Plant Transcription factor database - Universität Potsdam
version: 3.0

Arabidopsis thaliana TRAF Family

Description

Stogios et al. 2005:The BTB domain (also known as the POZ domain) is a versatile protein-protein interaction motif that participates in a wide range of cellular functions, including transcriptional regulation, cytoskeleton dynamics, ion channel assembly and gating, and targeting proteins for ubiquitination. Several BTB domain structures have been experimentally determined, revealing a highly conserved core structure. The BTB domain is typically found as a single copy in proteins that contain only one or two other types of domain, and this defines the BTB-zinc finger (BTB-ZF), BTB-BACK-kelch (BBK), voltage-gated potassium channel T1 (T1-Kv), MATH-BTB, BTB-NPH3 and BTB-BACK-PHR (BBP) families of proteins, among others. BTB-ZF proteins are also known as the POK (POZ and Krüppel zinc finger) proteins. Many members of this large family have been characterized as important transcriptional factors, and several are implicated in development and cancer, most notably BCL6, leukemia/lymphoma related factor (LRF)/Pokemon, PLZF, hypermethylated in cancer (HIC)1 and Myc interacting zinc finger (MIZ)1.

Members of this family
  SHOULD possess BTB domain
  SHOULD NOT possess BACK MATH NPH3 zf-TAZ domains

Domain alignments

This family is also present in:

References

There are 29 gene models in this family



Gene modelDescriptionDomains
AT1G01640.1 speckle-type POZ protein-related BTB
AT1G01640.2 speckle-type POZ protein-related BTB
AT1G04390.1 binding / protein binding BTB
AT1G05690.1 BT3 (BTB and TAZ domain protein 3); protein binding / transcription regulator BTB
AT1G21780.1 BTB/POZ domain-containing protein BTB
AT1G21780.2 BTB/POZ domain-containing protein BTB
AT1G55760.1 BTB/POZ domain-containing protein BTB
AT1G64280.1 NPR1 (NONEXPRESSER OF PR GENES 1); protein binding Ank BTB
AT2G04740.1 ankyrin repeat family protein BTB
AT2G05330.1 speckle-type POZ protein-related BTB
AT2G40440.1 BTB/POZ domain-containing protein BTB
AT2G40450.1 speckle-type POZ protein-related BTB
AT2G41370.1 BOP2 (BLADE ON PETIOLE2); protein binding Ank BTB
AT2G46260.1 BTB/POZ domain-containing protein BTB
AT3G48360.1 BT2 (BTB AND TAZ DOMAIN PROTEIN 2); protein binding / transcription factor/ transcription regulator BTB
AT3G56230.1 speckle-type POZ protein-related BTB
AT3G57130.1 BOP1 (BLADE ON PETIOLE 1); protein binding Ank BTB
AT3G61600.1 ATPOB1 (Arabidopsis thaliana POZ/BTB containing-protein 1); protein binding BTB
AT3G61600.2 ATPOB1 (Arabidopsis thaliana POZ/BTB containing-protein 1); protein binding BTB
AT4G04090.1 speckle-type POZ protein-related BTB
AT4G08455.1 BTB/POZ domain-containing protein BTB
AT4G19660.1 NPR4 (NPR1-LIKE PROTEIN 4); protein binding Ank BTB
AT4G26120.1 ankyrin repeat family protein / BTB/POZ domain-containing protein Ank BTB
AT5G13060.1 armadillo/beta-catenin repeat family protein / BTB/POZ domain-containing protein Arm BTB HEAT
AT5G19330.1 armadillo/beta-catenin repeat family protein / BTB/POZ domain-containing protein Arm BTB HEAT
AT5G19330.2 armadillo/beta-catenin repeat family protein / BTB/POZ domain-containing protein Arm BTB HEAT
AT5G45110.1 NPR3 (NPR1-LIKE PROTEIN 3); protein binding Ank BTB
AT5G48510.1 speckle-type POZ protein-related BTB
AT5G63160.1 BT1 (BTB and TAZ domain protein 1); protein binding / transcription regulator BTB

General references

Deweindt, C; Albagli, O; Bernardin, F; Dhordain, P; Quief, S; Lantoine, D; Kerckaert, JP; Leprince, D. 1995. The LAZ3/BCL6 oncogene encodes a sequence-specific transcriptional inhibitor: a novel function for the BTB/POZ domain as an autonomous repressing domain. Cell Growth Differ. 6(12):1495-503 PUBMEDID:9019154
Stogios, PJ; Downs, GS; Jauhal, JJ; Nandra, SK; Privé, GG. 2005. Sequence and structural analysis of BTB domain proteins. Genome Biol. 6(10):R82 PUBMEDID:16207353