Plant Transcription factor database - Universität Potsdam
version: 3.0

Zea mays SWI/SNF-BAF60b Family

Description

Kussie et al. 1996:The MDM2 oncoprotein is a cellular inhibitor of the p53 tumor suppressor in that it can bind the transactivation domain of p53 and downregulate its ability to activate transcription. In certain cancers, MDM2 amplification is a common event and contributes to the inactivation of p53. The crystal structure of the 109-residue amino-terminal domain of MDM2 bound to a 15-residue transactivation domain peptide of p53 revealed that MDM2 has a deep hydrophobic cleft on which the p53 peptide binds as an amphipathic alpha helix. The interface relies on the steric complementarity between the MDM2 cleft and the hydrophobic face of the p53 alpha helix and, in particular, on a triad of p53 amino acids-Phe19, Trp23, and Leu26-which insert deep into the MDM2 cleft. These same p53 residues are also involved in transactivation, supporting the hypothesis that MDM2 inactivates p53 by concealing its transactivation domain. The structure also suggests that the amphipathic alpha helix may be a common structural motif in the binding of a diverse family of transactivation factors to the TATA-binding protein-associated factors.

Members of this family
  SHOULD possess SWIB domain

Domain alignments

This family is also present in:

References

There are 39 gene models in this family



Gene modelDescriptionDomains
AC206780.3_FGP042 SWIB
GRMZM2G000298_P01 Plus-3 SWIB
GRMZM2G000298_P02 Plus-3 SWIB
GRMZM2G000298_P03 Plus-3 SWIB
GRMZM2G002160_P01 SWIB
GRMZM2G002845_P01 Plus-3 SWIB
GRMZM2G002845_P02 Plus-3 SWIB
GRMZM2G002845_P03 Plus-3 SWIB
GRMZM2G022382_P01 SWIB
GRMZM2G032631_P01 SWIB
GRMZM2G033091_P01 SWIB
GRMZM2G035325_P01 DEK_C SWIB
GRMZM2G046286_P01 SWIB
GRMZM2G049539_P01 GYF Plus-3 SWIB
GRMZM2G052416_P01 SWIB
GRMZM2G077088_P02 SWIB
GRMZM2G078379_P02 Plus-3 SWIB
GRMZM2G083880_P01 DEK_C SWIB
GRMZM2G083880_P02 DEK_C SWIB
GRMZM2G083880_P03 DEK_C SWIB
GRMZM2G084426_P01 SWIB
GRMZM2G084426_P02 SWIB
GRMZM2G084426_P03 SWIB
GRMZM2G092765_P01 AT_hook GYF Plus-3 SWIB
GRMZM2G106257_P01 Plus-3 SWIB
GRMZM2G107824_P01 Plus-3 SWIB
GRMZM2G107824_P02 Plus-3 SWIB
GRMZM2G107824_P03 Plus-3 SWIB
GRMZM2G124502_P01 DEK_C SWIB
GRMZM2G124502_P02 DEK_C SWIB
GRMZM2G124502_P03 DEK_C SWIB
GRMZM2G124620_P01 DEK_C SWIB
GRMZM2G143788_P01 SWIB
GRMZM2G148198_P01 SWIB
GRMZM2G164253_P01 SWIB
GRMZM2G167191_P01 SWIB
GRMZM2G168117_P01 SWIB
GRMZM2G171588_P01 DEK_C SWIB
GRMZM2G171588_P02 DEK_C SWIB

General references

Bennett-Lovsey, R; Hart, SE; Shirai, H; Mizuguchi, K. 2002. The SWIB and the MDM2 domains are homologous and share a common fold. Bioinformatics 18(4):626-30 PUBMEDID:12016060
Kussie, PH; Gorina, S; Marechal, V; Elenbaas, B; Moreau, J; Levine, AJ; Pavletich, NP. 1996. Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science 274(5289):948-53 PUBMEDID:8875929