Plant Transcription factor database - Universität Potsdam
version: 3.0

Chlamydomonas reinhardtii TRAF Family


Stogios et al. 2005:The BTB domain (also known as the POZ domain) is a versatile protein-protein interaction motif that participates in a wide range of cellular functions, including transcriptional regulation, cytoskeleton dynamics, ion channel assembly and gating, and targeting proteins for ubiquitination. Several BTB domain structures have been experimentally determined, revealing a highly conserved core structure. The BTB domain is typically found as a single copy in proteins that contain only one or two other types of domain, and this defines the BTB-zinc finger (BTB-ZF), BTB-BACK-kelch (BBK), voltage-gated potassium channel T1 (T1-Kv), MATH-BTB, BTB-NPH3 and BTB-BACK-PHR (BBP) families of proteins, among others. BTB-ZF proteins are also known as the POK (POZ and Krüppel zinc finger) proteins. Many members of this large family have been characterized as important transcriptional factors, and several are implicated in development and cancer, most notably BCL6, leukemia/lymphoma related factor (LRF)/Pokemon, PLZF, hypermethylated in cancer (HIC)1 and Myc interacting zinc finger (MIZ)1.

Members of this family
  SHOULD possess BTB domain
  SHOULD NOT possess BACK MATH NPH3 zf-TAZ domains

Domain alignments

This family is also present in:


There are 32 gene models in this family

Gene modelDescriptionDomains
11662 fgenesh1_pg.C_scaffold_15000030 APH BTB DUF227 DnaJ Rieske
143897 Chlre2_kg.scaffold_9000128 BTB
145759 Chlre2_kg.scaffold_15000073 BTB
146398 Chlre2_kg.scaffold_1000222 BTB
146860 Chlre2_kg.scaffold_1000684 BTB
151030 Chlre2_kg.scaffold_35000026 BTB
151334 Chlre2_kg.scaffold_38000072 BTB
151740 Chlre2_kg.scaffold_40000023 BTB
151805 Chlre2_kg.scaffold_40000088 BTB
153097 Chlre2_kg.scaffold_53000029 BTB
166883 fgenesh2_pg.C_scaffold_5000352 BTB
186922 estExt_fgenesh2_pg.C_50340 BTB CorA
188181 estExt_fgenesh2_pg.C_90115 BTB Pericardin_rpt
193146 estExt_fgenesh2_pg.C_390041 BTB
193262 estExt_fgenesh2_pg.C_400060 BTB
193279 estExt_fgenesh2_pg.C_400082 BTB
286429 au.g4725_t1 BTB
293873 au.g11667_t1 BTB
325701 pg.chromosome_3_#_456 BTB DUF6
330520 pg.chromosome_12_#_674 BTB
379890 estExt_fgenesh1_pm.C_chromosome_110106 BTB
380951 estExt_fgenesh1_pm.C_chromosome_140009 BTB
394645 pasa_Sanger_mRNA12634 BTB
398123 pasa_Sanger_mRNA35916 BTB NHL
398723 pasa_Sanger_mRNA35580 Arm BTB HEAT
402799 pasa_Sanger_mRNA28300 BTB
410154 pasa_Sanger_mRNA16146 BTB
410155 pasa_Sanger_mRNA16147 BTB
413021 pasa_Sanger_mRNA11328 BTB
414959 pasa_Sanger_mRNA20445 BTB
422704 pasa_Sanger_mRNA24928 BTB
423158 pasa_Sanger_mRNA24494 BTB

General references

Deweindt, C; Albagli, O; Bernardin, F; Dhordain, P; Quief, S; Lantoine, D; Kerckaert, JP; Leprince, D. 1995. The LAZ3/BCL6 oncogene encodes a sequence-specific transcriptional inhibitor: a novel function for the BTB/POZ domain as an autonomous repressing domain. Cell Growth Differ. 6(12):1495-503 PUBMEDID:9019154
Stogios, PJ; Downs, GS; Jauhal, JJ; Nandra, SK; Privé, GG. 2005. Sequence and structural analysis of BTB domain proteins. Genome Biol. 6(10):R82 PUBMEDID:16207353