Plant Transcription factor database - Universität Potsdam
version: 3.0

Micromonas sp. RCC299 SET Family


Marmorstein. 2003: The methylation of lysine residues on histone tails is catalyzed by proteins containing a conserved SET domain. A recent flurry of structures of SET domain proteins has revealed a new protein fold and a scaffold for understanding catalysis and substrate binding by these enzymes. The prospect that histone methylation might form an epigenetic code and the implicated involvement of SET domain proteins in cancer assures that structure-function studies of these enzymes will continue until their detailed mechanism of action is determined.

Members of this family
  SHOULD possess SET domain
  SHOULD NOT possess CXC PHD zf-C2H2 domains

Domain alignments

This family is also present in:


There are 16 gene models in this family

Gene modelDescriptionDomains
104541 fgenesh2_pg.C_Chr_16000071 SET
108948 est_cluster_kg.Chr_09__112__3199298:1 SET
58534 EuGene.0500010267 SET
58938 EuGene.0500010671 SET zf-CCHC zf-CW
59535 EuGene.0600010537 SET
59669 EuGene.0600010671 SET
60208 EuGene.0700010493 SET
61510 EuGene.0900010493 SET
63398 EuGene.1300010048 SET
63548 EuGene.1300010198 SET
63742 EuGene.1300010392 Rubis-subs-bind SET
63874 EuGene.1400010009 Rubis-subs-bind SET
64853 EuGene.1600010214 SET
73010 gw2.04.626.1 SET
83006 e_gw2.06.606.1 SET
97985 fgenesh2_pm.C_Chr_10000067 SET

General references

Marmorstein, R. 2003. Structure of SET domain proteins: a new twist on histone methylation. Trends Biochem. Sci. 28(2):59-62 PUBMEDID:12575990