Plant Transcription factor database - Universität Potsdam
version: 3.0

Vitis vinifera SWI/SNF-BAF60b Family

Description

Kussie et al. 1996:The MDM2 oncoprotein is a cellular inhibitor of the p53 tumor suppressor in that it can bind the transactivation domain of p53 and downregulate its ability to activate transcription. In certain cancers, MDM2 amplification is a common event and contributes to the inactivation of p53. The crystal structure of the 109-residue amino-terminal domain of MDM2 bound to a 15-residue transactivation domain peptide of p53 revealed that MDM2 has a deep hydrophobic cleft on which the p53 peptide binds as an amphipathic alpha helix. The interface relies on the steric complementarity between the MDM2 cleft and the hydrophobic face of the p53 alpha helix and, in particular, on a triad of p53 amino acids-Phe19, Trp23, and Leu26-which insert deep into the MDM2 cleft. These same p53 residues are also involved in transactivation, supporting the hypothesis that MDM2 inactivates p53 by concealing its transactivation domain. The structure also suggests that the amphipathic alpha helix may be a common structural motif in the binding of a diverse family of transactivation factors to the TATA-binding protein-associated factors.

Members of this family
  SHOULD possess SWIB domain

Domain alignments

This family is also present in:

References

There are 14 gene models in this family



Gene modelDescriptionDomains
GSVIVP00001170001 SWIB
GSVIVP00003621001 Plus-3 SWIB
GSVIVP00007730001 SWIB
GSVIVP00008087001 SWIB
GSVIVP00009707001 DEK_C SWIB
GSVIVP00010883001 DEK_C SWIB
GSVIVP00011106001 DEK_C SWIB
GSVIVP00017931001 SWIB
GSVIVP00022981001 SWIB
GSVIVP00035317001 SWIB
GSVIVP00035957001 GYF Plus-3 SWIB
GSVIVP00036530001 DEK_C SWIB
GSVIVP00036834001 Plus-3 SWIB
GSVIVP00037842001 SWIB

General references

Bennett-Lovsey, R; Hart, SE; Shirai, H; Mizuguchi, K. 2002. The SWIB and the MDM2 domains are homologous and share a common fold. Bioinformatics 18(4):626-30 PUBMEDID:12016060
Kussie, PH; Gorina, S; Marechal, V; Elenbaas, B; Moreau, J; Levine, AJ; Pavletich, NP. 1996. Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science 274(5289):948-53 PUBMEDID:8875929