Plant Transcription factor database - Universität Potsdam
version: 3.0

Physcomitrella patens TRAF Family


Stogios et al. 2005:The BTB domain (also known as the POZ domain) is a versatile protein-protein interaction motif that participates in a wide range of cellular functions, including transcriptional regulation, cytoskeleton dynamics, ion channel assembly and gating, and targeting proteins for ubiquitination. Several BTB domain structures have been experimentally determined, revealing a highly conserved core structure. The BTB domain is typically found as a single copy in proteins that contain only one or two other types of domain, and this defines the BTB-zinc finger (BTB-ZF), BTB-BACK-kelch (BBK), voltage-gated potassium channel T1 (T1-Kv), MATH-BTB, BTB-NPH3 and BTB-BACK-PHR (BBP) families of proteins, among others. BTB-ZF proteins are also known as the POK (POZ and Krüppel zinc finger) proteins. Many members of this large family have been characterized as important transcriptional factors, and several are implicated in development and cancer, most notably BCL6, leukemia/lymphoma related factor (LRF)/Pokemon, PLZF, hypermethylated in cancer (HIC)1 and Myc interacting zinc finger (MIZ)1.

Members of this family
  SHOULD possess BTB domain
  SHOULD NOT possess BACK MATH NPH3 zf-TAZ domains

Domain alignments

This family is also present in:


There are 25 gene models in this family

Gene modelDescriptionDomains
106476 estExt_fgenesh1_pm.C_800024 Arm BTB HEAT
106616 estExt_fgenesh1_pm.C_870014 Arm BTB HEAT
118125 e_gw1.23.70.1 BTB
119190 e_gw1.28.113.1 Ank BTB
121620 e_gw1.36.87.1 Ank BTB
122867 e_gw1.42.45.1 BTB
130769 e_gw1.84.79.1 BTB
134565 e_gw1.113.91.1 BTB
165660 estExt_fgenesh1_pg.C_930047 BTB
170451 estExt_fgenesh1_pg.C_2450028 BTB
189922 estExt_gwp_gw1.C_1380126 BTB
219111 estExt_Genewise1.C_1690004 BTB
231552 fgenesh2_pg.scaffold_134000030 BTB
231894 fgenesh2_pg.scaffold_146000016 BTB
234547 estExt_fgenesh2_pg.C_1390052 Ank BTB
30287 gw1.375.34.1 BTB
31431 gw1.234.38.1 Ank BTB
3260 gw1.392.9.1 Ank BTB
61156 fgenesh1_pm.scaffold_326000002 BTB
66017 fgenesh1_pg.scaffold_9000054 BTB
67811 fgenesh1_pg.scaffold_16000042 BTB
77289 fgenesh1_pg.scaffold_64000041 BTB
93266 fgenesh1_pg.scaffold_240000003 BTB
93641 fgenesh1_pg.scaffold_245000068 BTB
97923 fgenesh1_pg.scaffold_338000010 BTB

General references

Deweindt, C; Albagli, O; Bernardin, F; Dhordain, P; Quief, S; Lantoine, D; Kerckaert, JP; Leprince, D. 1995. The LAZ3/BCL6 oncogene encodes a sequence-specific transcriptional inhibitor: a novel function for the BTB/POZ domain as an autonomous repressing domain. Cell Growth Differ. 6(12):1495-503 PUBMEDID:9019154
Stogios, PJ; Downs, GS; Jauhal, JJ; Nandra, SK; Privé, GG. 2005. Sequence and structural analysis of BTB domain proteins. Genome Biol. 6(10):R82 PUBMEDID:16207353