Arabidopsis thaliana TRAF Family

Description

Stogios et al. 2005:The BTB domain (also known as the POZ domain) is a versatile protein-protein interaction motif that participates in a wide range of cellular functions, including transcriptional regulation, cytoskeleton dynamics, ion channel assembly and gating, and targeting proteins for ubiquitination. Several BTB domain structures have been experimentally determined, revealing a highly conserved core structure. The BTB domain is typically found as a single copy in proteins that contain only one or two other types of domain, and this defines the BTB-zinc finger (BTB-ZF), BTB-BACK-kelch (BBK), voltage-gated potassium channel T1 (T1-Kv), MATH-BTB, BTB-NPH3 and BTB-BACK-PHR (BBP) families of proteins, among others. BTB-ZF proteins are also known as the POK (POZ and Krüppel zinc finger) proteins. Many members of this large family have been characterized as important transcriptional factors, and several are implicated in development and cancer, most notably BCL6, leukemia/lymphoma related factor (LRF)/Pokemon, PLZF, hypermethylated in cancer (HIC)1 and Myc interacting zinc finger (MIZ)1.

Domain alignments

This family is also present in:

• Cyanidioschyzon merolae
• Galdieria sulphuraria
• Micromonas pusilla CCMP1545
• Micromonas sp. RCC299
• Ostreococcus lucimarinus
• Ostreococcus tauri
• Chlamydomonas reinhardtii
• Chlorella sp. NC64A
• Coccomyxa sp. C-169
• Physcomitrella patens
• Selaginella moellendorffii
• Oryza sativa subsp. indica
• Oryza sativa subsp. japonica
• Sorghum bicolor
• Zea mays
• Arabidopsis lyrata
• Carica papaya
• Populus trichocarpa
• Vitis vinifera

References

There are 29 gene models in this family