Plant Transcription factor database - Universität Potsdam
version: 3.0

Physcomitrella patens SET Family


Marmorstein. 2003: The methylation of lysine residues on histone tails is catalyzed by proteins containing a conserved SET domain. A recent flurry of structures of SET domain proteins has revealed a new protein fold and a scaffold for understanding catalysis and substrate binding by these enzymes. The prospect that histone methylation might form an epigenetic code and the implicated involvement of SET domain proteins in cancer assures that structure-function studies of these enzymes will continue until their detailed mechanism of action is determined.

Members of this family
  SHOULD possess SET domain
  SHOULD NOT possess CXC PHD zf-C2H2 domains

Domain alignments

This family is also present in:


There are 26 gene models in this family

Gene modelDescriptionDomains
112173 e_gw1.3.187.1 Pre-SET SET
115268 e_gw1.13.85.1 Rubis-subs-bind SET
117602 e_gw1.21.120.1 SET
118539 e_gw1.25.68.1 Pre-SET SET
123452 e_gw1.44.58.1 SET
133280 e_gw1.101.81.1 SET
136931 e_gw1.133.53.1 SET
141673 e_gw1.181.20.1 Rubis-subs-bind SET
156277 e_gw1.523.16.1 Rubis-subs-bind SET
159404 estExt_fgenesh1_pg.C_120156 Rubis-subs-bind SET
160039 estExt_fgenesh1_pg.C_170231 SET
168382 estExt_fgenesh1_pg.C_1740036 SET
168813 estExt_fgenesh1_pg.C_1900031 Pre-SET SET YDG_SRA
169005 estExt_fgenesh1_pg.C_1960038 SET
174853 estExt_gwp_gw1.C_90106 Pre-SET SET YDG_SRA
182780 estExt_gwp_gw1.C_590271 SET
209618 estExt_Genewise1.C_550091 Rubis-subs-bind SET
212943 estExt_Genewise1.C_840108 SET
216087 estExt_Genewise1.C_1230106 SET
227225 estExt_Genewise1.C_4030018 SET
227869 estExt_Genewise1.C_4560012 Pre-SET SET
229540 fgenesh2_pg.scaffold_76000060 SET
27014 gw1.24.91.1 SET
30594 gw1.469.4.1 Pre-SET SET YDG_SRA
3159 gw1.523.5.1 Pre-SET SET
33525 gw1.102.81.1 SET

General references

Marmorstein, R. 2003. Structure of SET domain proteins: a new twist on histone methylation. Trends Biochem. Sci. 28(2):59-62 PUBMEDID:12575990