 DUF260
3991913 gw1.5.731.1 DUF260
3992687 gw1.10.759.1 DUF260
4094008 gw1.1.10003.1 DUF260
4103452 gw1.9.11983.1 DUF260
4133891 gw1.9.14975.1 DUF260
4142946 gw1.8.15308.1 DUF260
4143363 gw1.2.15959.1 DUF260
4749625 estExt_Genewise1.C_chr_210115 DUF260
4767295 estExt_Genewise1.C_chr_91177 DUF260
4772788 e_gw1.1.3596.1 DUF260
4803024 e_gw1.3.1576.1 DUF260
4807444 e_gw1.3.20797.1 DUF260
4842544 e_gw1.8.707.1 DUF260
4871303 estExt_Genewise1Plus.C_chr_19886 DUF260
4963986 fgenesh1_pg.C_chr_1000588 DUF260
4968271 fgenesh1_pg.C_chr_1004873 DUF260
4969060 fgenesh1_pg.C_chr_2000376 DUF260
4973672 fgenesh1_pg.C_chr_3000787 DUF260
4987962 fgenesh1_pg.C_chr_7002052 DUF260
4992267 fgenesh1_pg.C_chr_9001995 DUF260
4997101 estExt_fgenesh1_pg.C_chr_11536 DUF260
4997854 estExt_fgenesh1_pg.C_chr_13198 DUF260
5007790 estExt_fgenesh1_pg.C_chr_71255 DUF260
5009963 estExt_fgenesh1_pg.C_chr_91977 DUF260
5010267 estExt_fgenesh1_pg.C_chr_92507 DUF260
5030205 Sb01g041130 DUF260
5030480 Sb01g047000 DUF260
5032255 Sb10g029595 DUF260
5036082 Sb03g025640 DUF260
5036714 Sb03g035920 DUF260
5043938 Sb07g023810 DUF260
5048535 Sb01g014800 DUF260
5056149 Sb04g037550 DUF260
5060018 Sb09g002190 DUF260

General references

Husbands, A; Bell, EM; Shuai, B; Smith, HM; Springer, PS. 2007. LATERAL ORGAN BOUNDARIES defines a new family of DNA-binding transcription factors and can interact with specific bHLH proteins. Nucleic Acids Res. 35(19):6663-71 PUBMEDID:17913740