Plant Transcription factor database - Universität Potsdam
version: 3.0

Arabidopsis lyrata TRAF Family


Stogios et al. 2005:The BTB domain (also known as the POZ domain) is a versatile protein-protein interaction motif that participates in a wide range of cellular functions, including transcriptional regulation, cytoskeleton dynamics, ion channel assembly and gating, and targeting proteins for ubiquitination. Several BTB domain structures have been experimentally determined, revealing a highly conserved core structure. The BTB domain is typically found as a single copy in proteins that contain only one or two other types of domain, and this defines the BTB-zinc finger (BTB-ZF), BTB-BACK-kelch (BBK), voltage-gated potassium channel T1 (T1-Kv), MATH-BTB, BTB-NPH3 and BTB-BACK-PHR (BBP) families of proteins, among others. BTB-ZF proteins are also known as the POK (POZ and Krüppel zinc finger) proteins. Many members of this large family have been characterized as important transcriptional factors, and several are implicated in development and cancer, most notably BCL6, leukemia/lymphoma related factor (LRF)/Pokemon, PLZF, hypermethylated in cancer (HIC)1 and Myc interacting zinc finger (MIZ)1.

Members of this family
  SHOULD possess BTB domain
  SHOULD NOT possess BACK MATH NPH3 zf-TAZ domains

Domain alignments

This family is also present in:


There are 31 gene models in this family

Gene modelDescriptionDomains
317462 fgenesh1_pm.C_scaffold_3000478 Arm BTB
323436 fgenesh1_pm.C_scaffold_5000980 BTB
324222 fgenesh1_pm.C_scaffold_5001766 Ank BTB
329065 fgenesh1_pm.C_scaffold_7001292 Ank BTB
331950 fgenesh1_pm.C_scaffold_8001293 BTB
345842 fgenesh1_pg.C_scaffold_4002184 BTB
348708 fgenesh1_pg.C_scaffold_5002100 BTB
357056 fgenesh1_pg.C_scaffold_8000843 BTB
474924 fgenesh2_kg.2__54__AT1G64280.1 Ank BTB
480104 fgenesh2_kg.3__2805__AT2G04740.1 BTB
483774 fgenesh2_kg.4__2834__AT2G46260.1 BTB
486647 fgenesh2_kg.5__2639__AT3G61600.1 BTB
488817 fgenesh2_kg.6__1951__AT5G19330.1 Arm BTB
489752 fgenesh2_kg.6__2886__AT4G08455.1 BTB
494469 fgenesh2_kg.8__285__AT5G45110.1 Ank BTB
858695 Al_scaffold_0007_2194 Ank BTB
874348 Al_scaffold_0003_2989 BTB
884714 Al_scaffold_0008_978 BTB
884836 Al_scaffold_0008_1100 BTB
887282 scaffold_100076.1 BTB
887760 scaffold_100554.1 BTB
889650 scaffold_102444.1 BTB
892582 scaffold_105376.1 BTB
901144 scaffold_400645.1 BTB
901145 scaffold_400646.1 BTB
901148 scaffold_400649.1 BTB
903336 scaffold_402837.1 BTB
903451 scaffold_402952.1 Ank BTB
909258 scaffold_601315.1 Arm BTB HEAT
912202 scaffold_604259.1 BTB
919604 scaffold_803004.1 BTB

General references

Deweindt, C; Albagli, O; Bernardin, F; Dhordain, P; Quief, S; Lantoine, D; Kerckaert, JP; Leprince, D. 1995. The LAZ3/BCL6 oncogene encodes a sequence-specific transcriptional inhibitor: a novel function for the BTB/POZ domain as an autonomous repressing domain. Cell Growth Differ. 6(12):1495-503 PUBMEDID:9019154
Stogios, PJ; Downs, GS; Jauhal, JJ; Nandra, SK; Privé, GG. 2005. Sequence and structural analysis of BTB domain proteins. Genome Biol. 6(10):R82 PUBMEDID:16207353