Plant Transcription factor database - Universität Potsdam
version: 3.0

Ostreococcus lucimarinus SET Family


Marmorstein. 2003: The methylation of lysine residues on histone tails is catalyzed by proteins containing a conserved SET domain. A recent flurry of structures of SET domain proteins has revealed a new protein fold and a scaffold for understanding catalysis and substrate binding by these enzymes. The prospect that histone methylation might form an epigenetic code and the implicated involvement of SET domain proteins in cancer assures that structure-function studies of these enzymes will continue until their detailed mechanism of action is determined.

Members of this family
  SHOULD possess SET domain
  SHOULD NOT possess CXC PHD zf-C2H2 domains

Domain alignments

This family is also present in:


There are 16 gene models in this family

Gene modelDescriptionDomains
15488 fgenesh1_pg.C_Chr_5000240 SET
16466 fgenesh1_pg.C_Chr_8000153 SET
25709 estExt_fgenesh1_pg.C_Chr_170017 SET
27063 eugene.1300010085 SET
2778 gwEuk.9.155.1 SET
28212 eugene.1700010005 SET
32372 eugene.0600010431 SET
40473 e_gwEuk.15.92.1 Rubis-subs-bind SET
43434 e_gwEuk.20.132.1 Rubis-subs-bind SET
5434 gwEuk.16.149.1 SET
5572 gwEuk.13.266.1 SET
5592 gwEuk.21.173.1 SET
7951 gwEuk.20.352.1 SET
8226 gwEuk.3.635.1 SET
8235 gwEuk.8.456.1 SET
88595 ost_11_007_106 SET zf-CW

General references

Marmorstein, R. 2003. Structure of SET domain proteins: a new twist on histone methylation. Trends Biochem. Sci. 28(2):59-62 PUBMEDID:12575990