Plant Transcription factor database - Universität Potsdam
version: 3.0

Populus trichocarpa TRAF Family


Stogios et al. 2005:The BTB domain (also known as the POZ domain) is a versatile protein-protein interaction motif that participates in a wide range of cellular functions, including transcriptional regulation, cytoskeleton dynamics, ion channel assembly and gating, and targeting proteins for ubiquitination. Several BTB domain structures have been experimentally determined, revealing a highly conserved core structure. The BTB domain is typically found as a single copy in proteins that contain only one or two other types of domain, and this defines the BTB-zinc finger (BTB-ZF), BTB-BACK-kelch (BBK), voltage-gated potassium channel T1 (T1-Kv), MATH-BTB, BTB-NPH3 and BTB-BACK-PHR (BBP) families of proteins, among others. BTB-ZF proteins are also known as the POK (POZ and Krüppel zinc finger) proteins. Many members of this large family have been characterized as important transcriptional factors, and several are implicated in development and cancer, most notably BCL6, leukemia/lymphoma related factor (LRF)/Pokemon, PLZF, hypermethylated in cancer (HIC)1 and Myc interacting zinc finger (MIZ)1.

Members of this family
  SHOULD possess BTB domain
  SHOULD NOT possess BACK MATH NPH3 zf-TAZ domains

Domain alignments

This family is also present in:


There are 30 gene models in this family

Gene modelDescriptionDomains
171641 gw1.I.241.1 BTB
205341 gw1.V.742.1 Ank BTB
205458 gw1.V.859.1 Arm BTB HEAT
209056 gw1.V.4457.1 BTB
209921 gw1.V.5322.1 BTB
246937 gw1.XIV.3680.1 Ank BTB
253241 gw1.XV.2677.1 Ank BTB
277711 gw1.200.21.1 Ank BTB
409897 gw1.II.1232.1 BTB
419382 gw1.VIII.810.1 Arm BTB HEAT
424492 gw1.87.106.1 BTB
554445 eugene3.00031078 BTB
560428 eugene3.00060387 Ank BTB
566277 eugene3.00100835 Arm BTB HEAT
576209 eugene3.00160344 Ank BTB
646179 grail3.0089001301 BTB
657649 grail3.0009047601 BTB
708145 estExt_Genewise1_v1.C_LG_I6151 BTB
710754 estExt_Genewise1_v1.C_LG_II2256 Arm BTB HEAT
711056 estExt_Genewise1_v1.C_LG_II2822 Ank BTB
754573 fgenesh4_pg.C_LG_II000753 BTB
776193 fgenesh4_pg.C_LG_XV000621 BTB
801293 fgenesh4_pm.C_LG_V000385 BTB
818862 estExt_fgenesh4_pg.C_LG_V1641 BTB F5_F8_type_C
819262 estExt_fgenesh4_pg.C_LG_VI0944 Ank BTB
823396 estExt_fgenesh4_pg.C_LG_XII0887 BTB
826159 estExt_fgenesh4_pg.C_LG_XIX0452 BTB
829998 estExt_fgenesh4_pm.C_LG_II0046 BTB F5_F8_type_C
830168 estExt_fgenesh4_pm.C_LG_II0347 BTB
834770 estExt_fgenesh4_pm.C_LG_XIV0160 BTB

General references

Deweindt, C; Albagli, O; Bernardin, F; Dhordain, P; Quief, S; Lantoine, D; Kerckaert, JP; Leprince, D. 1995. The LAZ3/BCL6 oncogene encodes a sequence-specific transcriptional inhibitor: a novel function for the BTB/POZ domain as an autonomous repressing domain. Cell Growth Differ. 6(12):1495-503 PUBMEDID:9019154
Stogios, PJ; Downs, GS; Jauhal, JJ; Nandra, SK; Privé, GG. 2005. Sequence and structural analysis of BTB domain proteins. Genome Biol. 6(10):R82 PUBMEDID:16207353