Plant Transcription factor database - Universität Potsdam
version: 3.0

Oryza sativa subsp. japonica SWI/SNF-BAF60b Family

Description

Kussie et al. 1996:The MDM2 oncoprotein is a cellular inhibitor of the p53 tumor suppressor in that it can bind the transactivation domain of p53 and downregulate its ability to activate transcription. In certain cancers, MDM2 amplification is a common event and contributes to the inactivation of p53. The crystal structure of the 109-residue amino-terminal domain of MDM2 bound to a 15-residue transactivation domain peptide of p53 revealed that MDM2 has a deep hydrophobic cleft on which the p53 peptide binds as an amphipathic alpha helix. The interface relies on the steric complementarity between the MDM2 cleft and the hydrophobic face of the p53 alpha helix and, in particular, on a triad of p53 amino acids-Phe19, Trp23, and Leu26-which insert deep into the MDM2 cleft. These same p53 residues are also involved in transactivation, supporting the hypothesis that MDM2 inactivates p53 by concealing its transactivation domain. The structure also suggests that the amphipathic alpha helix may be a common structural motif in the binding of a diverse family of transactivation factors to the TATA-binding protein-associated factors.

Members of this family
  SHOULD possess SWIB domain

Domain alignments

This family is also present in:

References

There are 11 gene models in this family



Gene modelDescriptionDomains
LOC_Os01g66140.1 plus-3 domain containing protein, putative, expressed GYF Plus-3 SWIB
LOC_Os02g03730.1 SWIB/MDM2 domain containing protein, expressed SWIB
LOC_Os03g55310.1 SWIB/MDM2 domain containing protein, expressed SWIB
LOC_Os03g55570.1 upstream activation factor subunit spp27, putative, expressed DEK_C SWIB
LOC_Os04g31320.1 SWIB/MDM2 domain containing protein, expressed SWIB
LOC_Os04g56980.1 SWIB/MDM2 domain containing protein, expressed SWIB
LOC_Os05g34780.1 retrotransposon protein, putative, Ty3-gypsy subclass, expressed Plus-3 SWIB
LOC_Os08g39310.1 SWIB/MDM2 domain containing protein, expressed SWIB
LOC_Os09g04720.1 SWIB/MDM2 domain containing protein, expressed SWIB
LOC_Os10g36810.1 plus-3 domain containing protein, putative, expressed AT_hook GYF Plus-3 SWIB
LOC_Os12g32280.1 SWIB/MDM2 domain containing protein, expressed SWIB

General references

Bennett-Lovsey, R; Hart, SE; Shirai, H; Mizuguchi, K. 2002. The SWIB and the MDM2 domains are homologous and share a common fold. Bioinformatics 18(4):626-30 PUBMEDID:12016060
Kussie, PH; Gorina, S; Marechal, V; Elenbaas, B; Moreau, J; Levine, AJ; Pavletich, NP. 1996. Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science 274(5289):948-53 PUBMEDID:8875929