Plant Transcription factor database - Universität Potsdam
version: 3.0

Cyanidioschyzon merolae SNF2 Family

Description

Eisen et al. 1995: The SNF2 family of proteins includes representatives from a variety of species with roles in cellular processes such as transcriptional regulation (e.g. MOT1, SNF2 and BRM), maintenance of chromosome stability during mitosis (e.g. lodestar) and various aspects of processing of DNA damage, including nucleotide excision repair (e.g. RAD16 and ERCC6), recombinational pathways (e.g. RAD54) and post-replication daughter strand gap repair (e.g. RAD5). This family also includes many proteins with no known function. To better characterize this family of proteins we have used molecular phylogenetic techniques to infer evolutionary relationships among the family members. We have divided the SNF2 family into multiple subfamilies, each of which represents what we propose to be a functionally and evolutionarily distinct group. We have then used the subfamily structure to predict the functions of some of the uncharacterized proteins in the SNF2 family. We discuss possible implications of this evolutionary analysis on the general properties and evolution of the SNF2 family.

Members of this family
  SHOULD possess SNF2_N domain
  SHOULD NOT possess AP2 PHD domains

Domain alignments

This family is also present in:

References

There are 13 gene models in this family



Gene modelDescriptionDomains
CMH195C chromatin remodeling complex SWI/SNF component, Snf2 Helicase_C SNF2_N
CMI119C similar to DNA repair protein rad16 Helicase_C SNF2_N
CMJ200C SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a Helicase_C SNF2_N
CML287C helicase-like protein Helicase_C SNF2_N zf-C3HC4
CMM245C similar to RING finger-like protein Helicase_C SNF2_N
CMM316C homeotic gene regulator BRAHMA HSA Helicase_C SNF2_N
CMO092C DNA repair and recombination protein RAD26 Helicase_C SNF2_N
CMQ215C chromodomain helicase DNA binding protein CHD Chromo FYRC FYRN Helicase_C ResIII SNF2_N
CMQ363C SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a HAND Helicase_C SLIDE SNF2_N
CMR070C SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like Helicase_C SNF2_N
CMR259C probable DNA repair protein RAD5 Helicase_C SNF2_N zf-C3HC4 zf-MIZ
CMS464C TBP-associated factor 172, similar to SWI2/SNF2 family Helicase_C SNF2_N
CMT353C unknown snf2 family helicase HSA Helicase_C SNF2_N

General references

Bork, P; Koonin, EV. 1993. An expanding family of helicases within the 'DEAD/H' superfamily. Nucleic Acids Res. 21(3):751-2 PUBMEDID:8382805
Eisen, JA; Sweder, KS; Hanawalt, PC. 1995. Evolution of the SNF2 family of proteins: subfamilies with distinct sequences and functions. Nucleic Acids Res. 23(14):2715-23 PUBMEDID:7651832