Plant Transcription factor database - Universität Potsdam
version: 3.0

Oryza sativa subsp. indica SWI/SNF-BAF60b Family


Kussie et al. 1996:The MDM2 oncoprotein is a cellular inhibitor of the p53 tumor suppressor in that it can bind the transactivation domain of p53 and downregulate its ability to activate transcription. In certain cancers, MDM2 amplification is a common event and contributes to the inactivation of p53. The crystal structure of the 109-residue amino-terminal domain of MDM2 bound to a 15-residue transactivation domain peptide of p53 revealed that MDM2 has a deep hydrophobic cleft on which the p53 peptide binds as an amphipathic alpha helix. The interface relies on the steric complementarity between the MDM2 cleft and the hydrophobic face of the p53 alpha helix and, in particular, on a triad of p53 amino acids-Phe19, Trp23, and Leu26-which insert deep into the MDM2 cleft. These same p53 residues are also involved in transactivation, supporting the hypothesis that MDM2 inactivates p53 by concealing its transactivation domain. The structure also suggests that the amphipathic alpha helix may be a common structural motif in the binding of a diverse family of transactivation factors to the TATA-binding protein-associated factors.

Members of this family
  SHOULD possess SWIB domain

Domain alignments

This family is also present in:


There are 10 gene models in this family

Gene modelDescriptionDomains
OsIBCD004093 Chr01_6297,2598,,,1,2598, GYF Plus-3 SWIB
OsIBCD004941 Chr02_306,396,,,1,396, SWIB
OsIBCD012058 Chr03_5480,435,,,1,435, SWIB
OsIBCD012074 Chr03_5501,1104,,,1,1104, DEK_C SWIB
OsIBCD014092 Chr04_2443,1389,,,1,1389, SWIB
OsIBCD015924 Chr04_5050,1170,,,1,1170, DEK_C SWIB
OsIBCD018046 Chr05_3250,2097,,,1,2097, GYF Plus-3 SWIB
OsIBCD027002 Chr08_3942,1203,,,1,1203, SWIB
OsIBCD027639 Chr09_339,309,,,1,309, SWIB
OsIBCD035092 Chr12_2301,435,,,1,435, SWIB

General references

Bennett-Lovsey, R; Hart, SE; Shirai, H; Mizuguchi, K. 2002. The SWIB and the MDM2 domains are homologous and share a common fold. Bioinformatics 18(4):626-30 PUBMEDID:12016060
Kussie, PH; Gorina, S; Marechal, V; Elenbaas, B; Moreau, J; Levine, AJ; Pavletich, NP. 1996. Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science 274(5289):948-53 PUBMEDID:8875929