Plant Transcription factor database - Universität Potsdam
version: 3.0

Chlamydomonas reinhardtii SET Family


Marmorstein. 2003: The methylation of lysine residues on histone tails is catalyzed by proteins containing a conserved SET domain. A recent flurry of structures of SET domain proteins has revealed a new protein fold and a scaffold for understanding catalysis and substrate binding by these enzymes. The prospect that histone methylation might form an epigenetic code and the implicated involvement of SET domain proteins in cancer assures that structure-function studies of these enzymes will continue until their detailed mechanism of action is determined.

Members of this family
  SHOULD possess SET domain
  SHOULD NOT possess CXC PHD zf-C2H2 domains

Domain alignments

This family is also present in:


There are 14 gene models in this family

Gene modelDescriptionDomains
115484 e_gwW.13.124.1 SET
142793 Chlre2_kg.scaffold_6000283 SET
145254 Chlre2_kg.scaffold_13000167 SET
153371 Chlre2_kg.scaffold_60000060 SET
153832 Chlre2_kg.scaffold_68000004 SET
154505 Chlre2_kg.scaffold_84000003 Rubis-subs-bind SET
169142 fgenesh2_pg.C_scaffold_9000281 SET
172711 fgenesh2_pg.C_scaffold_19000110 FYRC FYRN PWWP SET
195549 OVA_Chlre2_kg.scaffold_11000080 SET
291416 au.g9366_t1 SET
295365 au.g13064_t1 SET
296863 au.g14483_t1 SET
37866 estExt_fgenesh1_pg.C_70a0010 AT_hook SET
6823 fgenesh1_pg.C_scaffold_7000374 SET YDG_SRA

General references

Marmorstein, R. 2003. Structure of SET domain proteins: a new twist on histone methylation. Trends Biochem. Sci. 28(2):59-62 PUBMEDID:12575990