Plant Transcription factor database - Universität Potsdam
version: 3.0

Zea mays MED6 Family


Lee et al. 1997: A temperature-sensitive mutation was obtained in Med6p, a component of the mediator complex from the yeast Saccharomyces cerevisiae. The mediator complex has been shown to enable transcriptional activation in vitro. This mutation in Med6p abolished activation of transcription from four of five inducible promoters tested in vivo. There was no effect, however, on uninduced transcription, transcription of constitutively expressed genes, or transcription by RNA polymerases I and III. Mediator-RNA polymerase II complex isolated from the mutant yeast strain was temperature sensitive for transcriptional activation in a reconstituted in vitro system due to a defect in initiation complex formation. A database search revealed the existence of MED6-related genes in humans and Caenorhabditis elegans, suggesting that the role of mediator in transcriptional activation is conserved throughout the evolution.

Members of this family
  SHOULD possess MED6 domain

Domain alignments

This family is also present in:


There are 4 gene models in this family

Gene modelDescriptionDomains
GRMZM2G017537_P01 MED6
GRMZM2G017537_P03 MED6
GRMZM2G114411_P01 MED6
GRMZM2G114411_P02 MED6

General references

Kim, YJ; Björklund, S; Li, Y; Sayre, MH; Kornberg, RD. 1994. A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II. Cell 77(4):599-608 PUBMEDID:8187178
Lee, YC; Min, S; Gim, BS; Kim, YJ. 1997. A transcriptional mediator protein that is required for activation of many RNA polymerase II promoters and is conserved from yeast to humans. Mol. Cell. Biol. 17(8):4622-32 PUBMEDID:9234719