Plant Transcription factor database - Universität Potsdam
version: 3.0

Galdieria sulphuraria SET Family


Marmorstein. 2003: The methylation of lysine residues on histone tails is catalyzed by proteins containing a conserved SET domain. A recent flurry of structures of SET domain proteins has revealed a new protein fold and a scaffold for understanding catalysis and substrate binding by these enzymes. The prospect that histone methylation might form an epigenetic code and the implicated involvement of SET domain proteins in cancer assures that structure-function studies of these enzymes will continue until their detailed mechanism of action is determined.

Members of this family
  SHOULD possess SET domain
  SHOULD NOT possess CXC PHD zf-C2H2 domains

Domain alignments

This family is also present in:


There are 6 gene models in this family

Gene modelDescriptionDomains
Gs01040.1 gb|EDP01099.1|__protein N-methyltransferase [Chlamydomonas reinhardtii] Rubis-subs-bind SET
Gs06840.1 ref|XP_001493467.1|__PREDICTED: similar to Enhancer of zeste homolog 1 (ENX-2) [Equus caballus] SET
Gs28030.1 ref|XP_001650833.1|__mixed-lineage leukemia protein, mll [Aedes aegypti] gb|EAT43160.1| mixed-lineage leukemia protein, mll [Aedes aegypti] | Symbols: SDG29 | SDG29 (SET DOMAIN GROUP 29) C1_1 FYRC FYRN SET
Gs30950.1 ref|NP_001077836.1|__EFS (EARLY FLOWERING IN SHORT DAYS) [Arabidopsis thaliana] 4635|protein histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20specific, putative, expressed SET
Gs37520.1 ref|NP_113353.1|__putative ribulose-1,5-bisphosphate carboxylase/oxygenase small subunit N-methyltransferase I [Guillardia theta] gb|AAK39909.1|AF165818_117 putative ribulose-1,5-bisphosphate carboxylase/oxygenase small subunit N-methyltransferase I [Guil Rubis-subs-bind SET
Gs46350.1 emb|CAG07226.1|__unnamed protein product [Tetraodon nigroviridis] RRM_1 SET

General references

Marmorstein, R. 2003. Structure of SET domain proteins: a new twist on histone methylation. Trends Biochem. Sci. 28(2):59-62 PUBMEDID:12575990