Plant Transcription factor database - Universität Potsdam
version: 3.0

Micromonas pusilla CCMP1545 MYB-related Family

Description

Martin & Paz-Ares. 1997: The cloning of the first transcription factor from plants, the C1 gene of maize, indicated that plants use transcription factors that are structurally related to those of animals in their control of gene expression, because C1 showed significant structural homology to the vertebrate cellular proto-oncogene c-MYB. Since 1987, the catalogue of MYB-related transcription factors has increased considerably in size due, primarily, to the ever-expanding number of MYB genes identified in higher plants (Arabidopsis thaliana is estimated to contain more than a hundred MYB genes). In vertebrates, the MYB-related proto-oncogenes comprise a small family with a central role in controlling cellular proliferation and commitment to development. However, while the functions of some plant MYB genes are relatively well understood they are, at present, quite distinct from their animal counterparts.

Members of this family
  SHOULD possess Myb_DNA-binding domain
  SHOULD NOT possess ARID G2-like Response_reg SNF2_N trihelix domains

Domain alignments

Benchmark against A. thaliana

The Sensitivity and Positive Predictive Value (PPV) were assessed for the families MYB and MYB-related jointly. The data reported by Yanhui et al. 2006 for A. thaliana were taken as gold standard.

The gold standard reported 198 members for this families, 184 of which are present in ArabTFDB, giving a PPV of 0.88. Fourteen additional members not present in ArabTFDB might be false negatives, giving a Sensitivity of 0.93.

This family is also present in:

References

There are 16 gene models in this family



Gene modelDescriptionDomains
19042 e_gw1.8.286.1 Myb_DNA-binding
20863 e_gw1.11.443.1 Myb_DNA-binding
21479 e_gw1.12.277.1 Myb_DNA-binding
35008 estExt_Genewise1Plus.C_90411 Myb_DNA-binding SWIRM ZZ
40875 fgenesh1_pg.C_scaffold_8000117 Myb_DNA-binding
41764 fgenesh1_pg.C_scaffold_10000277 Myb_DNA-binding
46527 estExt_fgenesh1_pg.C_20142 Mov34 Myb_DNA-binding
52654 EuGene.0000130211 Myb_DNA-binding
54299 EuGene.0000170145 HSA Myb_DNA-binding
56781 EuGene.0000030935 Myb_DNA-binding
58149 EuGene.0000050454 Myb_DNA-binding
58670 EuGene.0000060179 Myb_DNA-binding
60572 EuGene.0000090123 Myb_DNA-binding
9060 gw1.3.920.1 Myb_DNA-binding
9558 gw1.11.409.1 Myb_DNA-binding
9847 gw1.7.537.1 Myb_DNA-binding

General references

Jin, H; Martin, C. 1999. Multifunctionality and diversity within the plant MYB-gene family. Plant Mol. Biol. 41(5):577-85 PUBMEDID:10645718
Klempnauer, KH; Sippel, AE. 1987. The highly conserved amino-terminal region of the protein encoded by the v-myb oncogene functions as a DNA-binding domain. EMBO J. 6(9):2719-25 PUBMEDID:2824190
Martin, C; Paz-Ares, J. 1997. MYB transcription factors in plants. Trends Genet. 13(2):67-73 PUBMEDID:9055608