Plant Transcription factor database - Universität Potsdam
version: 3.0

Populus trichocarpa SWI/SNF-BAF60b Family

Description

Kussie et al. 1996:The MDM2 oncoprotein is a cellular inhibitor of the p53 tumor suppressor in that it can bind the transactivation domain of p53 and downregulate its ability to activate transcription. In certain cancers, MDM2 amplification is a common event and contributes to the inactivation of p53. The crystal structure of the 109-residue amino-terminal domain of MDM2 bound to a 15-residue transactivation domain peptide of p53 revealed that MDM2 has a deep hydrophobic cleft on which the p53 peptide binds as an amphipathic alpha helix. The interface relies on the steric complementarity between the MDM2 cleft and the hydrophobic face of the p53 alpha helix and, in particular, on a triad of p53 amino acids-Phe19, Trp23, and Leu26-which insert deep into the MDM2 cleft. These same p53 residues are also involved in transactivation, supporting the hypothesis that MDM2 inactivates p53 by concealing its transactivation domain. The structure also suggests that the amphipathic alpha helix may be a common structural motif in the binding of a diverse family of transactivation factors to the TATA-binding protein-associated factors.

Members of this family
  SHOULD possess SWIB domain

Domain alignments

This family is also present in:

References

There are 20 gene models in this family



Gene modelDescriptionDomains
175166 gw1.I.3766.1 Plus-3 SWIB
195668 gw1.IV.757.1 Plus-3 SWIB
199430 gw1.IV.4519.1 Plus-3 SWIB
201097 gw1.IX.1562.1 Plus-3 SWIB
201590 gw1.IX.2055.1 DEK_C SWIB
208461 gw1.V.3862.1 DEK_C SWIB
252646 gw1.XV.2082.1 SWIB
254792 gw1.XVI.731.1 DEK_C SWIB
424205 gw1.57.172.1 AT_hook GYF SWIB
549692 eugene3.00012133 SWIB
568469 eugene3.00110483 Plus-3 SWIB
575762 eugene3.00151157 SWIB
650754 grail3.0026015802 SWIB
722365 estExt_Genewise1_v1.C_LG_IX2461 SWIB
730132 estExt_Genewise1_v1.C_LG_XIII2348 SWIB
742845 estExt_Genewise1_v1.C_880282 SWIB
744224 estExt_Genewise1_v1.C_1300082 DEK_C SWIB
761789 fgenesh4_pg.C_LG_VI000099 DEK_C SWIB
806541 fgenesh4_pm.C_LG_XII000361 SWIB
813615 estExt_fgenesh4_kg.C_LG_I0088 SWIB

General references

Bennett-Lovsey, R; Hart, SE; Shirai, H; Mizuguchi, K. 2002. The SWIB and the MDM2 domains are homologous and share a common fold. Bioinformatics 18(4):626-30 PUBMEDID:12016060
Kussie, PH; Gorina, S; Marechal, V; Elenbaas, B; Moreau, J; Levine, AJ; Pavletich, NP. 1996. Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science 274(5289):948-53 PUBMEDID:8875929