Plant Transcription factor database - Universität Potsdam
version: 3.0

Sorghum bicolor TRAF Family

Description

Stogios et al. 2005:The BTB domain (also known as the POZ domain) is a versatile protein-protein interaction motif that participates in a wide range of cellular functions, including transcriptional regulation, cytoskeleton dynamics, ion channel assembly and gating, and targeting proteins for ubiquitination. Several BTB domain structures have been experimentally determined, revealing a highly conserved core structure. The BTB domain is typically found as a single copy in proteins that contain only one or two other types of domain, and this defines the BTB-zinc finger (BTB-ZF), BTB-BACK-kelch (BBK), voltage-gated potassium channel T1 (T1-Kv), MATH-BTB, BTB-NPH3 and BTB-BACK-PHR (BBP) families of proteins, among others. BTB-ZF proteins are also known as the POK (POZ and Krüppel zinc finger) proteins. Many members of this large family have been characterized as important transcriptional factors, and several are implicated in development and cancer, most notably BCL6, leukemia/lymphoma related factor (LRF)/Pokemon, PLZF, hypermethylated in cancer (HIC)1 and Myc interacting zinc finger (MIZ)1.

Members of this family
  SHOULD possess BTB domain
  SHOULD NOT possess BACK MATH NPH3 zf-TAZ domains

Domain alignments

This family is also present in:

References

There are 72 gene models in this family



Gene modelDescriptionDomains
4010765 gw1.7.2352.1 BTB
4060350 gw1.1.7203.1 BTB
4061091 gw1.1.7276.1 BTB
4061092 gw1.1.7277.1 BTB
4061869 gw1.1.7342.1 BTB
4100980 gw1.8.11877.1 BTB
4140881 gw1.10.15358.1 BTB
4150245 gw1.6.16826.1 BTB
4750807 estExt_Genewise1.C_chr_30626 Ank BTB
4770542 estExt_Genewise1.C_chr_102949 Ank BTB
4777048 e_gw1.1.7338.1 BTB
4782691 e_gw1.1.7341.1 BTB
4783661 e_gw1.1.17690.1 BTB
4787650 e_gw1.2.15670.1 BTB
4818891 e_gw1.5.16456.1 BTB
4822566 e_gw1.5.16577.1 BTB
4824022 e_gw1.5.16538.1 BTB
4828634 e_gw1.6.16850.1 BTB
4834942 e_gw1.7.1413.1 BTB
4838048 e_gw1.7.2310.1 BTB
4838135 e_gw1.7.2376.1 BTB
4840538 e_gw1.7.2304.1 BTB
4841213 e_gw1.7.2432.1 BTB
4845977 e_gw1.8.375.1 Ank BTB
4857294 e_gw1.10.15466.1 BTB
4859776 e_gw1.10.14926.1 BTB
4891836 estExt_Genewise1Plus.C_chr_77988 BTB
4896483 estExt_Genewise1Plus.C_chr_100584 BTB
4898217 estExt_Genewise1Plus.C_chr_107416 BTB
4968942 fgenesh1_pg.C_chr_2000258 BTB
4974503 fgenesh1_pg.C_chr_3001618 BTB
4982727 fgenesh1_pg.C_chr_5002087 BTB
4982735 fgenesh1_pg.C_chr_5002095 BTB
4982928 fgenesh1_pg.C_chr_5002288 BTB
4985591 fgenesh1_pg.C_chr_6002478 BTB
4986179 fgenesh1_pg.C_chr_7000269 BTB
4986689 fgenesh1_pg.C_chr_7000779 BTB
4986711 fgenesh1_pg.C_chr_7000801 BTB
4987949 fgenesh1_pg.C_chr_7002039 BTB
4987951 fgenesh1_pg.C_chr_7002041 BTB
4987952 fgenesh1_pg.C_chr_7002042 BTB
4987953 fgenesh1_pg.C_chr_7002043 BTB
4995124 fgenesh1_pg.C_chr_10002301 BTB
5003100 estExt_fgenesh1_pg.C_chr_33793 BTB
5003210 estExt_fgenesh1_pg.C_chr_33965 BTB
5005188 estExt_fgenesh1_pg.C_chr_50094 BTB
5007305 estExt_fgenesh1_pg.C_chr_70029 BTB
5007626 estExt_fgenesh1_pg.C_chr_70755 BTB
5007631 estExt_fgenesh1_pg.C_chr_70775 BTB
5007647 estExt_fgenesh1_pg.C_chr_70842 BTB
5028942 Sb01g018720 BTB
5029158 Sb01g021770 BTB
5032081 Sb10g026750 BTB
5032085 Sb10g026790 BTB
5032532 Sb02g002490 BTB
5032967 Sb02g007900 BTB
5033638 Sb02g022410 BTB
5038584 Sb04g024950 BTB
5040875 Sb05g024680 BTB
5042690 Sb06g031500 BTB
5042691 Sb06g031510 BTB
5043288 Sb07g006520 BTB
5043292 Sb07g006570 BTB
5044168 Sb07g027390 BTB
5044409 Sb08g001915 BTB
5045050 Sb08g015510 BTB
5056330 Sb05g002500 Ank BTB
5058561 Sb07g006460 BTB
5060460 Sb09g019610 Arm BTB HEAT
5061111 Sb10g000240 BTB F5_F8_type_C
5061748 Sb10g020060 BTB
5062075 Sb10g026770 BTB

General references

Deweindt, C; Albagli, O; Bernardin, F; Dhordain, P; Quief, S; Lantoine, D; Kerckaert, JP; Leprince, D. 1995. The LAZ3/BCL6 oncogene encodes a sequence-specific transcriptional inhibitor: a novel function for the BTB/POZ domain as an autonomous repressing domain. Cell Growth Differ. 6(12):1495-503 PUBMEDID:9019154
Stogios, PJ; Downs, GS; Jauhal, JJ; Nandra, SK; Privé, GG. 2005. Sequence and structural analysis of BTB domain proteins. Genome Biol. 6(10):R82 PUBMEDID:16207353