Plant Transcription factor database - Universität Potsdam
version: 3.0

Micromonas sp. RCC299 PHD Family


Bienz. 2006: PHD proteins seem to be found universally in the nucleus, and their functions tend to lie in the control of chromatin or transcription. Increasing evidence indicates that PHD fingers bind to specific nuclear protein partners, for which they apparently use their loop 2 surface. Perhaps each PHD finger has its own cognate nuclear ligand, much like RING fingers have their cognate E2 ligases. No doubt the list of specific PHD finger ligands will grow, and the set of these ligands is likely to reveal whether PHD fingers have a common function in the nucleus.

Members of this family
  SHOULD possess PHD domain
  SHOULD NOT possess Alfin-like DDT Homeobox JmjC JmjN Myb_DNA-binding zf-CCCH domains

Domain alignments

This family is also present in:


There are 20 gene models in this family

Gene modelDescriptionDomains
100066 fgenesh2_pg.C_Chr_04000261 AT_hook PHD
113407 AZW_EuGene.0500010059 PHD zf-C3HC4
56635 EuGene.0300010063 PHD
56867 EuGene.0300010295 NIF PHD
57801 EuGene.0400010330 HMG_box PHD PWWP SET zf-CW
59034 EuGene.0600010036 PHD
59735 EuGene.0700010020 PHD
60550 EuGene.0800010118 Helicase_C PHD SNF2_N
61390 EuGene.0900010373 PHD
61711 EuGene.1000010048 PHD SET
62154 EuGene.1000010491 PHD zf-C3HC4
62221 EuGene.1100010007 Helicase_C PHD SNF2_N
62531 EuGene.1100010317 FYRN PHD
62585 EuGene.1100010371 PHD
63308 EuGene.1200010480 PHD zf-4CXXC_R1
64780 EuGene.1600010141 PHD zf-CW
64962 EuGene.1700010023 DNA_methylase PHD
74866 gw2.10.601.1 PHD
77910 e_gw2.01.792.1 BAH PHD
88660 e_gw2.15.45.1 AAA BAH PHD

General references

Bienz, M. 2006. The PHD finger, a nuclear protein-interaction domain. Trends Biochem. Sci. 31(1):35-40 PUBMEDID:16297627