Plant Transcription factor database - Universität Potsdam
version: 3.0

Arabidopsis thaliana PBF-2-like Family


Desveaux et al. 2005: Members of the Whirly family of proteins are found throughout the plant kingdom and are predicted to share the ability to bind to single-stranded DNA. Arabidopsis and potato Whirly orthologs act as transcription factors that regulate defense gene expression; the Arabidopsis Whirly protein AtWhy1 contributes to both basal and specific defense responses. Analysis of the crystal structure of potato StWhy1 has provided insight into the DNA-binding mechanism of this family of proteins, their mode of action and possible autoregulation. There is evidence to suggest that Whirly proteins might play roles in processes other than defense responses and could function in the chloroplast as well as in the nucleus.

Members of this family
  SHOULD possess Whirly domain

Domain alignments

This family is also present in:


There are 4 gene models in this family

Gene modelDescriptionDomains
AT1G14410.1 ATWHY1/PTAC1 (A. THALIANA WHIRLY 1); DNA binding / telomeric DNA binding Whirly
AT1G71260.1 ATWHY2 (A. THALIANA WHIRLY 2); DNA binding Whirly
AT2G02740.1 ATWHY3/PTAC11 (A. THALIANA WHIRLY 3); DNA binding Whirly

General references

Desveaux, D; Allard, J; Brisson, N; Sygusch, J. 2002. A new family of plant transcription factors displays a novel ssDNA-binding surface. Nat. Struct. Biol. 9(7):512-7 PUBMEDID:12080340
Desveaux, D; Després, C; Joyeux, A; Subramaniam, R; Brisson, N. 2000. PBF-2 is a novel single-stranded DNA binding factor implicated in PR-10a gene activation in potato. Plant Cell 12(8):1477-89 PUBMEDID:10948264
Desveaux, D; Maréchal, A; Brisson, N. 2005. Whirly transcription factors: defense gene regulation and beyond. Trends Plant Sci. 10(2):95-102 PUBMEDID:15708347