Plant Transcription factor database - Universität Potsdam
version: 3.0

Arabidopsis lyrata MED7 Family

Description

Koschubs et al. 2009: Mediator is a modular multiprotein complex required for regulated transcription by RNA polymerase (Pol) II. Here, we show that the middle module of the Mediator core contains a submodule of unique structure and function that comprises the N-terminal part of subunit Med7 (Med7N) and the highly conserved subunit Med31 (Soh1). The Med7N/31 submodule shows a conserved novel fold, with two proline-rich stretches in Med7N wrapping around the right-handed four-helix bundle of Med31. In vitro, Med7N/31 is required for activated transcription and can act in trans when added exogenously. In vivo, Med7N/31 has a predominantly positive function on the expression of a specific subset of genes, including genes involved in methionine metabolism and iron transport. Comparative phenotyping and transcriptome profiling identify specific and overlapping functions of different Mediator submodules.

Members of this family
  SHOULD possess MED7 domain

Domain alignments

This family is also present in:

References

There are 3 gene models in this family



Gene modelDescriptionDomains
349604 fgenesh1_pg.C_scaffold_6000197 MED7
860747 Al_scaffold_0006_256 MED7
873913 Al_scaffold_0003_2554 MED7

General references

Koschubs, T; Seizl, M; Lariviere, L; Kurth, F; Baumli, S; Martin, DE; Cramer, P. 2009. Identification, structure, and functional requirement of the Mediator submodule Med7N/31. EMBO J. 28(1):69-80 PUBMEDID:19057509