Plant Transcription factor database - Universität Potsdam
version: 3.0

Carica papaya TRAF Family


Stogios et al. 2005:The BTB domain (also known as the POZ domain) is a versatile protein-protein interaction motif that participates in a wide range of cellular functions, including transcriptional regulation, cytoskeleton dynamics, ion channel assembly and gating, and targeting proteins for ubiquitination. Several BTB domain structures have been experimentally determined, revealing a highly conserved core structure. The BTB domain is typically found as a single copy in proteins that contain only one or two other types of domain, and this defines the BTB-zinc finger (BTB-ZF), BTB-BACK-kelch (BBK), voltage-gated potassium channel T1 (T1-Kv), MATH-BTB, BTB-NPH3 and BTB-BACK-PHR (BBP) families of proteins, among others. BTB-ZF proteins are also known as the POK (POZ and Krüppel zinc finger) proteins. Many members of this large family have been characterized as important transcriptional factors, and several are implicated in development and cancer, most notably BCL6, leukemia/lymphoma related factor (LRF)/Pokemon, PLZF, hypermethylated in cancer (HIC)1 and Myc interacting zinc finger (MIZ)1.

Members of this family
  SHOULD possess BTB domain
  SHOULD NOT possess BACK MATH NPH3 zf-TAZ domains

Domain alignments

This family is also present in:


There are 17 gene models in this family

Gene modelDescriptionDomains
evm.TU.supercontig_12.99 BTB
evm.TU.supercontig_122.16 BTB
evm.TU.supercontig_132.80 BTB
evm.TU.supercontig_135.43 Ank BTB
evm.TU.supercontig_147.26 Arm BTB HEAT
evm.TU.supercontig_184.4 BTB
evm.TU.supercontig_19.99 BTB
evm.TU.supercontig_26.190 BTB
evm.TU.supercontig_370.10 Arm BTB HEAT
evm.TU.supercontig_4.35 BTB
evm.TU.supercontig_418.2 BTB
evm.TU.supercontig_5.187 Ank BTB
evm.TU.supercontig_50.119 Ank BTB
evm.TU.supercontig_52.108 BTB TPR_1
evm.TU.supercontig_6.22 BTB
evm.TU.supercontig_61.2 Ank BTB
evm.TU.supercontig_64.150 BTB

General references

Deweindt, C; Albagli, O; Bernardin, F; Dhordain, P; Quief, S; Lantoine, D; Kerckaert, JP; Leprince, D. 1995. The LAZ3/BCL6 oncogene encodes a sequence-specific transcriptional inhibitor: a novel function for the BTB/POZ domain as an autonomous repressing domain. Cell Growth Differ. 6(12):1495-503 PUBMEDID:9019154
Stogios, PJ; Downs, GS; Jauhal, JJ; Nandra, SK; Privé, GG. 2005. Sequence and structural analysis of BTB domain proteins. Genome Biol. 6(10):R82 PUBMEDID:16207353