Plant Transcription factor database - Universität Potsdam
version: 3.0

Chlamydomonas reinhardtii MYB Family

Description

Martin & Paz-Ares. 1997: The cloning of the first transcription factor from plants, the C1 gene of maize, indicated that plants use transcription factors that are structurally related to those of animals in their control of gene expression, because C1 showed significant structural homology to the vertebrate cellular proto-oncogene c-MYB. Since 1987, the catalogue of MYB-related transcription factors has increased considerably in size due, primarily, to the ever-expanding number of MYB genes identified in higher plants (Arabidopsis thaliana is estimated to contain more than a hundred MYB genes). In vertebrates, the MYB-related proto-oncogenes comprise a small family with a central role in controlling cellular proliferation and commitment to development. However, while the functions of some plant MYB genes are relatively well understood they are, at present, quite distinct from their animal counterparts.

Members of this family
  SHOULD possess Myb_DNA-binding domain
  SHOULD NOT possess ARID Response_reg SNF2_N domains

Domain alignments

Benchmark against A. thaliana

The Sensitivity and Positive Predictive Value (PPV) were assessed for the families MYB and MYB-related jointly. The data reported by Yanhui et al. 2006 for A. thaliana were taken as gold standard.

The gold standard reported 198 members for this families, 184 of which are present in ArabTFDB, giving a PPV of 0.88. Fourteen additional members not present in ArabTFDB might be false negatives, giving a Sensitivity of 0.93.

This family is also present in:

References

There are 10 gene models in this family



Gene modelDescriptionDomains
103798 e_gwH.23.125.1 Myb_DNA-binding
112237 e_gwW.5.181.1 Myb_DNA-binding
116056 e_gwW.16.94.1 Myb_DNA-binding
117291 e_gwW.19.195.1 Myb_DNA-binding
205725 OVA_Chlre2_kg.scaffold_5000277 Myb_DNA-binding
376761 estExt_fgenesh1_pm.C_chromosome_10729 Myb_DNA-binding
377858 estExt_fgenesh1_pm.C_chromosome_30518 Myb_DNA-binding
395475 pasa_Sanger_mRNA12260 Myb_DNA-binding
401376 pasa_Sanger_mRNA27803 Myb_DNA-binding
409453 pasa_Sanger_mRNA17474 Myb_DNA-binding

General references

Jin, H; Martin, C. 1999. Multifunctionality and diversity within the plant MYB-gene family. Plant Mol. Biol. 41(5):577-85 PUBMEDID:10645718
Klempnauer, KH; Sippel, AE. 1987. The highly conserved amino-terminal region of the protein encoded by the v-myb oncogene functions as a DNA-binding domain. EMBO J. 6(9):2719-25 PUBMEDID:2824190
Martin, C; Paz-Ares, J. 1997. MYB transcription factors in plants. Trends Genet. 13(2):67-73 PUBMEDID:9055608