Plant Transcription factor database - Universität Potsdam
version: 3.0

Selaginella moellendorffii LOB Family

Description

Husbands et al. 2007: Conserved in a variety of evolutionarily divergent plant species, LOB DOMAIN (LBD) genes define a large, plant-specific family of largely unknown function. LBD genes have been implicated in a variety of developmental processes in plants, although to date, relatively few members have been assigned functions. LBD proteins have previously been predicted to be transcription factors, however supporting evidence has only been circumstantial. To address the biochemical function of LBD proteins, we identified a 6-bp consensus motif recognized by a wide cross-section of LBD proteins, and showed that LATERAL ORGAN BOUNDARIES (LOB), the founding member of the family, is a transcriptional activator in yeast. Thus, the LBD genes encode a novel class of DNA-binding transcription factors. Post-translational regulation of transcription factors is often crucial for control of gene expression. In our study, we demonstrate that members of the basic helix-loop-helix (bHLH) family of transcription factors are capable of interacting with LOB. The expression patterns of bHLH048 and LOB overlap at lateral organ boundaries. Interestingly, the interaction of bHLH048 with LOB results in reduced affinity of LOB for the consensus DNA motif. Thus, our studies suggest that bHLH048 post-translationally regulates the function of LOB at lateral organ boundaries.

Members of this family
  SHOULD possess DUF260 domain

Domain alignments

This family is also present in:

References

There are 15 gene models in this family



Gene modelDescriptionDomains
105005 e_gw1.30.245.1 DUF260
111283 e_gw1.42.532.1 DUF260
111494 e_gw1.42.161.1 DUF260
27657 gw1.4.479.1 DUF260
37169 gw1.2.904.1 DUF260
37570 gw1.45.294.1 DUF260
49084 gw1.64.365.1 DUF260
58936 gw1.43.535.1 DUF260
59179 gw1.35.640.1 DUF260
59642 gw1.23.924.1 DUF260
59650 gw1.20.904.1 DUF260
61520 gw1.4.1003.1 DUF260
68988 gw1.14.962.1 DUF260
69267 gw1.2.1589.1 DUF260
69621 gw1.5.1369.1 DUF260

General references

Husbands, A; Bell, EM; Shuai, B; Smith, HM; Springer, PS. 2007. LATERAL ORGAN BOUNDARIES defines a new family of DNA-binding transcription factors and can interact with specific bHLH proteins. Nucleic Acids Res. 35(19):6663-71 PUBMEDID:17913740